NADP Transhydrogenase (Transhydrogenase)

An enzyme present in the mitochondrial membrane of animals and in microorganisms. In the presence of energy (ATP) it catalyzes reversibly the reduction of NAD by NADPH to yield NADP and NADH. This reaction permits the utilization of the reducing properties of NADPH by the respiratory chain and in the reverse direction it allows the reduction of NADP for biosynthetic purposes. EC
Also Known As:
Transhydrogenase; Energy-Linked Transhydrogenase; Mitochondrial Transhydrogenase; NAD Transhydrogenase; NADPH NAD Transhydrogenase; NADPH Transferase; Nicotinamide Nucleotide Transhydrogenase; Energy Linked Transhydrogenase; NAD Transhydrogenase, NADPH; Nucleotide Transhydrogenase, Nicotinamide; Nucleotide Transhydrogenase, Pyridine; Transferase, NADPH; Transhydrogenase, Energy-Linked; Transhydrogenase, Mitochondrial; Transhydrogenase, NAD; Transhydrogenase, NADP; Transhydrogenase, NADPH NAD; Transhydrogenase, Nicotinamide Nucleotide; Transhydrogenase, Pyridine Nucleotide; Pyridine Nucleotide Transhydrogenase; NADPH:NAD+ oxidoreductase (B-specific)
Networked: 26 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results


1. Rydström, Jan: 2 articles (10/2011 - 07/2006)
2. Ashcroft, Frances M: 2 articles (08/2011 - 07/2006)
3. Cox, Roger D: 2 articles (08/2011 - 07/2006)
4. Kohlhaas, Michael: 1 article (09/2015)
5. Stadelmaier, Moritz: 1 article (09/2015)
6. Hohl, Mathias: 1 article (09/2015)
7. Duchen, Michael R: 1 article (09/2015)
8. Böhm, Michael: 1 article (09/2015)
9. Loewenthal, Neta: 1 article (09/2015)
10. Parvari, Ruti: 1 article (09/2015)

Related Diseases

1. Glucose Intolerance
2. Obesity
3. Neoplasms (Cancer)
04/30/1966 - "[Occurrence of pyridine nucleotide transhydrogenase in mitochondria of various ascites tumors]."
10/01/2011 - "Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H₂O₂--implications for their role in disease, especially cancer."
07/01/1965 - "II. Isocitrate dehydrogenase and transhydrogenase in tumor bearing rat liver and ascites tumor cells."
10/01/2011 - "We hypothesize that Complex I and the Δp-driven nicotinamide nucleotide transhydrogenase (Nnt) co-operate in an energy-dependent attenuation of the hydrogen-peroxide generation by Complex I. This co-operation is thought to be mediated by the NADPH/NADP⁺ ratio in the vicinity of the NADPH site of Complex I. It is proposed that the specific H₂O₂ production by Complex I, and the attenuation of it, is of importance for apoptosis, autophagy and the survival mechanism of a number of cancers. "
01/01/1971 - " The main topics of discussion are: 1) intracellular proteins binding sex hor mones and their metabolites (estrogen uptake by intact normal cells; upt ake of estrogens by mammary gland, and by mammary and other tumors; ster eospecific estrogen-binding proteids in responsive tissues; uptake of androgens by animal cells and formation of 5alpha-androstane and other derivatives; 5alpha-dihydrotestosterone-binding proteids; disposition of progesterone in various tissues); 2) testicular feminization syndrome; 3) effects of sex hormones on organ cultures, with comments on deoxyribonucleic acid synthesis and cell division in relation to tissue growth; 4) estrogen-mediated pyridine nucleotide transhydrogenase reactions; 5) intracellular "2nd messengers" and sex hormone action (polyamines); 6) physiological actions of 5beta-hydrogenated steroid metabolites and effects of sex hormones on erythropoiesis; 7) influences of sex hormones on structure, metabolism, and functions of reproductive organs (ribonucleic acid - RNA - and protein synthesis; RNA preparations and genital tissue growth; androgens and cation-activated adenosinetriphosphatase reactions; uptake of glucose and glycogen synthesis; mitochondrial reactions; gonadal hormones and sebaceous glands); and 8) medieval Chinese protoendocrinology."
4. Contagious Ecthyma (Orf)
5. Ascites

Related Drugs and Biologics

1. Insulin (Novolin)
4. Glucose (Dextrose)
5. pyridine
6. Cytochromes c (Cytochrome c)
7. Electron Transport Complex I (NADH-CoQ Reductase)
8. Gonadal Hormones
9. Oxaloacetate
10. Initiator Codon (Start Codon)