Nafoxidine

An estrogen antagonist that has been used in the treatment of breast cancer.

Also Known As:

Nafoxidine Hydrochloride; U-11,100A; U-11000A; Hydrochloride, Nafoxidine; U 11,100A; U 11000A; U11,100A; U11000A; Pyrrolidine, 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-

Networked: 62 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Nafoxidine: 62
      - desmethylnafoxidine aziridine: 1
      - U-22,410A

Experts

1.	Banni, Mohamed: 1 article (04/2020)
2.	Kessabi, Kaouthar: 1 article (04/2020)
3.	Lahmar, Samar: 1 article (04/2020)
4.	Messaoudi, Imed: 1 article (04/2020)
5.	Durmaz, Ramazan: 1 article (08/2004)
6.	Kabadere, Selda: 1 article (08/2004)
7.	Oztopçu, Pnar: 1 article (08/2004)
8.	Uyar, Ruhi: 1 article (08/2004)
9.	Yaz, Gökçen: 1 article (08/2004)
10.	Atlas, Lena: 1 article (01/2003)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/1978 - "Clinical trial of nafoxidine in advanced breast cancer." 11/01/1977 - "Clinical trial of nafoxidine in adrenalectomized patients with advanced breast cancer." 04/06/1974 - "The synthetic non-steroidal antioestrogen nafoxidine (U-11, 100A) was given by mouth to 52 women with locally advanced or metastatic breast cancer, in 85% of whom the disease had become resistant to, or relapsed after, previous endocrine treatment. " 04/06/1974 - "Antioestrogens in treatment of breast cancer: value of nafoxidine in 52 advanced cases." 08/01/1972 - "Clinical trial of nafoxidine, an oestrogen antagonist in advanced breast cancer."
2.	Neoplasms (Cancer) 12/01/1986 - "Nafoxidine prolonged the survival time of the rats injected with the tumor cells; complete regression of the tumor was observed when rats bearing a 3-day-old tumor were injected with this compound. " 09/01/1973 - "Growth-stimulating effect of Nafoxidine on rat mammary tumor after ovariectomy." 02/01/1981 - "Estrogenic effects of nafoxidine on ovarian-dependent and independent mammary tumor lines in the mouse." 10/01/1976 - "There is a strong correlation of response to nafoxidine with the presence of estrogen receptor in the tumor and also with the response to previous hormonal treatment. " 04/01/1976 - "Nafoxidine hydrochloride can provide additional palliation to patients who responded to previous endocrine ablation and had tumors containing an estrogen receptor. "
3.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/1979 - "Phase II study of nafoxidine in the therapy for advanced renal carcinoma." 07/01/1981 - "Treatment of renal carcinoma: a phase III randomized trial of oral medroxyprogesterone (Provera), hydroxyurea, and nafoxidine." 07/01/1981 - "Seventy patients with metastatic renal carcinoma were randomized to receive hydroxyurea, nafoxidine, or medroxyprogesterone (Provera) orally. " 01/01/1981 - "A review of the literature on antiestrogen therapy for this tumor reveals 148 published cases of hypernephroma treated with tamoxifen or nafoxidine. "
4.	Scoliosis 04/01/2020 - "This study was carried out to investigate the effects of exposure to estrogen antagonist nafoxidine hydrochloride (NH) and/or melatonin (Mlt) on certain bone metabolism parameters in killifish Aphanius fasciatus, a species suggested to be a suitable model for studying spinal deformities such as scoliosis. "
5.	Adenocarcinoma 06/01/1976 - " In a trial of nafoxidine in 20 patients with adenocarcinoma of the kidney, 2 complete and 1 partial regressions were observed. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Estradiol (Delestrogen)
3.	Tamoxifen
4.	Estrogen Receptor Modulators (Antiestrogen)
5.	Estrogen Receptors
6.	Progesterone Receptors (Progesterone Receptor)
7.	Hormones (Hormone)
8.	Ethinyl Estradiol (Estinyl)
9.	Medroxyprogesterone Acetate (Depo-Provera)
10.	Testosterone (Sustanon)

Related Therapies and Procedures

1.	Therapeutics
2.	Adrenalectomy
3.	Injections
4.	Ovariectomy (Oophorectomy)
5.	Intravenous Injections