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Myelitis

Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.
Also Known As:
Infectious Myelitis; Inflammation, Spinal Cord; Inflammations, Spinal Cord; Inflammatory Myelopathies; Inflammatory Myelopathy; Myelitides; Myelitides, Subacute Necrotizing; Myelitis, Infectious; Myelitis, Subacute Necrotizing; Myelopathies, Inflammatory; Necrotizing Myelitides, Subacute; Necrotizing Myelitis, Subacute; Spinal Cord Inflammations; Subacute Necrotizing Myelitides; Myelopathy, Inflammatory; Spinal Cord Inflammation; Subacute Necrotizing Myelitis
Networked: 866 relevant articles (51 outcomes, 33 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Encephalitis (Encephalitis, Rasmussen)
2. Demyelinating Diseases (Demyelinating Disease)
3. Optic Neuritis (Retrobulbar Neuritis)
4. Herpes Zoster
5. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)

Experts

1. Cuzzocrea, Salvatore: 31 articles (01/2014 - 02/2005)
2. Mazzon, Emanuela: 29 articles (04/2012 - 02/2005)
3. Bramanti, Placido: 26 articles (04/2012 - 02/2005)
4. Di Paola, Rosanna: 23 articles (01/2014 - 01/2006)
5. Genovese, Tiziana: 23 articles (04/2011 - 02/2005)
6. Esposito, Emanuela: 22 articles (01/2014 - 07/2006)
7. Takahashi, Toshiyuki: 17 articles (12/2022 - 02/2008)
8. Muià, Carmelo: 14 articles (08/2008 - 02/2005)
9. Flanagan, Eoin P: 13 articles (12/2021 - 02/2016)
10. Pittock, Sean J: 13 articles (01/2021 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myelitis:
1. SteroidsIBA
2. AntibodiesIBA
3. CytokinesIBA
4. Adrenal Cortex Hormones (Corticosteroids)IBA
5. Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
02/01/2013 - "In particular, PEA was less effective in PPAR-αKO, GSK0660-treated or GW9662-pretreated mice, as evaluated by the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, proinflammmatory cytokine, inducible nitric oxide synthase expression and motor function. "
10/01/2017 - "In particular, melatonin was less effective in PPAR-α KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, pro-inflammatory cytokine expression, nuclear factor κB (NF-κB) activation, and inducible nitric oxide synthase (iNOS) expression. "
04/26/2012 - "In particular, simvastatin was less effective in PPAR-α KO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation, neutrophil infiltration, nitrotyrosine formation, pro-inflammmatory cytokine expression, nuclear factor (NF)-κB activation, inducible nitric-oxide synthase (iNOS) expression, and apoptosis. "
05/01/2009 - "In particular, DEX was less effective in PPAR-alphaKO, compared to WT mice, as evaluated by inhibition of the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, nitrotyrosine formation, pro-inflammatory cytokine expression, NF-kappaB activation, inducible nitric-oxide synthase (iNOS) expression; and apoptosis. "
07/01/2008 - "Repeated PEA administration (10 mg/kg i.p.; 30 min before and 1 and 6 h after SCI) significantly reduced: 1) the degree of spinal cord inflammation and tissue injury, 2) neutrophil infiltration, 3) nitrotyrosine formation, 4) proinflammatory cytokine expression, 5) nuclear transcription factor activation-kappaB activation, 6) inducible nitric-oxide synthase expression, and 6) apoptosis. "
6. Immunoglobulins (Immunoglobulin)IBA
7. Peroxisome Proliferator-Activated Receptors (PPAR)IBA
8. MethylprednisoloneFDA LinkGeneric
9. Immunoglobulin G (IgG)IBA
10. VaccinesIBA

Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Immunotherapy
4. Plasma Exchange
5. Plasmapheresis