Peroxidase (Myeloperoxidase)

A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.

Also Known As:

Networked: 12896 relevant articles (398 outcomes, 959 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cuzzocrea, Salvatore: 59 articles (08/2021 - 02/2003)
2.	Hazen, Stanley L: 48 articles (01/2018 - 11/2002)
3.	Di Paola, Rosanna: 43 articles (04/2021 - 02/2003)
4.	Mazzon, Emanuela: 41 articles (11/2011 - 02/2003)
5.	Genovese, Tiziana: 33 articles (08/2021 - 09/2003)
6.	Verri, Waldiceu A: 30 articles (03/2022 - 06/2008)
7.	Chen, John W: 28 articles (01/2022 - 11/2004)
8.	Heeringa, Peter: 28 articles (01/2022 - 10/2002)
9.	Suzuki, Kazuo: 27 articles (08/2019 - 01/2002)
10.	Sener, Göksel: 27 articles (05/2014 - 06/2002)

Related Diseases

1.	Colitis 01/01/2021 - "Mice treated with pNAPE-LP showed a significant improvement of colitis in terms of histological damage score, macrophage count, and myeloperoxidase levels (-53, -82, and -70.4%, respectively). " 01/01/2018 - "Here, with oral AD-lico™ administration, there was a substantial disruption of the colonic architectural changes due to DSS and a significant reduction in colonic myeloperoxidase (MPO) activity, a marker of colitis. " 02/01/2014 - "DSS-induced colitis clearly induced Myeloperoxidase activity in the colon, which was significantly reduced by treatments with 3% DSS-pGLP-2 or 3% DSS-PEG-pGLP-2. These results showed that site-specific Lys(30)-PEG-GLP-2 was resistant to degradation and reduced the severity of colonic injury in murine colitis. " 01/01/2007 - "Both probiotics showed intestinal anti-inflammatory effects in this model of experimental colitis, as evidenced histologically and by a significant reduction of colonic myeloperoxidase activity (P<0.05). " 02/01/2006 - "Histologic scores of colonic damage and myeloperoxidase activity were lower in both probiotic-treated groups compared with those of the colitis control group (P<0.001), although the mentioned scores improved significantly more in the high-EPS group than in the low-EPS group (P<0.001). "
2.	Inflammation (Inflammations) 01/24/2014 - "In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. " 03/01/2016 - "The results demonstrated that A‑769662 attenuated the LPS‑induced acute inflammation in the heart and lung tissue, as indicated by the significant reduction in myeloperoxidase activity (P<0.001) and inhibition of tissue damage. " 01/01/2016 - "The TG gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model." 12/01/2013 - "The reduction in local inflammation from the two-week course of VSL#3 is correlated to a significant reduction in levels of active IL-1β, and tissue levels of myeloperoxidase. " 02/15/2013 - "Additionally, inflammation of the colon determined by the number of myeloperoxidase-positive cells and colonic transit time were significantly improved in aly/aly mice, FTY720-treated wild-type mice, and in MLN ex mice. "
3.	Edema (Dropsy) 12/01/2021 - "Moreover, OIP5-AS1 overexpression relieved lung edema, lung epithelial cell apoptosis, infiltration of myeloperoxidase (MPO)-labeled polymorphonuclear neutrophils (PMN), inflammatory responses triggered by CLP in vivo. " 10/01/2017 - "Both doses of copaiba oil improved the paw edema and the dose of 0.58 mg · kg-1 improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (-30%) of arthritic rats. " 10/01/2023 - "Incubation with EAELSt decreased the amount of DPPH radical (EC50 of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200-500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. " 01/01/2023 - "Topically administered NMP, at doses of 0.03 - 0.50 mg/ear, reduced TPA-induced ear edema and neutrophil migration, as evidenced by low tissue myeloperoxidase activity and verified by histological examination. " 10/26/2021 - "In the paw edema assay, EOO-βCD-K reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. "
4.	Body Weight (Weight, Body) 01/01/2021 - "RA-loaded nanovesicles improved body weight loss and disease activity index as well as increased mucus production and decreased myeloperoxidase activity and TNF-α production. " 08/01/2006 - "Both Cur and Dex improved body weight loss, ameliorated histological images and decreased macroscopic score and myeloperoxidase activity. " 03/17/2023 - "The results showed that L. plantarum Δbsh 1 and Δbsh 3 treatments did not improve body weight and alleviate the hyperactivated myeloperoxidase activity to the DSS group. " 02/01/2019 - "The results indicated that treatment with EVO ameliorated DSS-induced UC mice body weight loss, disease activity index (DAI), colon length shortening, colonic pathological damage, and myeloperoxidase (MPO) activity. " 01/01/2019 - "Specifically, PRDX4-/y mice showed marked body weight loss and shortening of colon length compared to WT mice, whereas the myeloperoxidase levels were increased in PRDX4-/y compared to WT mice. "
5.	Lung Injury 11/01/2022 - "Biological investigations indicated that BAP31 deficiency could significantly alleviated lung injury, as evidenced by the improved histopathological morphology, reduced pulmonary wet/dry weight ratio, inhibited myeloperoxidase level and decreased neutrophil counts in the bronchoalveolar lavage fluid. " 05/01/2022 - ": The results show that PHC attenuates rI/R-mediated lung injury indices, myeloperoxidase, and apoptosis in vivo. " 12/20/2021 - "The wet/dry weight ratio (W/D) and myeloperoxidase (MPO) activity in the lung tissues were measured, and HE staining was used to evaluate lung pathologies and determine lung injury score of the rats. " 08/28/2021 - "In the LPS lung injury model, RGS5-/- mice also failed to recruit neutrophils into the lung, which was accompanied by reduced tissue myeloperoxidase levels after 24 h. " 05/27/2020 - "SLBZS decreased bacterial load, reduced wet/dry weight ratio, inhibited myeloperoxidase activity, reduced the neutrophils count, and ameliorated lung injury. "

Related Drugs and Biologics

1.	Antineutrophil Cytoplasmic Antibodies (ANCA)
2.	Proteins (Proteins, Gene)
3.	Malondialdehyde (Propanedial)
4.	Cytokines
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Glutathione (Reduced Glutathione)
7.	Catalase
8.	Superoxide Dismutase
9.	Antioxidants
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Aftercare (After-Treatment)
4.	Plasma Exchange
5.	Drug Therapy (Chemotherapy)