|1.||Sinha, Rashmi: 24 articles (10/2015 - 09/2002)|
|2.||Cross, Amanda J: 12 articles (07/2012 - 01/2004)|
|3.||Widmann, Christian: 7 articles (04/2014 - 11/2004)|
|4.||Sinha, R: 5 articles (08/2013 - 05/2001)|
|5.||Fenech, Michael: 5 articles (01/2011 - 06/2003)|
|6.||Schatzkin, Arthur: 5 articles (11/2009 - 12/2007)|
|7.||Wu, Kana: 4 articles (10/2015 - 06/2006)|
|8.||Dianov, Grigory L: 4 articles (04/2015 - 01/2011)|
|9.||Cross, A J: 4 articles (08/2013 - 07/2009)|
|10.||Graubard, Barry I: 4 articles (07/2012 - 05/2009)|
04/01/2014 - "To increase the efficacy of currently used anti-cancer genotoxins, one of the current efforts is to find agents that can sensitize cancer cells to genotoxins so that the efficacious doses of genotoxins can be lowered to reduce deleterious side-effects. "
09/01/2011 - "To increase the efficacy of currently used anti-cancer genotoxins, a combination use of different drugs is a potential new therapeutical tool. "
07/01/2008 - "We also discuss the importance of an epigenetic cross-talk in the protection against genetic changes in response to environmental genotoxins as well as the implication for cancer therapy and prevention."
01/01/2003 - "The yeast assay could hold promise for the identification of mutagens implicated in human cancer if the p53 mutational spectra obtained with this assay would match human tumor mutation data. "
04/01/2015 - "PT/Y mice used for studies of the effects of mutagens are characterized by the absence of spontaneous tumors of the liver, but often develop these tumors in response to chronic oaminoazotoluene treatment. "
|2.||Chromosome Aberrations (Chromosome Abnormalities)
05/01/2001 - "Chromosome aberration assays in Pisum for the study of environmental mutagens."
06/01/1998 - "Chromosome aberration assays in Crepis for the study of environmental mutagens."
03/01/1998 - "The study comprised 100 subjects, all medical staff occupationally exposed to X-rays, who were re-examined for unstable chromosomal aberrations after 3 months (12 subjects), 6 months (31 subjects), 9 months (13 subjects), 12 months (21 subjects), over 24 months (14 subjects), and over 36 months (9 subjects) controls were 60 subjects who were not exposed to ionizing radiation or chemical mutagens at their workplaces. "
07/25/1981 - "Prevalence of chromosome abnormalities during human gestation and implications for studies of environmental mutagens."
02/01/2013 - "The investigation revealed that none of the three materials were able to produce marked human lymphocyte chromosomal aberration, suggesting the absence of mutagens. "
07/14/2006 - "Mouse lymphoma L5178Ytk+/- (MOLY) cells and human lymphoblastoid TK6 and WTK-1 cells are widely used to detect mutagens in vitro. "
01/01/2002 - "The mouse lymphoma assay (MLA) utilizing the Tk gene is widely used to identify chemical mutagens. "
07/31/1998 - "We evaluated the relationship between the onset of DNA damage and the characteristics of 5 model chemical mutagens with the single-cell gel electrophoresis (SCG) assay using L5178Y mouse lymphoma cells. "
09/18/1997 - "We evaluated the relationship between the onset of DNA damage and the characteristics of 5 model chemical mutagens with the single-cell gel electrophoresis (SCG) assay using L5178Y mouse lymphoma cells. "
09/01/1995 - "Some regulatory agencies accept data from the mouse lymphoma mutation assay to detect clastogens if the protocol is optimized for the detection of small colonies or if colony sizing data are submitted. "
|4.||Breast Neoplasms (Breast Cancer)
01/01/2002 - "Fluid obtained by ductal lavage may allow for more detailed studies of the role of mutagens in breast cancer."
06/01/2013 - "Pol λ interacted directly with XRCC4 and Lig4 via its N-terminal breast cancer-associated C terminus (BRCT) domain in a yeast two-hybrid system, while increased sensitivity of BRCT-deficient Pol λ-expressing transgenic atpolλ-2 mutants toward genotoxins indicated the importance of the BRCT domain of AtPolλ in mediating the interactions for processing DSBs. "
01/01/2011 - "To examine whether smoking during first pregnancy, a time of potential vulnerability to tobacco mutagens, is associated with breast cancer. "
05/01/2010 - "Higher consumption of mutagens from meats cooked at higher temperature and longer duration was not associated with increased risk of postmenopausal breast cancer. "
05/01/2010 - "Meat mutagens and breast cancer in postmenopausal women--a cohort analysis."
|5.||Genetic Predisposition to Disease (Genetic Predisposition)
04/01/2001 - "The sensitivity and specificity of the CA assay are improved with the use of the fluorescence in situ hybridization (FISH) procedure, which employs a variety of chromosome-specific and chromosome region-specific fluorescence probes to elucidate CA. Factors that influence the expression of CA in a population study include inadequate study design, genetic variations in metabolism of chemicals (genetic susceptibility), and lifestyle differences in response to exposure to environmental mutagens (acquired susceptibility). "
09/20/2000 - "Although many factors can contribute to variability in human biomonitoring studies, genetic susceptibility (the influence of polymorphic metabolising genes on response to environmental mutagens) should be considered whenever appropriate. "
01/01/2015 - "environmental mutagens, genetic predisposition. "
04/01/1986 - "This variability may be viewed as subtle inherent genetic predisposition of sensitivity to mutagens that could be evaluated only using sensitive measures (e.g., SCE and not micronuclei) following more than one mutagenic challenges. "
02/01/1983 - "These findings imply that lymphoblastoid lines may not always be the appropriate cell type for investigating genetic susceptibility to chemical mutagens."
|2.||DNA (Deoxyribonucleic Acid)
|8.||Butyric Acid (Butanoic Acid)
|10.||Glutathione (Reduced Glutathione)
|1.||Drug Therapy (Chemotherapy)