Ipratropium (Ipratropium Bromide)

A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.

Also Known As:

Ipratropium Bromide; (endo,syn)-(+-)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane; Atrovent; Ipratropium Bromide Anhydrous; Ipratropium Bromide Monohydrate; Ipratropium Bromide, (endo,anti)-Isomer; Ipratropium Bromide, (exo,syn)-Isomer; Ipratropium Bromide, endo-Isomer; Itrop; Sch-1000; Sch-1178; N Isopropylatropine; Sch 1000; Sch 1178; Sch1000; Sch1178; N-Isopropylatropine; 8-Azoniabicyclo(3.2.1)octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, (endo,syn)-(+-)-

Networked: 1062 relevant articles (171 outcomes, 238 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Blanchette, Christopher M: 7 articles (12/2010 - 06/2007)
2.	Dalal, Anand A: 6 articles (06/2012 - 01/2009)
3.	Rutten-van Mölken, Maureen P M H: 5 articles (04/2012 - 01/2003)
4.	Stanford, Richard H: 5 articles (01/2009 - 03/2005)
5.	Donohue, James F: 4 articles (04/2016 - 01/2004)
6.	Maltais, François: 4 articles (01/2016 - 04/2007)
7.	Oostenbrink, Jan B: 4 articles (06/2007 - 01/2003)
8.	Barnes, Peter J: 4 articles (10/2005 - 09/2002)
9.	Rodrigo, Gustavo J: 4 articles (06/2003 - 06/2002)
10.	van Noord, J A: 4 articles (04/2002 - 04/2000)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2000 - "[Is nebulized ipratropium bromide effective in the treatment of exacerbations of chronic obstructive pulmonary disease?]." 05/01/1989 - "Inhaled ipratropium bromide (IPR) is effective in the management of COPD. " 11/14/1986 - "Single-agent studies have shown ipratropium to be both safe and effective in COPD. " 01/29/1996 - "These results show that ipratropium bromide, given by nebulization, is safe and effective in the outpatient treatment of COPD." 11/14/1986 - "Many studies have evaluated the efficacy of ipratropium bromide in chronic obstructive pulmonary disease (COPD). "
2.	Asthma (Bronchial Asthma) 07/01/1995 - "To determine whether inhaled ipratropium bromide provides an additive, clinically important improvement in children with acute asthma who are being treated with beta 2-agonists. " 06/01/2003 - "High and repetitive doses of ipratropium bromide in combination with beta(2)-agonists are indicated as first line treatment of severe acute asthma. " 06/01/2002 - "(2) The use of single-dose protocols of ipratropium bromide with beta(2)-agonist treatment produced, particularly in children with more severe acute asthma, a modest improvement in pulmonary function without reduction in hospital admissions; in adults, the data showed a similar increase in pulmonary function with an approximately 35% reduction in the hospital admission rate. " 01/01/1992 - "Therefore, ipratropium bromide offers bronchodilation and protection against a variety of stimuli and should more often be considered as an effective and safe drug for asthma treatment." 03/01/2020 - "Ipratropium bromide (IB), when administered with β2-agonists, is effective in reducing hospital admissions of children presenting to the emergency department (ED) with severe asthma. "
3.	Rhinorrhea 08/01/1992 - "Seventy percent of patients treated with 42 micrograms of ipratropium bromide thought it had good or excellent effect on rhinorrhea (p less than 0.05 vs placebo); significantly more patients thought that it had improved the quality of life (p = 0.02). " 05/01/1995 - "Treatment with the ipratropium spray resulted in a 30% reduction in rhinorrhea; this reduction was significantly greater than that seen with the saline vehicle. " 08/01/1999 - "Ipratropium bromide was safe and effective in controlling rhinorrhea and diminishing the interference by rhinorrhea in school attendance, concentration on school work, and sleep. " 05/01/1997 - "Treatment with ipratropium reduced symptoms of rhinorrhea primarily in patients with PNAR. " 08/01/1992 - "Mean duration and severity of rhinorrhea was decreased in both ipratropium bromide treatment groups by comparison with placebo, with consistently greatest improvement in the group treated with ipratropium bromide 42 micrograms per nostril three times a day. "
4.	Bronchiolitis 11/01/2023 - "Several drugs are in use for nebulization in children with acute bronchiolitis and no study has yet been conducted to compare the treatment outcome of nebulized ipratropium bromide and nebulized 3% hypertonic saline in Pakistan. " 11/01/2023 - "Comparison of nebulised 3% hypertonic saline with ipratropium bromide in treatment of children with bronchiolitis: a randomized control trial." 11/01/1983 - "In a double blind randomised trial, we found no evidence that nebulised ipratropium bromide was of clinical benefit in acute bronchiolitis." 11/01/2023 - "A total of one hundred (n=100) children of either sex diagnosed with acute bronchiolitis were enrolled and randomized either to be nebulized with 3% hypertonic saline or ipratropium bromide. " 11/01/2023 - "The objective was to compare the treatment outcome of nebulized hypertonic saline and ipratropium bromide in children with acute bronchiolitis. "
5.	Chronic Bronchitis 01/01/1998 - "The highest atrovent efficacy was recorded in patients with chronic bronchitis of smokers and chronic bronchitis in tracheobronchial diskinesia. " 05/01/1994 - "Whether nebulized ipratropium bromide is of benefit to mechanically ventilated patients with chronic bronchitis is not well defined. " 01/01/1985 - "We conclude that ipratropium bromide should be inhaled in high doses (0.2 mg) by hypersecretory patients with chronic bronchitis to improve mucociliary transport." 01/01/1985 - "Influence of 0.2 mg ipratropium bromide on mucociliary clearance in patients with chronic bronchitis." 03/26/1980 - "Ipratropium for chronic bronchitis."

Related Drugs and Biologics

1.	Albuterol (Salbutamol)
2.	Tiotropium Bromide (Spiriva)
3.	Bronchodilator Agents (Bronchodilators)
4.	Cholinergic Antagonists (Anticholinergics)
5.	Ipratropium (Ipratropium Bromide)
6.	Fenoterol
7.	Nasal Sprays
8.	Salmeterol Xinafoate (Serevent)
9.	Aerosols
10.	Formoterol Fumarate (Oxis)

Related Therapies and Procedures

1.	Therapeutics
2.	Nebulizers and Vaporizers (Inhaler)
3.	Metered Dose Inhalers (Metered Dose Inhaler)
4.	Length of Stay
5.	Noninvasive Ventilation