Myelofibrosis (Myelosclerosis)

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1156 relevant articles (66 outcomes, 83 trials/studies) found for this Disease

Description: Replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another, unrelated condition. (Dorland, 27th ed)

Also Known As:

Myelosclerosis; Bone Marrow Fibroses; Fibroses, Bone Marrow; Myelofibroses; Myeloscleroses; Bone Marrow Fibrosis; Fibrosis, Bone Marrow

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Hematologic Diseases: 1420

Bone Marrow Diseases: 60

Myeloproliferative Disorders: 915

Myelofibrosis: 1156

Related Diseases

1.	Myeloid Metaplasia (Agnogenic Myeloid Metaplasia)
2.	Splenomegaly
3.	Anemia
4.	Thrombocytopenia (Thrombopenia)
5.	Pancytopenia

Experts

1.	Tefferi, Ayalew: 18 articles (05/2008 - 03/2002)
2.	Mesa, Ruben A: 14 articles (05/2008 - 03/2002)
3.	Tefferi, A: 12 articles (08/2008 - 04/2000)
4.	Mesa, R A: 10 articles (08/2008 - 04/2000)
5.	Li, Chin-Yang: 7 articles (04/2006 - 03/2002)
6.	Hoffman, Ronald: 6 articles (10/2008 - 05/2005)
7.	Bock, Oliver: 6 articles (04/2008 - 04/2004)
8.	Kvasnicka, H M: 6 articles (04/2007 - 01/2000)
9.	Thiele, J: 6 articles (04/2007 - 01/2000)
10.	Barosi, Giovanni: 6 articles (03/2006 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myelofibrosis:

1.	imatinib (Gleevec)FDA Link 05/20/2008 - "Nevertheless, imatinib mesylate induced rapid and complete hematological responses in treated FIP1L1-PDGFRalpha cases, followed by molecular remission and reversal of myelofibrosis" 11/01/2002 - "We present a CML patient in megakaryoblastic crisis with severe myelofibrosis, who was treated with imatinib at a dosage of 400 mg/day and achieved complete remission together with a marked regression of myelofibrosis after 1 month" 08/15/2005 - "METHODS: The current study evaluated the significance of the degree of pretreatment myelofibrosis on response and survival with imatinib therapy in patients with newly diagnosed CML" 04/01/2008 - "We present a case of Philadelphia positive chronic idiopathic myelofibrosis that had no obvious response to imatinib." 06/01/2007 - "Reappearance of t(12;17)-positive primary myelofibrosis following Ph+ CML cell reduction by imatinib]" Order ALL the reference details at left...
2.	Thalidomide (Thalomid)FDA Link 07/01/2008 - "Low-dose thalidomide in myelofibrosis." 02/01/2007 - "Mini-dose of thalidomide for treatment of primary myelofibrosis" 07/01/2004 - "Myelofibrosis: thalidomide finds a new disease." 01/01/2004 - "Thalidomide for the treatment of idiopathic myelofibrosis." 11/01/2001 - "Thalidomide in agnogenic and secondary myelofibrosis." Order ALL the reference details at left...
3.	Hydroxyurea (Hydrea)FDA LinkGeneric 01/01/1990 - "We found a significant reduction of bone marrow fibrosis, believed to be mediated by suppression of thrombopoiesis by hydroxyurea." 11/01/2003 - "We describe a 63-yr-old patient diagnosed with chronic idiopathic myelofibrosis whose disease was treated with hydroxyurea for 2 yr. He developed respiratory symptoms that were extensively investigated including lung biopsy" 07/01/2000 - "In contrast, a considerable number of patients displayed a regression of myelofibrosis after hydroxyurea treatment" 06/01/2000 - "Hydroxyurea treatment was started for myelofibrosis" 05/01/1995 - "An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis." Order ALL the reference details at left...
4.	Iron (Serum Iron Level)IBA 12/01/2000 - "Detection of both increased CD68-positive histiocytes by immunohistochemistry and iron-stained phagocytic cells in marrow biopsy specimens appeared to be helpful for diagnosis of HPS in this patient, whose marrow showed myelofibrosis with hypocellularity." 12/01/1989 - "The iron kinetic model described by Ricketts et al was used to study haemopoiesis in chronic myelofibrosis" 04/01/2004 - "Moreover, besides myelofibrosis in a number of patients the interstitial compartment displays a remarkable inflammatory reaction with lymphoid nodules, abundant iron-laden macrophages, perivascular plasmacytosis and increase in microvessels" 05/01/1998 - "METHODS: To verify whether DFO influences proliferation of erythropoietic precursors, we studied 10 patients on chronic haemodialysis, free from malignancies or other haematological diseases, iron deficiency, bone marrow fibrosis, and Al toxicity" 07/01/1996 - "Iron deficiency and mild myelofibrosis were found in one patient each" Order ALL the reference details at left...
5.	Cytarabine (Cytosar-U)FDA LinkGeneric 10/01/1984 - "Low dose cytosine arabinoside used to induce remission in acute myelofibrosis." 06/01/1994 - "Successful treatment of low dose cytosine arabinoside for acute myelofibrosis with immature myeloblast (AML-MO)" 11/01/1992 - "A 31-year-old man with primary myelofibrosis initially received low dose Ara C" 06/01/1988 - "Megakaryoblastic leukemia (acute myelofibrosis): complete remission of a case with low-dose cytosine arabinoside]" 05/01/2003 - "Successful treatment with intermediate dose cytosine arabinoside for myelodysplastic syndrome with acute myelofibrosis." Order ALL the reference details at left...
6.	InterferonsIBA 01/01/1997 - "Recent reports of cytogenetic remission and reversal of bone marrow fibrosis after interferon therapy are of interest" 01/01/2004 - "Following this calculation no relevant differences in the evolution of myelofibrosis were evident in the various therapy groups especially not following interferon treatment" 10/23/1993 - "Alpha-2b interferon constitutes an effective therapy for a selected number of patients with idiopathic myelofibrosis" 10/23/1993 - "Four patients out of a total of 12 diagnosed with idiopathic myelofibrosis over a period of 3 years were selected for interferon treatment" 06/08/1992 - "Treatment with Epo for ten months combined with treatment with interferon for six months resulted in normalization of the haemoglobin concentration in one patient with bone-marrow insufficiency on account of primary myelofibrosis" Order ALL the reference details at left...
7.	AndrogensIBA 01/01/1966 - "Physiopathological and cytogenetic investigations of a case of myelofibrosis treated successfully with androgens]" 02/01/1978 - "This brief case report describes a sustained haematological remission obtained in a patient with primary myelofibrosis treated by bone marrow curettage after previous therapy with androgens was unsuccessful" 06/01/2005 - "Androgens are considered the treatment of choice for the anaemia of myelofibrosis with myeloid metaplasia (MMM)" 07/14/1978 - "The results of this study suggest that androgens might be of value in advanced cases of myelofibrosis with transfusion-requiring anemia or severe thrombocytopenia." 04/02/1977 - "Ten patients with bone-marrow failure from myelofibrosis, aplastic anaemia, paroxysmal nocturnal haemoglobinuria, and "hairy cell" leukaemia, who had failed to respond to androgens and/or glucocorticosteroids, were treated with a combination of aetiocholanolone and prednisolone" Order ALL the reference details at left...
8.	Busulfan (Busulfex)FDA Link 02/01/1989 - "Remission of chronic idiopathic myelofibrosis to busulphan treatment." 05/01/1988 - "Remission of chronic idiopathic myelofibrosis to busulfan treatment." 09/01/1990 - "The busulfan pulse therapy, therefore, appears to be a treatment of choice in idiopathic myelofibrosis." 09/01/1990 - "We report here a patient of myelofibrosis treated successfully by busulfan pulse therapy which was reported first by chang et al in 1988" 09/01/1990 - "Successful treatment of primary myelofibrosis by busulfan pulse therapy: report of a case]" Order ALL the reference details at left...
9.	Danazol (Azol)FDA LinkGeneric 04/01/2002 - "We report here a case of remission of myelodysplastic syndrome with myelofibrosis in transformation after danazol therapy in a 72-yr-old man" 01/01/1990 - "Clinical and hematological improvement in a patient receiving danazol therapy for myelofibrosis with myeloid metaplasia." 06/01/2005 - "Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: long-term results in 30 patients." 06/01/2000 - "Danazol treatment of idiopathic myelofibrosis with severe anemia." 01/01/1990 - "We report the positive effect of danazol on clinical and hematological data in a patient with myelofibrosis and myeloid metaplasia" Order ALL the reference details at left...
10.	Azathioprine (Imuran)FDA LinkGeneric 08/01/1992 - "When this girl was subsequently treated with high dose steroid and azathioprine her myelofibrosis went into remission." 02/01/1995 - "Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine]" 01/01/1969 - "Animal experimental production of bone marrow fibroses using repeated injections of foreign protein and their medicamentous influencing through azathioprine and prednisolone]" Order ALL the reference details at left...

Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 11/01/1992 - "These results demonstrate that bone marrow transplantation is effective for primary myelofibrosis for which there is no otherwise curative therapy." 09/30/1982 - "The method was used to study suppressor activity of a patient who was treated by bone marrow transplantation for myelofibrosis" 12/01/1995 - "The published experience of allogeneic bone marrow transplantation for primary myelofibrosis (PMF) is limited" 12/01/1995 - "Allogeneic bone marrow transplantation for primary myelofibrosis." 07/01/1995 - "We report a case of a 48-year-old female with postpolycythemic myelofibrosis successfully treated with allogeneic HLA-matched bone marrow transplantation." Order ALL the reference details at left...
2.	Transplants (Transplant) 07/01/2002 - "Nine patients (seven with AML/MDS, two with myelofibrosis) died of transplant-related complications, and 16 are surviving, 14 of them in continuous unmaintained remission" 02/01/2000 - "We believe that this is the first report to provide clear evidence for the efficacy of DLI in this setting, which also provides evidence for the existence of a T-cell-mediated 'graft vs. myelofibrosis' effect similar to that seen against other haematological malignancies." 04/01/2004 - "Transplant strategies for idiopathic myelofibrosis." 04/01/2002 - "Syngeneic stem cell transplant for spent-phase polycythaemia vera: eradication of myelofibrosis and restoration of normal haematopoiesis." 02/01/2001 - "Seven patients (six with AML/MDS and one with myelofibrosis) died of transplant-related complications" Order ALL the reference details at left...
3.	Stem Cell Transplantation 10/01/2008 - "In this study, we evaluated the outcome of patients with myelofibrosis who underwent allogeneic stem cell transplantation, and the impact of prognostic factors" 11/01/2007 - "CONCLUSION: This study shows that allogeneic stem cell transplantation after reduced-intensity conditioning resulted in rapid regression of bone-marrow fibrosis." 10/01/2008 - "Relapse of postpolycythemia myelofibrosis after allogeneic stem cell transplantation in a polycythemic phase: successful treatment with donor lymphocyte infusion directed by quantitative PCR test for V617F-JAK2 mutation." 10/01/2008 - "Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation." 04/01/2008 - "Changes in spleen size postallogeneic haematopoietic stem cell transplantation (HSCT) in patients with primary myelofibrosis have been poorly characterized" Order ALL the reference details at left...
4.	Transplantation (Transplant Recipients) 08/01/2004 - "Long-term remission of myelofibrosis following nonmyeloablative allogeneic peripheral blood progenitor cell transplantation in older age: the Scripps Clinic experience." 10/01/2004 - "Six months after transplantation, trephin biopsies were made and a complete regression of bone marrow fibrosis was documented" 07/01/2004 - "Deciding on transplantation for myelofibrosis: setting the record straight." 01/01/2000 - "The patient remains alive 8 months post-PBSCT, and bone marrow fibrosis has significantly decreased following transplantation" 11/15/1981 - "In view of the absence of other effective therapy, intensive therapy with marrow transplantation should be considered as primary therapy for patients with acute myelosclerosis who have a suitable marrow donor." Order ALL the reference details at left...
5.	Splenectomy 01/01/1974 - "A case of myelofibrosis improved after splenectomy (author's transl)]" 02/01/2008 - "Major morbidity after laparoscopic splenectomy was mostly related to surgery for myelofibrosis" 08/01/2001 - "Between 1992 and 1999, 5 patients with chronic idiopathic myelofibrosis (MF) underwent splenectomy at our hospital" 08/01/2001 - "Splenectomy in 5 patients with idiopathic myelofibrosis]" 04/01/1999 - "Splenectomy for myelofibrosis has been associated with an increased postoperative complication rate" Order ALL the reference details at left...

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