Mycoses (Diseases, Fungus)

Diseases caused by FUNGI.

Also Known As:

Diseases, Fungus; Fungal Diseases; Fungal Infections; Fungus Infections; Disease, Fungal; Disease, Fungus; Diseases, Fungal; Fungal Disease; Fungal Infection; Fungus Disease; Fungus Infection; Infection, Fungal; Infection, Fungus; Infections, Fungal; Infections, Fungus; Fungus Diseases

Networked: 11300 relevant articles (760 outcomes, 1105 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Neoplasms (Cancer)
3.	Candidiasis (Moniliasis)
4.	Aspergillosis
5.	Mycoses (Diseases, Fungus)

Experts

1.	Cornely, Oliver A: 44 articles (10/2021 - 05/2003)
2.	Kontoyiannis, Dimitrios P: 41 articles (06/2022 - 11/2003)
3.	Walsh, Thomas J: 41 articles (01/2022 - 01/2002)
4.	Perfect, John R: 38 articles (06/2022 - 01/2002)
5.	Lass-Flörl, Cornelia: 31 articles (03/2022 - 10/2005)
6.	Maertens, Johan: 28 articles (12/2020 - 09/2005)
7.	Netea, Mihai G: 27 articles (07/2022 - 01/2004)
8.	Herbrecht, Raoul: 26 articles (04/2022 - 04/2003)
9.	Groll, Andreas H: 26 articles (01/2022 - 03/2002)
10.	Casadevall, Arturo: 25 articles (01/2021 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mycoses:

1.	Amphotericin B (Amphotericin)FDA LinkGeneric 08/01/2002 - "Amphotericin B is well established as a highly efficacious agent against systemic fungal infections in humans. " 12/01/2000 - "Amphotericin B is the gold standard for antifungal treatment for the most severe mycoses. " 11/01/1989 - "Amphotericin B is the most effective agent for the majority of systemic fungal infections but often causes toxicity, and specific dosage guidelines for amphotericin B in pediatric patients are lacking. " 05/03/2022 - "Although Amphotericin B (AmB) is considered as the "gold standard" treatment for deep fungal infections, owing to its excellent antifungal effect, it often causes severe hemolytic toxicity and nephrotoxicity, which limits its clinical use. " 01/01/1992 - "Recovery from fungal infection in this group of patients occurred when there was complete remission of underlying disease and recovery of neutrophil counts, when concurrently treated by liposomal amphotericin."
2.	Fluconazole (Zonal)FDA LinkGeneric 06/01/1998 - "Fluconazole is active in vitro against the most common pathogens, penetrates into the nail bed, and is clinically effective in the treatment of a wide variety of fungal infections. " 10/01/2000 - "However, fluconazole was very effective in reducing superficial fungal infections (OR, 0.44; 95% CI, 0.24-0.80), even when it was given in lower doses (50-200 mg per day). " 06/01/1998 - "Fluconazole has proven to be safe and effective for a variety of superficial and systemic fungal infections. " 01/01/1999 - "Fluconazole can rapidly penetrate from plasma into the female genital organs, supporting high efficacy of fluconazole against fungal infections in the field of gynecology." 03/01/2015 - "Considering that C18H12S2IBr is more active at lower concentrations and has comparable toxic effects to fluconazole in rats, this new compound shows some promise in the treatment of fungal infections. "
3.	Itraconazole (Sporanox)FDA LinkGeneric 07/01/1997 - " non comparable clinical trials, Itraconazole was shown to be extremely effective in a wide range of superficial and more serious deep fungal infections when administered once or twice daily. " 03/01/1989 - "It is a potent inhibitor of most human fungal pathogens including Aspergillus sp. In non-comparative clinical trials itraconazole was shown to be extremely effective in a wide range of superficial and more serious 'deep' fungal infections when administered once or twice daily. " 04/01/2001 - "Although itraconazole prophylaxis significantly reduced the number and time to development of oral candidosis, too few episodes of deep fungal infection were noted to determine whether itraconazole prophylaxis was effective for this condition. " 07/01/2013 - "Itraconazole is widely used for the treatment of endemic fungal infections. " 09/01/2005 - "These have confirmed that itraconazole is effective in this setting in reducing the rate of systemic fungal infections. "
4.	Antifungal AgentsIBA 07/01/2010 - "Although superficial fungal infections of the skin and nails are common and are for the most part treated successfully with existing antifungal agents, serious fungal infections are becoming a growing danger for human health. " 01/01/2008 - "The model described here may present more similar conditions to clinical fungal infections; therefore the results such as MIC may be more helpful for hiring the most effective antifungal agent." 11/01/2001 - "With the continuing increase in clinically important fungal disease, especially seen in the neutropenic patient, the need for new and improved systemic antifungal agents marches on. " 04/01/1999 - "Improved understanding of new and established antifungal agents in conjunction with ART agents as well as immune modulators, should yield important advances in prevention, control and treatment of fungal infections of HIV infected people." 06/15/2008 - "In general, mortality rates associated with systemic fungal infections have not improved much in more than a decade, although the number of antifungal agents available for the treatment of serious fungal infections has increased in the past few years. "
5.	liposomal amphotericin B FDA Link 01/01/2010 - "Amphotericin B lipid complex represents a valuable therapeutic option in the treatment of fungal infections but improved strategies for the management of infusion-related adverse events are required." 09/01/1998 - "AmBisome administered to febrile neutropenic patients in this study was well tolerated, was seldom associated with infusion-related toxicity, was characterized by nonlinear saturation kinetics, and was effective in preventing breakthrough fungal infections." 05/11/2022 - "However, liposomal amphotericin-B should be preferred in these patients as prophylactic rather than therapeutic treatment for fungal infections." 02/01/2003 - "Twenty-eight cases of other deep fungal infections treated with Ambisome were clinically cured with an effective rate of 92%, within a mean course of 19.3 days, by a mean cumulative dose of 907.5 mg, and fungal clearance rate on the second and third month was 75 and 92%, respectively. " 02/01/2001 - "ABLC and AmBisome were equally effective for the treatment of suspected or documented fungal infections. "
6.	Ketoconazole (Nizoral)FDA LinkGeneric 12/01/1983 - "1981 a new systemic antifungal drug Ketoconazole is available in the Federal Republic of Germany that has proven effective even in severe cases with fungal infections. " 02/01/1983 - "Ketoconazole has a distinct advantage in that it is a relatively nontoxic oral agent and may prove very effective in treating non-life-threatening chronic fungal infections. " 02/01/2015 - "Although oral ketoconazole is effective in treating fungal infections, the potential for drug interactions, endocrine dysregulation, and hepatotoxicity may outweigh its benefits. " 03/23/2005 - "Ketoconazole, an anti-fungal agent, is often incorporated in several pharmaceutical forms and in shampoo formulation it is known to be effective against fungal infection on the scalp. " 06/01/1998 - "Oral ketoconazole has been shown to be effective in a variety of cutaneous fungal infections. "
7.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2020 - "Although many bacterial and fungal infections can be successfully cured by commonly used antibiotics, a new threat emerges in the form of microbial resistance. " 10/01/2006 - "Only a few antibiotics are effective in the treatment of fungal infections. " 04/01/1979 - "Polyene antibiotics are still very useful in the treatment of Candida mycoses. " 10/29/2019 - "Failure of clinical improvement with antibiotics should raise the suspicion of a fungal infection. " 01/01/2023 - "The present study aimed to determine the prevalence of bacterial and fungal infections of the eye and also to assess the antibiotic susceptibility pattern of bacterial isolates at a tertiary referral eye care hospital in Bari, Italy. "
8.	Voriconazole (Vfend)FDA LinkGeneric 02/26/2013 - "Voriconazole therapeutic drug levels were not associated with improvement in clinical outcomes among patients with proven or probable invasive fungal disease. " 09/01/2007 - "Seventy-one allograft recipients receiving voriconazole, in whom complete clinical, microbiologic and pharmacokinetic data were available, were studied to determine the efficacy of voriconazole in preventing fungal infections. " 02/24/2014 - "More patients died in the voriconazole group and a claimed significant reduction in the number of breakthrough fungal infections disappeared when patients arbitrarily excluded from the analysis by the trial authors were included. " 01/01/2012 - "Given high index of suspicion for fungal disease in an immunocompromised host, empiric antifungals were discontinued and voriconazole initiation resulted in a successful therapy. " 01/25/2006 - "More patients died in the voriconazole group and a claimed significant reduction in the number of breakthrough fungal infections disappeared when patients arbitrarily excluded from analysis by the authors were included. "
9.	posaconazole FDA Link 02/01/2014 - "Prior clinical trials have demonstrated efficacy and effectiveness of posaconazole in the prophylaxis of invasive fungal diseases in high-risk patients. " 11/01/2013 - "Our data suggest that posaconazole was effective in reducing the rate and probability of invasive fungal disease in high-risk patients." 01/01/2008 - "Posaconazole prophylaxis during periods of high risk was recently demonstrated to be effective in preventing fungal infections and associated mortality. " 02/14/2018 - "Conclusion: Posaconazole is safe and effective for primary prevention of fungal infection of SAA patients receiving IST, especially for the VSAA. " 01/01/2018 - "Expert Commentary: Posaconazole has proved safe and effective in preventing and treating fungal infections in immunocompromised children. "
10.	Terbinafine (Lamisil)FDA LinkGeneric 08/01/2021 - "As proven in clinical trials, superficial fungal infections can be effectively treated by single topical application of terbinafine hydrochloride (Ter-HCl) in a film forming system (FFS). " 09/01/2009 - "Terbinafine is effective against fungal infections of the nail. " 05/01/2010 - "To evaluate the in vitro efficacy of terbinafine activity against filamentous fungi and yeasts that cause mycoses. " 05/01/2010 - "Evaluation of the disk-diffusion method to determine the in vitro efficacy of terbinafine against subcutaneous and superficial mycoses agents." 04/01/1997 - "Controlled single- or double-blind studies were evaluated to describe the efficacy of terbinafine in the treatment of various fungal infections. "

Therapies and Procedures

1.	Therapeutics 01/10/2018 - "This case highlighted the importance of early consideration of fungal infection in patients with multiple risk factors and the need for aggressive therapy to ensure the best outcome." 03/13/2007 - "The high mortality rate of immunocompromised patients with fungal infections and the limited availability of highly efficacious and safe agents demand the development of new antifungal therapeutics. " 02/01/1994 - "The indications for therapy and the best treatment regimens for systemic fungal infections are not well defined. " 01/01/2023 - "In this review we summarize recent advances in the study of antifungal resistance, tolerance and persistence, with an emphasis on promising drug targets and drug delivery systems that may yield important insights into the development of new or improved antifungal therapies against fungal infections." 06/01/2014 - "Multicentre surveillance study on feasibility, safety and efficacy of antifungal combination therapy for proven or probable invasive fungal diseases in haematological patients: the SEIFEM real-life combo study."
2.	Drug Therapy (Chemotherapy) 11/01/2019 - "The increase in the number of fungal infections worldwide, coupled with the limitations of current antifungal chemotherapy, demand the development of safe and effective new antifungals. " 01/01/1982 - "The role of granulocyte transfusions, antifungal chemotherapy and the achievement of bone marrow remission in localization of the fungal disease is discussed." 01/01/1993 - "Recent development of immunodeficient transgenic mice will make these murine models even more valuable for studies on the diagnosis, pathogenesis, immunity, and chemotherapy of fungal infections." 01/01/1993 - "These murine models are also being used to study the histopathology and chemotherapy of a variety of fungal infections. " 10/01/2023 - "In recent decades, the incidence of fungal infections has increased dramatically, due in part to the increased number of transplants and the pervasive use of chemotherapy and immunosuppressive drugs. "
3.	Stem Cell Transplantation 11/01/2011 - "We investigated the efficacy of infection control measures on the frequency of fungal infection among hemato-oncologic patients undergoing stem cell transplantation during excavation and construction work of an adjacent hospital building. " 08/01/2017 - "The objective of the study was to determine the incidence of invasive fungal disease (IFD) in children undergoing autologous haematopoietic stem cell transplantation (auHSCT) for solid tumours (ST). " 03/26/2022 - "Invasive fungal disease (IFD) is a severe complication after haploidentical stem cell transplantation (haplo-HSCT) and has a poor prognosis. " 03/26/2022 - "Recipient and donor PTX3 rs2305619 polymorphisms increase the susceptibility to invasive fungal disease following haploidentical stem cell transplantation: a prospective study." 04/01/2021 - "Patients undergoing allogeneic stem cell transplantation (aSCT) are at high risk to develop an invasive fungal disease (IFD). "
4.	Transplantation 12/01/2020 - "Pre-transplantation relapse and invasive fungal disease after transplantation are the important factors affecting the efficacy of allo-HSCT in patients with AML-M5. " 04/01/2014 - "This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation." 10/01/2013 - "The aim of our study was to identify the incidence and characteristics of bacterial and fungal infections of adult small bowel or multivisceral (SB/MV) transplantation recipients in the 30-day postoperative period. " 07/01/2013 - "This study aimed to evaluate the significance of serum hepcidin-25 in predicting invasive fungal disease (IFD) after transplantation. " 12/01/2005 - "Multilayer amniotic membrane transplantation was performed after excluding of bacterial and fungal infection by microbiologic studies including smears and cultures of necrotic corneal tissue and confocal microscope. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/01/2011 - "The correct diagnosis of etiology of fungal infection after bone marrow transplantation is very important to the choice of antifungal drugs and a premise for improvement of therapeutic efficacy. " 09/01/1998 - "Similarly, ABCD was effective in patients with proven or suspected fungal infection after bone marrow transplantation. " 05/01/1996 - "Although allogeneic bone marrow transplantation from an HLA-matched unrelated donor was carried out in the non-remission stage, the patient died of systemic fungal infection on day 25, without any evidence of hematological engraftment. " 03/01/1994 - "A retrospective study was conducted to evaluate the efficacy of granulocyte transfusions in neutropenic patients with fungal infections following bone marrow transplantation. " 03/01/1994 - "Granulocyte transfusions: efficacy in treating fungal infections in neutropenic patients following bone marrow transplantation."