Nalorphine

A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.

Also Known As:

Lethidrone; Nalorphine Hydrobromide; Nalorphine Hydrochloride; Nalorphine, (14 alpha)-Isomer; Nalorphine, L-tartrate (1:1); Hydrobromide, Nalorphine; Hydrochloride, Nalorphine; Allylnormorphine; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(2-propenyl)-, (5alpha,6alpha)-

Networked: 110 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chepak, Andriy: 1 article (10/2014)
2.	Hanrahan, Michael T: 1 article (10/2014)
3.	Kurogi, Katsuhisa: 1 article (10/2014)
4.	Liu, Ming-Cheh: 1 article (10/2014)
5.	Liu, Ming-Yih: 1 article (10/2014)
6.	Sakakibara, Yoichi: 1 article (10/2014)
7.	Suiko, Masahito: 1 article (10/2014)
8.	Formanchuk, O K: 1 article (04/2004)
9.	Sherman, D M: 1 article (04/2004)
10.	Hofmeyr, M: 1 article (12/2001)

Related Diseases

1.	Morphine Dependence 09/01/1953 - "Effects of single doses of N-Allylnormorphine on hindlimb reflexes of chronic spinal dogs during cycles of morphine addiction." 01/01/1977 - "A randomized and blind experimental design was used to study the effects of naloxone and nalorphine on the development of morphine dependence in monkeys. " 01/01/1977 - "The effects of naloxone and nalorphine during the development of morphine dependence in rhesus monkeys." 01/01/1977 - "After morphine self-administration was eliminated, responding to escape from nalorphine was maintained in the postdependent monkeys, showing no difference from escape responding during morphine dependence. " 04/01/1975 - "The significant decrease of corticosteroids observed after repeated administration of morphine and the rise in adrenal corticosteroids found after the injection of nalorphine to the morphinized animals suggest that some kind of morphine dependence had been developed in the cats after repeated administration of the drug."
2.	Motion Sickness (Airsickness) 03/01/1988 - "Based on the knowledge of some neurohormonal and neurochemical mechanisms of VVS pathogenesis, a new drug prevention and therapy of seasickness was proposed, efficacy of opioid antagonists naloxone and nalorphine was shown."
3.	Respiratory Insufficiency (Respiratory Failure) 02/01/1964 - "A NEARLY FATAL CASE WITH COMA, CONVULSIONS, AND SEVERE RESPIRATORY DEPRESSION, SUCCESSFULLY TREATED WITH NALORPHINE." 07/01/1977 - "After the administration of nalorphine changes in psychical state and respiratory depression were observed in all subjects, whereas naloxone caused no changes even after very high doses. " 10/01/1975 - "Comparison of results and their statistical verification showed that nalorphine alone causes respiratory depression and carbon dioxide stimulation is, beside the weak initial action, almost ineffective. " 07/01/1955 - "Can nalorphine hydrochloride prevent respiratory depression and death from overdose of barbiturates?" 04/01/1980 - "When increments of 10 mg/70 kg were given hourly the dose-effect curve for respiratory depression by nalbuphine was flatter than that of morphine, and maximum respiratory depression occurred after 30 mg/70 kg. In a separate study of 10 subjects nalbuphine was administered in 10 mg/70 kg increments to a total dose of 60 mg/70 kg; doses in excess of 30 mg/70 kg failed to increase respiratory depression beyond that induced by morphine 20 mg/70 kg. A ceiling effect for respiratory depression previously known to exist only for nalorphine was thereby demonstrated to apply to nalbuphine. "
4.	Shock 06/01/1984 - "During the hypotensive phase of electronocuous shock in rabbits, injection of nalorphine to the hypothalamus provoked elevation in the blood pressure (BP), recovery of the evoked potential (EP) of the sensorimotor brain cortex in response to electrodermal stimulation (EDS) of the hind limb. " 06/01/1984 - "[Changes in the arterial pressure and evoked potential in the sensorimotor cortex induced by nalorphine injected in the hypothalamus during painful electric shock in rabbits]." 01/01/1980 - "Under all three schedules of shock increment nalorphine decreased median shock levels and increased rates of responding in the presence of shock and in the absence of shock (i.e., during time out). " 01/01/1980 - "The effects of nalorphine were examined under a shock titration procedure in which squirrel monkeys received shock during 15-s period. " 01/01/1980 - "Nalorphine's effect under several schedules of electric shock titration."
5.	Miosis 12/01/1977 - "In three of the individuals definite miosis antagonized by nalorphine was observed at 9.5 hr. The dose of codeine for the second group was 60 mg/hr for 11 hr. Mild but definite subjective effects were experienced by each of the participants in this group. " 12/01/1977 - "Miosis produced by codeine is not antagonized by nalorphine until large oral doses are administered for several days. " 08/01/1968 - "It is based on the ability of nalorphine to produce mydriasis in subjects who have recently taken morphine-like drugs and to produce miosis in others. " 06/01/1965 - "STUDIES ON ANTAGONISM OF MORPHINE MIOSIS BY NALORPHINE AS A DIAGNOSTIC TEST FOR NARCOTIC USAGE."

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Naloxone (Narcan)
3.	Narcotic Antagonists (Opioid Antagonists)
4.	Nalorphine
5.	Nalbuphine (Nubain)
6.	Narcotics (Narcotic Analgesics)
7.	Naltrexone (ReVia)
8.	Carbon Dioxide
9.	sigma Receptors (sigma Receptor)
10.	mu Opioid Receptors (mu Opioid Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Self Administration (Administration, Self)
3.	Intravenous Injections
4.	Analgesia
5.	Intravenous Administration