|1.||Hypertension (High Blood Pressure)
01/01/1985 - "Efficacy of two different doses of muzolimine in the treatment of mild hypertension."
07/01/1990 - "Muzolimine is a diuretic which has been proposed in the treatment of hypertension. "
07/01/1986 - "The antihypertensive effects and haemodynamic changes after administration of 30 mg/die of muzolimine for 30 days in a group of patients with mild or moderate essential hypertension have been evaluated. "
07/01/1986 - "[Clinical and hemodynamic effects of medium-term treatment with muzolimine in subjects with essential arterial hypertension]."
01/01/1985 - "A report is given on the effects of oral therapy with muzolimine (M) in patients with mild hypertension. "
01/01/1985 - "To summarize, it can be stated that patients with chronic heart failure (NYHA 2 and 3) can be effectively treated by muzolimine monotherapy."
01/01/1985 - "The aim of the present study was to investigate muzolimine pharmacokinetics and pharmacodynamics in chronic heart failure. "
01/01/1985 - "A multi-center open trial was carried out with 103 patients with chronic congestive heart failure (CHF) of diverse etiologies with oedemas, 25 with hepatomegalia, placed in classes II or III of NYHA functional capacity, with increasing doses of 30, 60 and 90 mg of muzolimine qd to ascertain (1) the effective dose for the elimination of oedemas and hepatomegalia and (2) whether such a dose keeps its efficacy throughout a long administration period. "
01/01/1985 - "Pharmacokinetics and pharmacodynamics of muzolimine in chronic heart failure."
01/01/1985 - "Muzolimine as monotherapy in the treatment of patients with congestive cardiac failure."
|3.||Renal Insufficiency (Renal Failure)
01/01/1977 - "Clearance studies were carried out in 18 non-oedematous patients with advanced renal failure (glomerular filtration rate less than 12 ml/min) to assess the diuretic effects of Bay g 2821 given different oral doses (120 mg to 360 mg). "
03/01/1990 - "[Neuromyeloencephalopathy caused by high-dose muzolimine medication in patients with renal failure]."
05/20/1988 - "[Circadian rhythm in Na+ and K+ excretion during a change in muzolimine dosage and administration intervals in renal insufficiency]."
01/01/1985 - "Pharmacokinetics and clinical effects of muzolimine were investigated in 6 hypertensive patients with incipient renal insufficiency. "
01/01/1985 - "Pharmacokinetics of muzolimine after acute and chronic dosing in hypertensive patients with mild renal insufficiency."
|4.||Chronic Kidney Failure (Chronic Renal Failure)
01/01/1985 - "Muzolimine in chronic renal failure: a study in 16 patients."
01/01/1991 - "We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy. "
03/01/1990 - "We report on 7 patients suffering from chronic renal failure (2 females, 5 males; aged 35-75 (phi 53.5) years) who showed severe neuromyeloencephalopathy (NME) after high doses of a new Henle's loop diuretic, Muzolimine. "
01/01/1985 - "Muzolimine (240 mg) was administered orally to 24 patients with chronic renal failure. "
01/01/1985 - "Diuretic effect and pharmacokinetic data observed at different stages of chronic renal failure with 240 mg of muzolimine."
|5.||Acute Kidney Injury (Acute Renal Failure)
01/01/1985 - "The aim of this study was to test the efficiency of muzolimine in patients with acute renal failure (ARF). "
01/01/1985 - "Clinical study of muzolimine in acute renal failure, pharmacodynamics and pharmacokinetics."
01/01/1985 - "Furthermore, they strongly implicate muzolimine as the diuretic of choice in acute renal failure."
01/01/1985 - "Beneficial effect of muzolimine in postischemic acute renal failure in rats."
01/01/1985 - "for the therapy of acute renal failure, muzolimine treatment by food or implanted osmotic minipumps was employed in an obstructive model of severe renal ischemia in rats. "
|3.||Clonidine (ST 155)
|5.||Antihypertensive Agents (Antihypertensives)