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Transverse Myelitis (Necrotizing Myelitis)

Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)
Also Known As:
Necrotizing Myelitis; Acute Transverse Myelitis; Myelitis, Transverse; Myelitis, Acute Transverse; Myelitis, Necrotizing; Myelitis, Paraneoplastic; Myelitis, Postinfectious; Myelitis, Postvaccinal; Myelitis, Subacute Transverse; Postinfectious Myelitis; Transverse Myelopathy Syndrome; Myelitides, Subacute Transverse; Myelitis, Demyelinative; Paraneoplastic Myelitis; Postvaccinal Myelitis; Subacute Transverse Myelitis; Transverse Myelitis, Acute; Transverse Myelitis, Subacute; Transverse Myelopathy Syndromes; Demyelinative Myelitis
Networked: 673 relevant articles (37 outcomes, 34 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Optic Neuritis (Retrobulbar Neuritis)
2. Multiple Sclerosis
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Neuromyelitis Optica (Devic's Disease)
5. Neuralgia (Stump Neuralgia)

Experts

1. Palace, Jacqueline: 12 articles (05/2022 - 04/2007)
2. Pittock, Sean J: 12 articles (01/2021 - 01/2006)
3. Levy, Michael: 10 articles (10/2022 - 05/2008)
4. Wingerchuk, Dean M: 9 articles (01/2021 - 01/2006)
5. Weinshenker, Brian G: 9 articles (01/2020 - 01/2006)
6. Jarius, Sven: 9 articles (01/2018 - 04/2007)
7. Reindl, Markus: 8 articles (01/2021 - 09/2011)
8. Leite, Maria Isabel: 7 articles (01/2022 - 07/2008)
9. Waters, Patrick: 7 articles (11/2021 - 04/2008)
10. Dale, Russell C: 7 articles (01/2021 - 06/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Transverse Myelitis:
1. SteroidsIBA
2. Immunoglobulin G (IgG)IBA
3. Cyclophosphamide (Cytoxan)FDA LinkGeneric
4. AntibodiesIBA
5. Prednisolone (Predate)FDA LinkGeneric
6. Adrenal Cortex Hormones (Corticosteroids)IBA
7. Acyclovir (Aciclovir)FDA LinkGeneric
8. Myelin-Oligodendrocyte GlycoproteinIBA
9. Antiphospholipid AntibodiesIBA
10. Oligoclonal BandsIBA
09/01/2003 - "Idiopathic RTM might be a disease entity distinct from MSRTM, differing in its male preponderance, absence of oligoclonal bands, frequent multiple relapses, and frequent presentation as acute transverse myelitis."
12/17/2014 - "Disease started with relapsing optic neuritis and an episode of longitudinally extensive transverse myelitis (LETM) in the absence of any brain MRI lesions or cerebrospinal fluid-restricted oligoclonal bands. "
10/01/2002 - "Devic disease is characterized by an attack or attacks of optic neuritis and necrotizing myelitis without clinical or magnetic resonance imaging (MRI) evidence of brain involvement or presence of oligoclonal bands in the cerebrospinal fluid (CSF). "
06/01/2009 - "Studies of children after a first episode of demyelination have identified disease onset in adolescence, intrathecal oligoclonal bands and optic neuritis as associated with a higher MS risk, whereas prepubertal onset, presence of polyfocal features with encephalopathy, and transverse myelitis have been associated with a lower risk of subsequent MS. The relapsing-remitting form of MS accounts for over 96% of all MS in children. "
03/01/2005 - "Here, we report a case of acute transverse myelitis in a woman developing 4 years after documented HCV seropositivity, associated with intrathecal anti-HCV protein IgG. Isoelectrofocusing of all CSF samples before and after immunoabsorption with recombinant structural HCV proteins revealed disappearance or marked decrease of some oligoclonal IgG bands suggesting binding to HCV proteins. "

Therapies and Procedures

1. Therapeutics
2. Plasma Exchange
3. Plasmapheresis
4. Immunotherapy
5. Aftercare (After-Treatment)