Spinal Muscular Atrophy (Progressive Muscular Atrophy)

A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
Also Known As:
Progressive Muscular Atrophy; Adult Spinal Muscular Atrophy; Distal Spinal Muscular Atrophy; Spinal Muscular Atrophy, Distal; Muscular Atrophy, Spinal; Adult-Onset Spinal Muscular Atrophy; Muscular Atrophy, Adult Spinal; Myelopathic Muscular Atrophy; Myelopathic Muscular Atrophy, Progressive; Progressive Myelopathic Muscular Atrophy; Progressive Proximal Myelopathic Muscular Atrophy; Proximal Myelopathic Muscular Atrophy, Progressive; Spinal Muscular Atrophy, Oculopharyngeal; Spinal Muscular Atrophy, Scapuloperoneal Form; Adult Onset Spinal Muscular Atrophy; Atrophies, Progressive Muscular; Atrophy, Myelopathic Muscular; Atrophy, Progressive Muscular; Atrophy, Spinal Muscular; Bulbospinal Neuronopathies; Muscular Atrophies, Progressive; Muscular Atrophy, Myelopathic; Muscular Atrophy, Progressive; Neuronopathies, Bulbospinal; Neuronopathy, Bulbospinal; Progressive Muscular Atrophies; Bulbospinal Neuronopathy; Oculopharyngeal Spinal Muscular Atrophy; Scapuloperoneal Form of Spinal Muscular Atrophy
Networked: 757 relevant articles (19 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Disease Progression
2. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
3. Huntington Disease (Huntington's Disease)
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Muscular Dystrophies (Muscular Dystrophy)


1. Wirth, Brunhilde: 18 articles (01/2015 - 03/2006)
2. Swoboda, Kathryn J: 14 articles (12/2015 - 05/2005)
3. Corti, Stefania: 9 articles (09/2015 - 01/2006)
4. Sumner, Charlotte J: 9 articles (04/2015 - 11/2003)
5. Jablonka, Sibylle: 9 articles (05/2014 - 01/2002)
6. Crawford, Thomas O: 8 articles (04/2015 - 08/2007)
7. Riessland, Markus: 8 articles (01/2015 - 07/2006)
8. Prior, Thomas W: 8 articles (02/2014 - 05/2005)
9. Bassell, Gary J: 8 articles (06/2012 - 10/2004)
10. Rossoll, Wilfried: 8 articles (06/2012 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spinal Muscular Atrophy:
1. Histone Deacetylase InhibitorsIBA
2. Thyrotropin-Releasing Hormone (Protirelin)FDA Link
3. Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
4. gabapentin (Neurontin)FDA LinkGeneric
5. Antisense OligonucleotidesIBA
6. Hydroxyurea (Hydrea)FDA LinkGeneric
7. Oxyhemoglobins (Oxyhemoglobin)IBA
8. Insulin (Novolin)FDA Link
9. RNA Precursors (Precursor, mRNA)IBA
10. plastinIBA

Therapies and Procedures

1. Walkers
2. Intravenous Injections
3. Oral Administration
4. Mechanical Ventilators (Ventilator)
5. Therapeutics