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NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)

A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.
Also Known As:
Cytochrome P450 Reductase; Cytochrome P-450 Oxidase; Ferrihemoprotein P450 Reductase; NADPH Cytochrome P450 Oxidoreductase; NADPH Cytochrome P450 Reductase; NADPH-Cytochrome P450 Reductase; NADPH-P450 Reductase; Cytochrome P 450 Oxidase; Cytochrome P 450 Reductase; Ferrihemoprotein P 450 Reductase; NADPH Cytochrome P 450 Oxidoreductase; NADPH Cytochrome P 450 Reductase; NADPH Ferrihemoprotein Reductase; NADPH P450 Reductase; Oxidase, Cytochrome P-450; P-450 Oxidase, Cytochrome; P450 Reductase, Cytochrome; P450 Reductase, NADPH-Cytochrome; Reductase, Cytochrome P-450; Reductase, Cytochrome P450; Reductase, Ferrihemoprotein P-450; Reductase, Ferrihemoprotein P450; Reductase, NADPH-Cytochrome P450; Reductase, NADPH-Ferrihemoprotein; Reductase, NADPH-P450; Cytochrome P-450 Reductase; Ferrihemoprotein P-450 Reductase; NADPH Cytochrome P-450 Oxidoreductase; NADPH Cytochrome P-450 Reductase; NADPH Cytochrome c Reductase; NADPH:ferrihemoprotein oxidoreductase
Networked: 206 relevant articles (3 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ding, Xinxin: 9 articles (01/2021 - 03/2005)
2. Patterson, Adam V: 7 articles (10/2020 - 09/2003)
3. Panda, Satya P: 6 articles (01/2016 - 11/2006)
4. Zhang, Qing-Yu: 5 articles (01/2021 - 03/2005)
5. Wilson, William R: 5 articles (10/2020 - 06/2007)
6. Gu, Jun: 4 articles (01/2020 - 03/2005)
7. Kranendonk, Michel: 4 articles (01/2016 - 07/2008)
8. Masters, Bettie Sue: 4 articles (01/2016 - 11/2006)
9. Marohnic, Christopher C: 4 articles (04/2012 - 11/2006)
10. Ding, Liang: 3 articles (01/2021 - 07/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Necrosis
01/01/2022 - "We also demonstrated the efficacy of co-expressing a mutant Arabidopsis thaliana HMGR1 catalytic domain, additional NADPH-cytochrome P450 reductase (CPR) transferring electrons to heterologous CYPs, and application of ascorbic acid for preventing leaf necrosis after agroinfiltration, to improve product yield. "
01/01/1997 - "It has been found that liver ischemia and reperfusion result in extensive necrosis, enzymatic disturbances, particularly in acinar zone 3. Ischemia as well as reperfusion decrease the cytochrome P450 content of hepatocytic microsomes and the activity of NADPH-cytochrome P-450 reductase. "
05/01/1983 - "Rabbit acetylating ability was sixfold that of male Wistar rats, a species susceptible to hepatic cell necrosis, whereas hepatic cytochrome P-450 and NADPH-cytochrome c reductase were significantly lower than that observed in control or phenobarbital-induced rats. "
05/01/1987 - "Dose-related increases in organ (liver and kidney) weight/body weight ratios, individual cell necrosis in the liver, and hepatic microsomal NADPH cytochrome c reductase and peroxisomal palmitoyl-CoA oxidase and catalase activities were found in both the dosed-fed and gavage groups. "
04/01/1984 - "Parameters measured were (1) severity of hepatocellular necrosis as judged by light microscopy of liver sections, (2) activity of alanine aminotransferase and aspartate aminotransferase in serum, and (3) hepatic microsomal cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity. "
3. Sarcoma (Soft Tissue Sarcoma)
4. Hepatocellular Carcinoma (Hepatoma)
5. Liver Diseases (Liver Disease)

Related Drugs and Biologics

1. Cytochrome P-450 Enzyme System (Cytochrome P450)
2. Cytochromes b5 (Cytochrome b5)
3. NADP (NADPH)
4. Cytochrome-B(5) Reductase (Methemoglobin Reductase)
5. Prodrugs
6. Ascorbic Acid (Vitamin C)
7. Enzymes
8. NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
9. Xanthine Oxidase
10. Oxidoreductases (Dehydrogenase)

Related Therapies and Procedures

1. Cardiopulmonary Resuscitation (CPR)
2. Oral Administration
3. Therapeutics
4. Electrocoagulation (Electrocautery)