|1.||Wounds and Injuries (Trauma)
|2.||Critical Illness (Critically Ill)
|5.||Open Fractures (Compound Fracture)
|1.||Hildebrand, Frank: 15 articles (06/2014 - 07/2003)|
|2.||Krettek, Christian: 12 articles (07/2015 - 07/2003)|
|3.||Frink, Michael: 9 articles (04/2013 - 01/2005)|
|4.||van Griensven, Martijn: 8 articles (06/2014 - 01/2005)|
|5.||Bouillon, Bertil: 8 articles (04/2014 - 05/2002)|
|6.||Mutschler, W: 8 articles (01/2014 - 02/2000)|
|7.||Brown, Rex O: 8 articles (07/2010 - 05/2004)|
|8.||Minard, Gayle: 8 articles (07/2010 - 05/2004)|
|9.||Dickerson, Roland N: 8 articles (07/2010 - 05/2004)|
|10.||Pape, Hans-Christoph: 7 articles (06/2014 - 01/2005)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
06/01/2015 - "All patients were treated with multiple wound debridements, graft salvage, sartorius myoplasty, intravenous antibiotics and VAC therapy until thorough surface healing was achieved. "
09/26/1990 - "[Trauma surgery in the USA (II): Restricted use of antibiotics in septic reaction after multiple trauma]."
09/01/1987 - "In each patient there was at least one characteristic prodromal condition, including trauma, multiple antibiotics following bowel surgery, and acute nonlymphocytic leukemia. "
04/01/1987 - "The effect of oropharyngeal decontamination using topical nonabsorbable antibiotics on the incidence of nosocomial respiratory tract infections in multiple trauma patients."
02/01/2004 - "Prophylactic administration of antibiotics is prevalent for traumatic patients including head injury, when the patients have contaminated wounds, CSF leakage, and multiple injuries. "
|2.||Heparin (Liquaemin)FDA LinkGeneric
09/01/1982 - "The use of a heparin-bonded shunt maintained cerebral perfusion, and greatly simplified the operation and avoided the risk of extracorporeal circulation and systemic anticoagulation in a patient with multiple trauma."
08/01/2006 - "Multiple-trauma patients are at increased risk for DVT but are also at increased risk of bleeding, and the use of heparin may be contraindicated. "
08/01/2002 - "To demonstrate a clinical decision-making process by which to determine if heparin prophylaxis for deep venous thrombosis (DVT) is appropriate in a specific patient with multiple injuries. "
08/01/2002 - "Heparin prophylaxis for deep venous thrombosis in a patient with multiple injuries: an evidence-based approach to a clinical problem."
06/01/2000 - "This case presentation details a multiple trauma patient in whom heparin-induced thrombocytopenia developed and the effect this syndrome had on her treatment and eventual recovery."
|3.||Lactic AcidFDA LinkGeneric
01/01/2007 - "The aim of this study was to assess the effect of early optimization of intravascular volume using esophageal Doppler on blood lactate levels and organ dysfunction development in comparison with standard hemodynamic management in multiple-trauma patients. "
02/01/2001 - "This prospective, multi-center, observational study of 2069 multiple trauma patients evaluated the prognostic significance of the posttrauma base deficit (BD) on hospital and intensive care unit (ICU) admission to hemodynamic changes, volume and transfusion requirements, lactate and coagulation, as well as mortality. "
09/01/2015 - "There is no correlation between admission lactate or lactate clearance and mortality in patients treated with multiple trauma."
02/01/2012 - "The lactic acid results in the first 24 hours of the multiple injury patient are associated with mortality and MOF, even when the patient is haemodynamically stable."
02/01/2012 - "[Measurement of lactic acid in multiple injury patients and its usefulness as a predictor of multiorgan failure and mortality]."
05/01/2001 - "During nutrition support, serum phosphorus concentrations are lower in thermally injured patients compared with multiple trauma patients despite receiving a significantly greater intake of phosphorus. "
05/01/2001 - "Average total daily phosphorus intake during the 14-day study for thermally injured patients and multiple trauma patients was 0.99+/-0.26 mmol/kg/d vs 0.58+/-0.21 mmol/kg/d, respectively, p < .001. "
05/01/2001 - "Urinary phosphorus clearance, fractional excretion of phosphorus, or renal threshold phosphate concentrations were also not significantly different between thermally injured and multiple trauma patients. "
05/01/2001 - "Differences in urinary phosphorus excretion was not statistically significant between the thermally injured and multiple trauma groups (271+/-213 mg/d vs 171+/-181 mg/d for week 1, and 320+/-289 mg/d vs 258+/-184 mg/d for week 2, respectively). "
05/01/2001 - "Serum phosphorus concentration on the third day of observation was significantly lower in the thermally injured group than those with multiple trauma (1.9+/-0.8 mg/dL vs 3.0+/-0.8 mg/dL, p < or = .01). "
|5.||Amino AcidsFDA Link
10/01/1994 - "Influence of diet with or without amino acids on polyamine excretion in multiple trauma victims."
05/01/1989 - "Multiple injury provoked distinct patterns of free amino acids in plasma and urine. "
09/01/1985 - "The body clearance of 10 plasma amino acids (AA) was determined from the rate of compared muscle-released AA and AA administered by infusion of total parenteral nutrition (TPN) compared to their estimated extracellular (ECW) pool in patients with multiple trauma with (n = 10) or without (n = 16) sepsis at 8-hour intervals. "
02/01/1991 - "The recommended ratio of amino acids with branched carbon chains for patients with multiple injuries (i. e. "
10/01/1981 - "[Behavior of free amino acids in plasma and urine of intensive care patients with multiple injuries during the administration of an amino acid solution with 10% branched-chain amino acids]."
08/01/2013 - "Steroids are effective in reducing the incidence of PE in multiple trauma patients. "
01/01/2015 - "In our study, we aimed to evaluate whether low-dose steroids prevent VAP onset in multiple trauma patients. "
08/01/2013 - "We aimed to evaluate whether early low-dose steroids prevent symptomatic PE onset in multiple trauma patients. "
01/01/1986 - "Patients with multiple injuries or infections, or those who received steroids, were excluded. "
10/01/1989 - "These relationships were not significantly altered when confounding variables such as the amount of glucose given over the initial 24-hour postinjury period, the presence of diabetes or multiple injuries, and whether patients were given steroids, dilantin, or insulin were statistically incorporated. "
06/20/1987 - "[Evaluation of the clearance of creatinine in patients with multiple injuries]."
01/01/1990 - "Plasma creatinine is not a useful indicator in multiple trauma. "
01/01/1990 - "Higher levels of both plasma and urinary creatinine were observed in the multiple trauma patients with all the methods used. "
01/01/1990 - "The correlation between creatinine clearance and inulin clearance is not very strong in multiple trauma, indicating that the relative evolution (not the absolute values) of creatinine clearance is of interest."
01/01/1990 - "The best correlations between inulin clearance and creatinine clearance were observed for Jaffé's rapid kinetics (r = 0.90) in the control group and for the enzymatic procedure in the multiple trauma group (r = 0.55). "
|8.||Ethanol (Ethyl Alcohol)IBA
05/01/2011 - "Knowledge of the influence of ethanol in a multiple trauma cohort is lacking. "
03/01/2014 - "Among older trauma patients, this study shows significant associations with multiple trauma outcomes, including one between elevated ethanol concentrations and improved outcomes. "
07/01/2000 - "Autopsy of the auto driver revealed multiple injuries with exsanguination, and only vitreous humor and liver tissue, but not blood, were tested for ethyl alcohol. "
|9.||Prostaglandins F (PGF)IBA
|10.||Fibrinogen (Factor I)FDA Link
10/01/2009 - "After severe multiple trauma a fibrinogen deficit develops and must be adequately compensated. "
04/01/2005 - "In the 30 and 60-day multiple injuries groups, a statistically significant fibrinogen increase was observed (336.6 +/- 7.5 and 358.7 +/- 9.9, respectively) compared with the control group (207.0 +/- 3.0) (p < 0.001). "
09/01/2002 - "A statistically significant increment of fibrinogen was observed when comparing uninjured animals (control) (208.7+/-6.0) with the multiple injury group (336.6+/-7.5) (P<0.001). "
08/01/2010 - "In multiple trauma patients, priority must be given to early and effective correction of impaired fibrin polymerization by administering fibrinogen concentrate."
03/01/2001 - "A low GOS was significantly and independently associated with a low GCS, multiple trauma, delayed aPTT, low fibrinogen level, elevated FDP and low platelet count. "
02/01/1996 - "Beyond the year 2000, resuscitation research might become more challenging and cost-effective in the area of multiple trauma, which concerns the young and fit. "
11/01/2010 - "The present study allowed to conclude that "low infusion resuscitation" technique in patients with multiple trauma accompanied by acute massive blood loss of extremely severe degree enables to reduce lethality, to achieve early subcompesatory hemodynamic state in acute traumatic disease."
08/01/2004 - "This study aimed to determine whether nonsurgical management using transcatheter arterial embolization (TAE) is safe for patients with blunt multiple trauma who transiently respond to the initial fluid resuscitation. "
05/01/2015 - "To discuss the clinical effects of damage control resuscitation (DCR) in treating severe multiple trauma in the pelvic fractures. "
05/01/2015 - "[Damage control resuscitation of severe multiple trauma in the pelvic fractures]."
10/01/2010 - "Multiple injury patients were mainly treated by operation, including debridement and suturation, closed reduction and external fixation, etc."
10/01/2010 - "Debridement and suturation for single injury and multiple injury patients accounted for 64.7% and 42.9% of their operations respectively. "
03/01/2010 - "Acute vascular reconstruction and multiple wound debridements throughout the evacuation chain set the stage for successful rigid fixation. "
04/01/2007 - "Multiple wound debridements were required in nearly half of the patients. "
07/01/2012 - "He underwent multiple wound debridements, which included a total penectomy and right orchiectomy. "
01/01/2015 - "The patients in our series had multiple injuries and the device allowed early mobilization and produced good results. "
07/01/2004 - "The results we obtained suggest that DFN represents a valid alternative to the open treatment of fractures of the distal metaphysis of the femur; in cases of patients with multiple trauma or in elderly patients where invasiveness is reduced, importance is awarded to less blood loss, a shorter amount of time required for surgery, and early mobilization and weight-bearing."
06/01/1986 - "A 26-year-old male with multiple injuries including such fractures was successfully treated with a variety of internal fixation techniques, allowing early mobilization. "
10/01/1998 - "[How many severely injured multiple-trauma patients can benefit from the biomechanical advantage of early mobilization following femoral intramedullary nailing?]."
07/01/1980 - "The authors feel that early definitive fracture care employing rigid fixation which avoids casts, and allows improved wound management and early mobilization of the multiple-trauma patient, has decreased the cardiopulmonary and metabolic consequences commonly associated with polytrauma patient care."
|4.||Enteral Nutrition (Feeding, Tube)
01/01/2011 - "Thirty-two patients with multiple trauma who had been admitted to the general ICU of Changzheng Hospital, Shanghai, from March 2007 to May 2008, were randomly divided into two groups: an enteral immunonutrition group (EIN group, n=16) and an enteral nutrition group (EN group, n=16). "
06/01/2003 - "Even though enteral nutrition is the preferred method of feeding, it is not always feasible after multiple trauma. "
12/01/1999 - "Early enteral feeding of patients with multiple trauma."
03/01/1992 - "[Enteral nutrition in the multiple trauma patient]."
06/01/1986 - "[Combined parenteral and enteral nutrition in multiple injuries]."
|5.||Length of Stay
06/01/1993 - "Although he had a prolonged length of stay and several complications, he survived multiple injuries and had a positive outcome. "
01/01/2013 - "Some groups of patients with multiple injuries had a longer length of stay."
01/01/2013 - "The separate analysis per each level of lesion/AIS grade showed that in some groups, patients with multiple injuries had a significant longer length of stay or worse functional status at rehabilitation admission (but not at discharge) than their monotraumatic counterparts. "
12/01/2006 - "The average length of stay (LOS) of children with an isolated fracture, was 10 days, and in case of multiple injuries: 12 days. "
12/01/2005 - "We analyzed the relationship between functional outcome and sociodemographic (age and gender) and injury-related determinants (type of injury, external cause, multiple injury, admission to hospital, and length of stay) by logistic regression analysis. "