|1.||Daffé, Mamadou: 13 articles (12/2015 - 02/2006)|
|2.||Besra, Gurdyal S: 13 articles (06/2015 - 11/2003)|
|3.||Kremer, Laurent: 11 articles (08/2013 - 08/2005)|
|4.||Verschoor, Jan A: 8 articles (08/2015 - 09/2002)|
|5.||Minnikin, David E: 8 articles (06/2015 - 11/2003)|
|6.||Jacobs, William R: 7 articles (08/2013 - 06/2006)|
|7.||Jackson, Mary: 6 articles (01/2014 - 12/2003)|
|8.||Laval, Françoise: 5 articles (12/2015 - 02/2007)|
|9.||Eynard, Nathalie: 4 articles (01/2015 - 02/2007)|
|10.||Baird, Mark S: 4 articles (07/2013 - 12/2003)|
01/01/2013 - "In summary, this study uncovered new mutations associated with TAC resistance and also demonstrated that simple structural optimization of the TAC scaffold was possible and may lead to a new generation of TAC-derived drug candidates for the potential treatment of tuberculosis as mycolic acid inhibitors."
08/10/2015 - "Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis."
01/01/2015 - "Gram positive mycobacteria with a high GC content, such as the etiological agent of tuberculosis Mycobacterium tuberculosis, possess an outer membrane mainly composed of mycolic acids (MAs), the so-called mycomembrane, which is essential for the cell. "
01/01/2015 - "Fatty acid degradation protein D32 (FadD32), an enzyme required for mycolic acid biosynthesis and essential for mycobacterial growth, has recently been identified as a valid and promising target for anti-tuberculosis drug development. "
01/01/2014 - "Mycolic acids are the major lipid components of the unique mycobacterial cell wall responsible for the protection of the tuberculosis bacilli from many outside threats. "
|2.||Leprosy (Hansen's Disease)
04/07/2015 - "All samples were differentiated using a lipidomics-based data workup employing multivariate data analysis, which helped electing different lipid markers, for example, mycobacterial mycolic acids, inflammatory and apoptotic molecules were identified as leprosy patients' markers. "
06/15/1982 - "In the present work, mycolic acids from leprosy-derived and reference corynebacteria have been fractionated by monodimensional and bidimensional thin-layer chromatography and by gas chromatography. "
12/01/1981 - "Mycolic acids with the same structure were also obtained from mycobacteria collected from the liver of an armadillo with experimental leprosy. "
11/01/1980 - "Separation of mycolic acid classes according to their functional groups by thin-layer chromatography showed a difference between Mycobacterium leprae and a number of strains of acid-fast bacilli cultured from leprosy biopsies in vitro. "
09/01/1979 - "Although the presence of mycolic acid in tissues is not, in itself, diagnostic for leprosy, its demonstration in biopsy tissues might be a useful additional qualitative test if used in conjunction with clinical evidence of the disease."
01/01/2014 - "It is proved that the relationship between different types of mycolic acids, their length and the degree of cyclopropanation may vary depending on the stage of infection and mycobacterial culture conditions. "
06/01/2011 - "Here, we characterized T cells specific for mycolic acid (MA), the predominant mycobacterial cell wall lipid and key virulence factor, in patients with active TB infection. "
04/01/2008 - "Between March and May 2006, a Texas hospital identified five Mycobacterium mucogenicum bloodstream infections among hospitalized oncology patients using fluorescence high-performance liquid chromatography analysis of mycolic acids. "
12/19/2005 - "However, endogenous receptors for mycolic acids on susceptible cells exposed to mycobacterial infections have not been fully identified. "
01/01/2005 - "In view of the fact that the same treatment regimen is recommended for infections caused by these two species, TLC mycolic acid analysis may be a useful identification tool wherever molecular methods are unaffordable."
06/16/1964 - "[STUDY OF THE HYPERSENSITIVITY REACTION DETECTED IN ORGANISMS ALLERGIC TO THE KOCH BACILLUS BY POLYSACCHARIDE ESTERS OF MYCOLIC ACID EXTRACTED FROM TUBERCLE BACILLI (PMKO AND CIRES D)]."
11/01/1965 - "[Immunological studies on the specific intradermal reactions of hypersensitivity induced by the polysaccharide esters of mycolic acid in subjects hypersensitive to tuberculin]."
07/01/2014 - "Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair."
03/01/1997 - "We therefore discussed the relationship between the chemical structure and granuloma-forming activity of TDM, especially in relation to the structure of mycolic acid in TDM."
09/21/1964 - "[CYTOMORPHOLOGICAL-HISTOCHEMICAL AND AUTORADIOGRAPHIC FINDINGS IN MYCOLIC ACID GRANULOMA IN GUINEA PIGS]."
12/21/2014 - "The granuloma is treated with isoniazid (INH), a drug that inhibits the synthesis of mycolic acids (MA). "
03/01/1997 - "Granuloma formation activity and mycolic acid composition of mycobacterial cord factor."
|2.||Biological Markers (Surrogate Marker)
|10.||Interferon-gamma (Interferon, gamma)