Myoclonus (Nocturnal Myoclonus)

1305  relevant articles (107 outcomes, 84 trials/studies) found for this Disease

Nocturnal Myoclonus; Myoclonic Jerk; Myoclonus, Sleep; Myoclonic Jerking; Myoclonus Simplex; Myoclonus, Eyelid; Myoclonus, Intention; Myoclonus, Lower Extremity; Myoclonus, Oculopalatal; Myoclonus, Segmental; Myoclonus, Upper Extremity; Action Myoclonus; Extremity Myoclonus, Lower; Extremity Myoclonus, Upper; Eyelid Myoclonus; Intention Myoclonus; Jerk, Myoclonic; Jerking, Myoclonic; Jerks, Myoclonic; Lower Extremity Myoclonus; Myoclonic Jerks; Oculopalatal Myoclonus; Palatal Myoclonus; Segmental Myoclonus; Simplex, Myoclonus; Sleep Myoclonus; Upper Extremity Myoclonus; Myoclonus, Action; Myoclonus, Nocturnal; Myoclonus, Palatal; Polymyoclonus

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seizures (Seizure)
2.	Myoclonus (Nocturnal Myoclonus)
3.	Ataxia (Dyssynergia)
4.	Dystonia (Limb Dystonia)
5.	Ocular Motility Disorders (Convergence Insufficiency)

Experts

1.	Striano, Pasquale: 3 articles (08/2007 - 12/2005)
2.	Striano, Salvatore: 3 articles (08/2007 - 12/2005)
3.	Gasser, Thomas: 3 articles (11/2005 - 10/2002)
4.	Asmus, Friedrich: 3 articles (11/2005 - 10/2002)
5.	Genton, P: 3 articles (09/2005 - 09/2001)
6.	Gelisse, P: 3 articles (09/2005 - 09/2001)
7.	Hennessy, M J: 2 articles (05/2008 - 04/2001)
8.	Hjermind, L E: 2 articles (05/2008 - 05/2003)
9.	Asmus, F: 2 articles (05/2008 - 09/2001)
10.	Kock, Norman: 2 articles (03/2008 - 12/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myoclonus:

1.	Clonazepam (Rivotril)FDA LinkGeneric 06/01/2007 - "Subsequent therapy with low-dose clonazepam was highly effective in reducing myoclonic jerks and exaggerated startle reaction, and unlike previously used drugs, it was decisive in reducing hypertonia." 01/01/1986 - "Clonazepam improved myoclonus in 10 of 13 patients, two of whom had complete resolution of symptoms" 03/01/1977 - "Clonazepam is very effective in controlling the myoclonus" 09/01/2004 - "Oral administration of clonazepam was transiently effective for myoclonus" 02/01/1988 - "Clonazepam was effective in controlling the myoclonic jerks, which were a feature in this patient, without producing excessive sedation" Order ALL the reference details at left...
2.	Piracetam (Nootropil)IBA 01/01/2006 - "He presented with severe myoclonus, which was resistant to conventional therapy and dramatically improved after administration of 12-18 gm/die piracetam" 10/01/2000 - "In the placebo-controlled double-blind crossover trial of piracetam conducted in the UK, there was a significant improvement in cortical myoclonus" 10/01/2000 - "These results show that piracetam has a beneficial use in clinics for severe myoclonus patients when it is combined with anti-epileptic drugs, demonstrating an improvement in the myoclonus and QOL of patients." 07/01/1996 - "Treatment with piracetam in 5 patients significantly improved myoclonus" 05/01/2001 - "CONCLUSIONS: Piracetam given as add-on therapy seems to be an effective, sustained, and well-tolerated treatment of myoclonus" Order ALL the reference details at left...
3.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 08/01/1988 - "Of all the drugs which are usually thought to be effective in the treatment of myoclonus, only valproic acid brought some relief" 04/01/2003 - "However, after the administration of valproate, his cortical myoclonus improved, and the transient akinetorigid state also disappeared simultaneously" 08/10/1978 - "Post-anoxic action myoclonus: improvement with valproic acid." 06/01/1999 - "Inclusion criteria in the study were: a) myoclonic jerks, preferably on awakening; b) beginning of the symptoms between 8 and 26 year-of-age; c) typical pattern of electroencephalographic discharges; and d) good response to sodium valproate (VPA)" 01/01/2006 - "Action myoclonus responded appropriately to sodium valproate" Order ALL the reference details at left...
4.	etiracetam (levetiracetam)FDA Link 03/01/2002 - "Add-on therapy with levetiracetam significantly improved the patient's clinical condition, suppressed cortical myoclonus-associated spikes, and enabled further neurorehabilitation." 06/01/2004 - "PURPOSE: Disabling myoclonus is the main symptom in long-standing Unverricht-Lundborg disease (ULD), and levetiracetam (LEV) appears to be an effective anticonvulsant with promising short-term antimyoclonic properties" 05/01/2003 - "Case reports provide additional information regarding the potential efficacy of levetiracetam in postanoxic, post-encephalitic and progressive myoclonus" 04/01/2003 - "Levetiracetam is a new antiepileptic drug with a broad-spectrum activity that includes efficacy against positive myoclonus" 03/01/2005 - "Limited efficacy of levetiracetam on myoclonus of different etiologies." Order ALL the reference details at left...
5.	BenzodiazepinesIBA 07/01/1990 - "Benzodiazepines (BDZs) are often helpful in the treatment of myoclonus" 01/01/1986 - "Stimulus-sensitive myoclonus of the baboon Papio papio: pharmacological studies reveal interactions between benzodiazepines and the central cholinergic system." 02/15/2002 - "The myoclonus slightly regressed following treatment with benzodiazepines" 08/01/1991 - "In Papio papio baboons benzodiazepines can facilitate the appearance of a naturally occurring non-epileptic myoclonus, suggesting a possible role of GABAergic transmission in their physiopathology" 10/01/1987 - "Type B myoclonus in Papio papio: results of the central anticholinergic effect of benzodiazepines]" Order ALL the reference details at left...
6.	Carbidopa (Lodosyn)FDA LinkGeneric 12/01/1982 - "This rank order of potency differed from that observed for the order of potency of these drugs in inhibiting the myoclonus induced by L-5-hydroxytryptophan (5HTP) plus carbidopa in guinea-pigs (Luscombe, Jenner and Marsden, Neuropharmacology, 1981), perhaps indicating involvement of pharmacologically distinct indoleamine receptors" 06/01/1980 - "Six patients with myoclonus of varying cause were treated with L-5-hydroxytryptophan (L-5-HTP) and carbidopa" 06/01/1980 - "Treatment of myoclonus with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemical observations." 01/01/1976 - "Clinical and metabolic observations on the treatment of myoclonus with L-5-HTP and carbidopa." 02/01/1975 - "Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486." Order ALL the reference details at left...
7.	Diazepam (Valium)FDA LinkGeneric 10/01/1999 - "After diazepam treatment, stiffness and reflex myoclonus of lower extremities were disappeared and head retraction like reflex myoclonus was improved but remained" 08/01/2005 - "The EEG of control mice remained unaffected under all conditions, but the EEG of beta3 (-/-) injected with diazepam in week 1 was worsened, showing increased oscillatory activity at 5-6Hz, and more myoclonic jerks, particularly among males" 10/01/1993 - "Our patient developed encephalopathy, upper extremity myoclonus, and a periodic, triphasic electroencephalogic pattern that resolved acutely with intravenous diazepam treatment" 05/01/1977 - "Intravenously administered diazepam was useful in controlling the myoclonus to permit a renal biopsy" 09/01/1968 - "Action of diazepam on continuous myoclonus]" Order ALL the reference details at left...
8.	5-Hydroxytryptophan (5 Hydroxytryptophan)IBA 12/29/1995 - "Our data therefore confirm previous reports concerning the effects of 5-HT2A/2C receptor blockade on 5-HTP induced myoclonic jerks and suggest that both 5-HT1D and 5-HT1A receptors play an important role in mediating this behavioural response." 12/29/1995 - "Systemic administration of 5-hydroxytryptophan (5-HTP) to guinea pigs causes species-specific, rhythmic, whole body jerks (myoclonic jerks), the frequency and amplitude of which were measured in an automated apparatus" 12/29/1995 - "The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs." 07/01/1990 - "Further experience showed that only a few patients with myoclonus benefit from 5-HTP therapy" 11/10/1987 - "These data suggest that the functional integrity of serotonergic neurons is not requisite for the expression of myoclonus induced by 5-HTP in the guinea pig" Order ALL the reference details at left...
9.	Levodopa (L Dopa)FDA LinkGeneric 05/01/1975 - "Levodopa-induced myoclonus." 08/24/1974 - "Letter: Levodopa in treatment of myoclonus." 05/01/1998 - "Cortical myoclonus in levodopa-responsive parkinsonism." 02/01/1997 - "The occurrence of any one of four clinical features (myoclonus, absence of rest tremor, no response to levodopa, or no perceived need to treat with levodopa) was 10 times more likely in DLBD than PD (odds ratio = 10.29, 95% confidence interval = 2.58-41.11)" 07/01/1996 - "We describe a patient with parkinsonism unresponsive to levodopa who had myoclonus that was both spontaneous and induced by somatosensory stimuli" Order ALL the reference details at left...
10.	Serotonin (5 Hydroxytryptamine)IBA 01/01/2002 - "The rat model of posthypoxic myoclonus does not demonstrate a significant reduction in serotonin in any location of its brain and is generated by a non-oscillating circuit in the medulla" 01/01/1999 - "METHODS: The authors performed a pharmacologic study to identify specific serotonin receptor subtype antagonists effective in inhibiting myoclonus in posthypoxic rats" 01/01/1999 - "OBJECTIVE: To study specific serotonin (5-hydroxytryptamine [5-HT]) receptor subtype antagonists in an animal model of posthypoxic myoclonus" 11/20/1998 - "The present study examined the role of 5-hydroxytryptamine 5-HT receptor subtypes on 5-hydroxytryptamine- (5-HT-) mediated myoclonus in guinea pigs, evaluating head and whole-body jerking as two distinct behavioural responses" 01/01/2002 - "David Marsden in a discussion of the histologic findings of three of his human cases of posthypoxic myoclonus (page 117 of reference 10) and led him to question the hypothesis that posthypoxic myoclonus was due to a loss of serotonin neurons" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/1990 - "Not until patients with myoclonus and major functional disability were reported in the 1960s was attention given to understanding its basis and pharmacotherapy" 12/01/1989 - "A 24-yr-old woman suffering from traumatic spinal myoclonus which occurred after a diving injury, and which had not responded to pharmacotherapy, apparently resolved after treatment by manipulation of the spine" 07/15/2007 - "Chemotherapy and lung lobectomy resulted in complete tumor remission and disappearance of myoclonus" 03/01/1994 - "We suggest that the onset of one movement disorder after drug therapy (eg, myoclonus) may predict the development of other movement disorders (e.g., catatonia)" 10/15/1992 - "We report a case of dementia, myoclonus, peripheral neuropathy, and lipid storage in the skin due to antidepressant drug therapy, in which the discontinuation of drugs resulted in an improvement of clinical and electrophysiologic signs together with reduction of morphological evidence of lipid lysosomal storage." Order ALL the reference details at left...
2.	Anesthesia 02/04/1982 - "Choralose, a widely used anesthetic in neurophysiology, produces a unique pattern of anesthesia characterized by both an excitant (myoclonic jerks and startle response) and depressant (sedation and anesthesia) action" 07/01/1953 - "Influence of anesthesia on cortical irradiation and reflex myoclonus." 06/01/1999 - "She immediately felt a lancinating pain in her left limb during anesthesia at the level of L 4/5 and soon developed myoclonus in her left thigh" 06/01/1995 - "MEASUREMENTS AND MAIN RESULTS: There were 279 anesthesia-related occurrences, comprised almost entirely of five specific events: vomiting, hypoxemia (SpO2 less than 94%), tachycardia, agitation, and myoclonus" 10/01/2006 - "CONCLUSION: Pretreatment with etomidate (0.03 mg/kg), given 60 seconds before induction of anesthesia, is effective at reducing etomidate-induced myoclonus, without related side-effect." Order ALL the reference details at left...
3.	Cardiopulmonary Resuscitation (CPR) 12/01/2006 - "Besides established clinical and laboratory parameters, postanoxic myoclonus and NSE, serial TCD examinations following CPR may be helpful to predict the clinical outcome, but further studies with a larger number of patients are necessary to approve this hypothesis." 01/01/2005 - "RESULTS: Generalized myoclonus occurred within 24 hours after CPR" 01/01/2005 - "BACKGROUND: There is only limited data on improvements of critical medical care is resulting in a better outcome of comatose survivors of cardiopulmonary resuscitation (CPR) with generalized myoclonus" 01/01/2005 - "METHODS: Serial EEG examinations were done in 50 comatose survivors of CPR with generalized myoclonus seen over an 8 years period" 01/01/2005 - "Observations on comatose survivors of cardiopulmonary resuscitation with generalized myoclonus." Order ALL the reference details at left...
4.	Resuscitation 01/01/1979 - "Action myoclonus secondary to posthypoxic encephalopathy is being seen increasingly with improved resuscitation techniques" 10/01/1987 - "Incidence of postanoxic myoclonus after resuscitation for cardiorespiratory arrest]" 03/06/1995 - "Male Sprague-Dawley rats underwent experimentally induced cardiac arrest and resuscitation, subsequently exhibiting involuntary jerking movements (myoclonus) with salient features similar to the human form of the disorder" 01/01/1996 - "Male Sprague-Dawley rats developed posthypoxic myoclonus following 10-min cardiac arrest and resuscitation" 01/01/1996 - "Male Sprague-Dawley rats developed posthypoxic myoclonus following 10-min cardiac arrest and resuscitation" Order ALL the reference details at left...
5.	Activities of Daily Living (ADL) 08/01/1981 - "During six weeks of the trial an improvement in activities of daily living and a decrease of action myoclonus was noted in the PME patients" 02/24/2004 - "Myoclonus was evaluated semiquantitatively (territory, intensity, daily living activities)" 04/01/2004 - "The early onset of parkinsonism and myoclonus predict a rapidly evolving cognitive impairment and a more severe rate of progression with psychiatric disorders and dependency in activities of daily living" 07/01/2004 - "PARTICIPANTS: Three subjects whose activities of daily living were impaired due to intention myoclonus related to mitochondrial encephalomyopathy, stroke, and multiple sclerosis (MS)" Order ALL the reference details at left...