Nairobi Sheep Disease

An arbovirus infection of sheep and goats transmitted by ticks. It is characterized by high fever and hemorrhagic gastroenteritis.

Also Known As:

Disease, Nairobi Sheep; Sheep Disease, Nairobi

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Infections: 526564
- Virus Diseases: 41777
  - RNA Virus Infections: 303
    - Bunyaviridae Infections: 34
      - Nairobi Sheep Disease: 9
  - Arbovirus Infections: 98
    - Nairobi Sheep Disease: 9
- Vector Borne Diseases: 374
  - Tick-Borne Diseases: 496
    - Nairobi Sheep Disease: 9
  - Arbovirus Infections: 98
    - Nairobi Sheep Disease: 9
Animal Diseases: 416
- Sheep Diseases: 13
  - Nairobi Sheep Disease: 9

Related Diseases

1.	Neoplasms (Cancer)
2.	Infections

Experts

1.	Guzman, Hilda: 2 articles (10/2016 - 01/2016)
2.	Tesh, Robert B: 2 articles (10/2016 - 01/2016)
3.	Groschup, Martin H: 1 article (07/2021)
4.	Hartlaub, Julia: 1 article (07/2021)
5.	Keller, Markus: 1 article (07/2021)
6.	Bente, Dennis A: 1 article (10/2016)
7.	Bào, Yīmíng: 1 article (10/2016)
8.	Jahrling, Peter B: 1 article (10/2016)
9.	Kuhn, Jens H: 1 article (10/2016)
10.	Ladner, Jason T: 1 article (10/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nairobi Sheep Disease:

1.	VaccinesIBA 08/01/1977 - "The antibody responses to experimental Nairobi sheep disease vaccines have been assayed. " 08/01/1977 - "The antibody response in sheep vaccinated with experimental Nairobi sheep disease vaccines." 02/16/1974 - "A Nairobi sheep disease vaccine."
2.	RNA (Ribonucleic Acid)IBA 01/01/2016 - "Global phylogenetic analyses of proteins encoded in the L, M, and S RNA segments of these and 20 other available nairovirus genomes identified nine well-supported genogroups (Nairobi sheep disease, Thiafora, Sakhalin, Keterah, Qalyub, Kasokero, Dera Ghazi Khan, Hughes, and Tamdy). " 04/01/1990 - "Cloned cDNA derived from the small (S) and medium (M) genomic RNA segments of Dugbe (DUG) virus, isolate ArD44313, a member of the Nairobi sheep disease (NSD) serogroup of nairoviruses (family, Bunyaviridae) was used to prepare 32P-labelled DNA and RNA probes. "
3.	Proteins (Proteins, Gene)FDA Link 01/01/2016 - "Global phylogenetic analyses of proteins encoded in the L, M, and S RNA segments of these and 20 other available nairovirus genomes identified nine well-supported genogroups (Nairobi sheep disease, Thiafora, Sakhalin, Keterah, Qalyub, Kasokero, Dera Ghazi Khan, Hughes, and Tamdy). " 03/30/2004 - "The identification of an ovarian tumor (OTU)-like protease motif in the L protein amino termini of the nairoviruses Dugbe, CCHF, and Nairobi sheep disease (NSD) indicates these proteins are members of the recently described OTU-like protease family and suggests that these large proteins may be polyproteins that are autoproteolytically cleaved or involved in deubiquitination."
4.	PolyproteinsIBA 03/30/2004 - "The identification of an ovarian tumor (OTU)-like protease motif in the L protein amino termini of the nairoviruses Dugbe, CCHF, and Nairobi sheep disease (NSD) indicates these proteins are members of the recently described OTU-like protease family and suggests that these large proteins may be polyproteins that are autoproteolytically cleaved or involved in deubiquitination."
5.	Complementary DNA (cDNA)IBA 04/01/1990 - "Cloned cDNA derived from the small (S) and medium (M) genomic RNA segments of Dugbe (DUG) virus, isolate ArD44313, a member of the Nairobi sheep disease (NSD) serogroup of nairoviruses (family, Bunyaviridae) was used to prepare 32P-labelled DNA and RNA probes. "
6.	RNA ProbesIBA 04/01/1990 - "Cloned cDNA derived from the small (S) and medium (M) genomic RNA segments of Dugbe (DUG) virus, isolate ArD44313, a member of the Nairobi sheep disease (NSD) serogroup of nairoviruses (family, Bunyaviridae) was used to prepare 32P-labelled DNA and RNA probes. "
7.	Peptide Hydrolases (Proteases)FDA Link 03/30/2004 - "The identification of an ovarian tumor (OTU)-like protease motif in the L protein amino termini of the nairoviruses Dugbe, CCHF, and Nairobi sheep disease (NSD) indicates these proteins are members of the recently described OTU-like protease family and suggests that these large proteins may be polyproteins that are autoproteolytically cleaved or involved in deubiquitination."
8.	DNA (Deoxyribonucleic Acid)IBA 04/01/1990 - "Cloned cDNA derived from the small (S) and medium (M) genomic RNA segments of Dugbe (DUG) virus, isolate ArD44313, a member of the Nairobi sheep disease (NSD) serogroup of nairoviruses (family, Bunyaviridae) was used to prepare 32P-labelled DNA and RNA probes. "
9.	Butylated Hydroxyanisole (BHA)IBA 01/01/1980 - "8735 Amblyomma variegatum (Fabricius) were tested, 98.6% of which were taken from cattle, yielding 36 strains of Dugbe (DUG), four strains of Nairobi sheep disease (NSD), three strains of Bhanja (BHA), one strain of Thogoto (THO) and five strains of virus which could not be characterized. "
10.	AntigensIBA 06/01/1996 - "Cross-reactivity for the nairoviruses, Hazara, Nairobi sheep disease and Dugbe, was detected in serum samples from 3/72 human patients with confirmed CCHF infection, and serum from 1/162 other patients reacted monospecifically with Dugbe antigen. "