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Myelitis

Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.
Also Known As:
Infectious Myelitis; Inflammation, Spinal Cord; Subacute Necrotising Myelitis; Inflammations, Spinal Cord; Inflammatory Myelopathies; Inflammatory Myelopathy; Myelitides; Myelitis, Infectious; Myelitis, Subacute Necrotising; Myelopathies, Inflammatory; Necrotising Myelitis, Subacute; Spinal Cord Inflammations; Myelopathy, Inflammatory; Spinal Cord Inflammation
Networked: 440 relevant articles (20 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Multiple Sclerosis
2. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
3. Encephalitis (Encephalitis, Rasmussen)
4. Herpes Zoster
5. Optic Neuritis (Retrobulbar Neuritis)

Experts

1. Cuzzocrea, Salvatore: 31 articles (01/2014 - 02/2005)
2. Mazzon, Emanuela: 29 articles (01/2012 - 02/2005)
3. Bramanti, Placido: 26 articles (01/2012 - 02/2005)
4. Di Paola, Rosanna: 23 articles (01/2014 - 01/2006)
5. Genovese, Tiziana: 23 articles (01/2011 - 02/2005)
6. Esposito, Emanuela: 22 articles (01/2014 - 07/2006)
7. Muià, Carmelo: 14 articles (08/2008 - 02/2005)
8. Crisafulli, Concetta: 13 articles (02/2010 - 01/2006)
9. Paterniti, Irene: 11 articles (01/2014 - 05/2009)
10. Impellizzeri, Daniela: 7 articles (01/2014 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myelitis:
1. Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/01/2013 - "In particular, PEA was less effective in PPAR-αKO, GSK0660-treated or GW9662-pretreated mice, as evaluated by the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, proinflammmatory cytokine, inducible nitric oxide synthase expression and motor function. "
01/01/2012 - "In particular, simvastatin was less effective in PPAR-α KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation, neutrophil infiltration, nitrotyrosine formation, pro-inflammmatory cytokine expression, nuclear factor (NF)-κB activation, inducible nitric-oxide synthase (iNOS) expression, and apoptosis. "
05/01/2009 - "In particular, DEX was less effective in PPAR-alphaKO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, nitrotyrosine formation, pro-inflammatory cytokine expression, NF-kappaB activation, inducible nitric-oxide synthase (iNOS) expression; and apoptosis. "
07/01/2008 - "Repeated PEA administration (10 mg/kg i.p.; 30 min before and 1 and 6 h after SCI) significantly reduced: 1) the degree of spinal cord inflammation and tissue injury, 2) neutrophil infiltration, 3) nitrotyrosine formation, 4) proinflammatory cytokine expression, 5) nuclear transcription factor activation-kappaB activation, 6) inducible nitric-oxide synthase expression, and 6) apoptosis. "
05/01/2010 - "GW0742 treatment (0.3 mg kg(-1) i.p.) 1 and 6 h after the SCI significantly reduced 1) the degree of spinal cord inflammation and tissue injury (histological score), 2) neutrophil infiltration (myeloperoxidase activity), 3) nitrotyrosine formation, 4) proinflammatory cytokines expression, 5) nuclear factor-kappaB activation, 6) inducible nitric-oxide synthase expression, and 6) apoptosis (terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, FasL, Bax, and Bcl-2 expression). "
2. Immunoglobulins (Immunoglobulin)IBA
3. Peroxisome Proliferator-Activated Receptors (PPAR)IBA
4. 3-nitrotyrosineIBA
5. AntibodiesIBA
6. Imidazoline ReceptorsIBA
7. IdazoxanIBA
8. LigandsIBA
9. 2-(2-benzofuranyl)-2-imidazolineIBA
10. Acyclovir (Aciclovir)FDA LinkGeneric

Therapies and Procedures

1. Plasmapheresis
2. Immunotherapy
3. Immunomodulation
4. Drug Therapy (Chemotherapy)
5. Transplants (Transplant)