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Myotonic Dystrophy (Dystrophia Myotonica)

An autosomal dominant neuromuscular disorder which usually presents in early adulthood, characterized by progressive muscular atrophy (most frequently involving the hands, forearms, and face), myotonia, frontal baldness, lenticular opacities, and testicular atrophy. Cardiac conduction abnormalities, diaphragmatic weakness, and mild mental retardation may also occur. Congenital myotonic dystrophy is a severe form of this disorder, characterized by neonatal MUSCLE HYPOTONIA, feeding difficulties, respiratory muscle weakness, and an increased incidence of MENTAL RETARDATION. (From Adams et al., Principles of Neurology, 6th ed, pp1423-5; Joynt, Clinical Neurology, 1997, Ch16, pp16-7)
Also Known As:
Dystrophia Myotonica; Myotonia Atrophica; Myotonia Dystrophica; Steinert Disease; Congenital Myotonic Dystrophy; Steinert's Disease; Congenital Myotonic Dystrophies; Dystrophies, Congenital Myotonic; Dystrophies, Myotonic; Dystrophy, Congenital Myotonic; Dystrophy, Myotonic; Myotonic Dystrophies; Myotonic Dystrophies, Congenital; Myotonic Dystrophy, Congenital
Networked: 1654 relevant articles (27 outcomes, 131 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Myotonia
2. Insulin Resistance
3. Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
4. Muscular Dystrophies (Muscular Dystrophy)
5. Muscle Weakness

Experts

1. Thornton, Charles A: 37 articles (11/2015 - 07/2002)
2. Swanson, Maurice S: 21 articles (08/2015 - 08/2003)
3. Nakamori, Masayuki: 18 articles (12/2015 - 08/2005)
4. Cooper, Thomas A: 18 articles (06/2015 - 07/2002)
5. Gourdon, Geneviève: 18 articles (04/2015 - 01/2004)
6. Sobczak, Krzysztof: 16 articles (03/2015 - 01/2007)
7. Takahashi, Masanori P: 16 articles (03/2014 - 07/2002)
8. Meola, Giovanni: 15 articles (07/2015 - 10/2004)
9. Furling, Denis: 15 articles (01/2015 - 09/2002)
10. Disney, Matthew D: 13 articles (12/2015 - 05/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myotonic Dystrophy:
1. Glucose (Dextrose)FDA LinkGeneric
2. Insulin (Novolin)FDA Link
3. Phenytoin (Dilantin)FDA LinkGeneric
4. Selegiline (E250)FDA LinkGeneric
5. DNA (Deoxyribonucleic Acid)IBA
6. modafinil (armodafinil)FDA Link
7. CreatineIBA
8. HormonesIBA
9. CholesterolIBA
10. Carbamazepine (Tegretol)FDA LinkGeneric

Therapies and Procedures

1. Resistance Training
2. Epidural Anesthesia
3. Defibrillators (Defibrillator)
4. General Anesthesia
5. Therapeutics