NADH Dehydrogenase

A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.

Also Known As:

Networked: 355 relevant articles (10 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yagi, Takao: 7 articles (01/2019 - 01/2006)
2.	Matsuno-Yagi, Akemi: 6 articles (03/2013 - 01/2006)
3.	Ishikawa, Mamoru: 5 articles (09/2018 - 03/2005)
4.	Kokaze, Akatsuki: 5 articles (09/2018 - 03/2005)
5.	Matsunaga, Naomi: 5 articles (09/2018 - 03/2005)
6.	Takashima, Yutaka: 5 articles (09/2018 - 03/2005)
7.	Yoshida, Masao: 5 articles (09/2018 - 03/2005)
8.	Seo, Byoung Boo: 5 articles (12/2009 - 01/2006)
9.	Marella, Mathieu: 4 articles (12/2009 - 01/2006)
10.	Fang, Hezhi: 3 articles (01/2022 - 04/2011)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 06/01/2001 - "Recently, the study of the NADH dehydrogenase complex has taken on new urgency as a result of reports that complex I defects are involved in many human mitochondrial diseases. " 09/01/2023 - "Zn caused oxidative damage and mitochondrial dysfunction, and impaired NADH dehydrogenase, thereby dysregulating the energy supply in brain. " 01/01/2023 - "Most chemicals present in our environment have been shown to target the mitochondria; remarkably, patients with PD show a mild deficiency in NADH dehydrogenase activity, signifying a possible link between PD and mitochondrial dysfunction. " 04/01/2020 - "To address the mitochondrial dysfunction mediated visual loss in EAE mice, self-complementary adeno-associated virus (scAAV) containing the NADH-dehydrogenase type-2 (NDI1) complex I gene was intravitreally injected into the mice after the onset of visual defects. " 07/01/2014 - "The obtained data allow understand the mechanism of mitochondrial diseases, involving damage of mitochondrial NADH-dehydrogenase, and may help in development of medicines for treatment of these diseases."
2.	Emphysema 10/27/2020 - "Correction to Supporting Information for Li et al., Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes." 11/07/2017 - "Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes."
3.	Breast Neoplasms (Breast Cancer) 10/01/2018 - "So, it can be concluded that the mitochondrial NADH dehydrogenase analysis may help to detect breast cancer in the early stages." 01/01/2022 - "One interaction between nuSNP rs17320521 in an intron of the WSC Domain Containing 2 (WSCD2) gene and mtSNP rs869096886, a synonymous variant mapped to the mitochondrially-encoded NADH dehydrogenase 4 (MT-ND4) gene, was confirmed in an independent breast cancer data set from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). " 05/01/2014 - "Mitochondrial NADH dehydrogenase polymorphisms are associated with breast cancer in Poland." 06/01/2010 - "Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland." 02/01/2010 - "Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor."
4.	Ischemia 08/01/2006 - "Prolonged ischemia-reperfusion produced a selective defect in complex I function distal to the NADH dehydrogenase component. " 01/01/1993 - "Furthermore, there is considerable evidence that the exogenous NADH-dehydrogenase of heart mitochondria is mainly responsible for functional changes of these organelles during ischemia/reperfusion." 12/01/1990 - "The results suggest that ischemia decreases the NADH-dehydrogenase activity of cardiac mitochondria." 01/01/1986 - "Our results, using autolysis in the rat heart as experimental model, indicate that the NADH dehydrogenase system was impaired relatively early during ischemia while transhydrogenation and NADPH dehydrogenation appeared to be relatively resistant." 11/01/2016 - "In this review, we summarize the proposed mechanisms of direct or indirect actions of anthocyanins within cardiac cells with the special emphasis on recently discovered their pharmacological effects on mitochondria in cardioprotection: reduction of cytosolic cytochrome c preventing apoptosis and sustainment of electron transfer between NADH dehydrogenase and cytochrome c supporting oxidative phosphorylation in ischemia-damaged mitochondria."
5.	Infections 06/01/2020 - "gigantica genotypes per infection and patterns of parasite spread, based on genetic characteristics of the mitochondrial NADH dehydrogenase 1 (mt-ND-1) locus. " 12/27/2019 - "Infection with Echinococcus granulosus (s.s.) in yaks and sheep was identified using NADH dehydrogenase subunit 1 and 5 (nad1 and nad5) mitochondrial genes while the genotype G6 of E. " 10/01/2023 - "A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing." 12/01/2023 - "multilocularis infection was confirmed by PCR addressing parts of the genes 12S rRNA and the NADH dehydrogenase subunit 2, showing very high identities with isolates from France, Slovakia and the USA." 10/01/2023 - "With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N-GQDs@Ru-NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds."

Related Drugs and Biologics

1.	Electron Transport Complex IV (Cytochrome c Oxidase)
2.	Succinate Dehydrogenase (Fumarate Reductase)
3.	NAD (NADH)
4.	Enzymes
5.	Particulate Matter
6.	Taurine
7.	Electron Transport Complex I (NADH-CoQ Reductase)
8.	Proteins (Proteins, Gene)
9.	RNA (Ribonucleic Acid)
10.	Succinic Acid (Succinate)

Related Therapies and Procedures

1.	Therapeutics
2.	Photothermal Therapy
3.	Transplantation
4.	Subcutaneous Injections
5.	Electrodes (Electrode)