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Multiple Sclerosis

An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Also Known As:
Disseminated Sclerosis; Sclerosis, Multiple; MS (Multiple Sclerosis); Multiple Sclerosis, Acute Fulminating; Sclerosis, Disseminated
Networked: 18452 relevant articles (932 outcomes, 2499 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
2. Autoimmune Diseases (Autoimmune Disease)
3. Rheumatoid Arthritis
4. Demyelinating Diseases (Demyelinating Disease)
5. Pain (Aches)

Experts

1. Hartung, Hans-Peter: 111 articles (12/2015 - 12/2002)
2. Kappos, Ludwig: 90 articles (12/2015 - 01/2003)
3. Montalban, Xavier: 83 articles (12/2015 - 02/2002)
4. Gold, Ralf: 80 articles (12/2015 - 03/2002)
5. Giovannoni, Gavin: 78 articles (11/2015 - 10/2002)
6. Comi, Giancarlo: 70 articles (12/2015 - 04/2003)
7. Kieseier, Bernd C: 68 articles (10/2015 - 04/2003)
8. Olsson, Tomas: 67 articles (12/2015 - 03/2002)
9. Steinman, Lawrence: 62 articles (09/2015 - 04/2002)
10. Polman, Chris H: 60 articles (10/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Sclerosis:
1. natalizumab (Tysabri)FDA Link
2. Interferon-betaIBA
3. fingolimod (FTY720)FDA Link
4. copolymer 1 (glatiramer acetate)FDA Link
5. InterferonsIBA
6. MethylprednisoloneFDA LinkGeneric
7. interferon beta 1aFDA Link
8. AntibodiesIBA
9. Mitoxantrone (Novantrone)FDA LinkGeneric
10. CannabinoidsIBA

Therapies and Procedures

1. Injections
2. Immunotherapy
3. Transplantation (Transplant Recipients)
4. Immunomodulation
5. Drug Therapy (Chemotherapy)