Multiple Organ Failure (MODS)

A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Also Known As:

MODS; Multiple Organ Dysfunction Syndrome; Failure, Multiple Organ; Multiple Organ Failures; Organ Dysfunction Syndrome, Multiple; Organ Failure, Multiple

Networked: 4314 relevant articles (204 outcomes, 357 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Shock: 42082
    - Multiple Organ Failure: 4314

Related Diseases

1.	Sepsis (Septicemia)
2.	Multiple Organ Failure (MODS)
3.	Septic Shock (Toxic Shock Syndrome)
4.	Wounds and Injuries (Trauma)
5.	Infections

Experts

1.	Moore, Ernest E: 26 articles (11/2022 - 11/2002)
2.	Gando, Satoshi: 22 articles (01/2022 - 08/2002)
3.	Gilman, Robert H: 22 articles (01/2022 - 10/2004)
4.	Carcillo, Joseph A: 20 articles (01/2022 - 02/2002)
5.	Cuzzocrea, Salvatore: 20 articles (09/2011 - 10/2002)
6.	Thiemermann, Christoph: 19 articles (07/2022 - 01/2002)
7.	Moore, David A J: 16 articles (01/2022 - 10/2004)
8.	Lefering, Rolf: 15 articles (12/2021 - 04/2002)
9.	Mazzon, Emanuela: 15 articles (09/2011 - 10/2002)
10.	Werdan, Karl: 14 articles (03/2022 - 04/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Organ Failure:

1.	CytokinesIBA 01/01/2007 - "Our data indicate that CPFA combined with CVVH is an effective and safe method to improve the prognosis of MODS patients with ALF, the mechanism of which may be related to its effective removal of inflammatory cytokines." 05/01/2016 - "The aim of the present study was to evaluate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in patients with MODS and to determine the association between Treg cells and serum cytokine levels. " 02/21/2003 - "In the present study, we investigated plasma levels of pro- and anti-inflammatory cytokines in survivors and non-survivors from MODS in the early postoperative course following open heart surgery. " 07/01/1996 - "Further studies are needed to elucidate what happens with these cytokines at the tissue level, to better understand the pathophysiology of multiple organ dysfunction syndrome." 01/01/2021 - "Into the systemic circulation, cytokines in excess might leak out of pulmonary circulation, causing systemic symptoms and possibly a multiple-organ dysfunction syndrome. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 10/17/2022 - "After several weeks with multiple organ dysfunction syndrome, he responded favorably to antibiotic treatment. " 01/01/2023 - "The incidences of MODS, admission to ICU, ventilation, and broad-spectrum antibiotic treatment were significantly higher in the IPA group than in the non-IPA group. " 01/01/2019 - "The story explores the thoughts of an elderly patient, who is hospitalized because of multiple organ failure, as she contemplates the voluntary refusal of food, fluid, and antibiotics. " 09/05/2017 - "MODS can rapidly confirm probable MDR-TB detected by GeneXpert-MTB/RIF, manual-MGIT can provide early results for susceptibility to other antibiotics, with affordable costs, with LJ-DST confirming discordant DSTs." 01/01/2017 - "Despite adequate antibiotic treatment, the patient died from septic multiple organ failure. "
3.	ZymosanIBA 06/01/2002 - "In conclusion, TNF-deficient mice exhibit significantly improved morbidity and mortality during zymosan-induced MODS. " 06/01/2002 - "Improved survival of TNF-deficient mice during the zymosan-induced multiple organ dysfunction syndrome." 07/01/2011 - "The aim of this study was to investigate the effect of HBO exposure on TLR2 and TLR4 signal transduction and organ dysfunction during MODS induced by zymosan in the rat. " 01/01/2015 - "At late stage of MODS mice induced by zymosan, the expression of co-stimulators and inhibitors in spleen DCs was imbalanced to form tolerant DCs which reduced the activation of T-cells. " 01/01/2015 - "Tolerant DC and MODS were induced by intraperotineal injection of zymosan. "
4.	Interleukin-6 (Interleukin 6)IBA 01/01/2017 - "Combined monitoring of PCT and IL-6 values and their dynamic changes is helpful for detecting the incidence of early ARDS in patients with MODS, and the index can predict whether ARDS will occur. " 10/01/2022 - "The number of organ dysfunction and interleukin-6 at CRRT initiation are independent risk factors for death in pediatric patients with SHLH-associated MODS." 09/01/2018 - "The ISS, APACHE II score, NF-κB, IL-6 and TNF-α levels in the MODS group at admission and 24 and 48 h after admission were higher than those in the non-MODS group (P<0.05). " 01/01/2017 - "The combined assessment of PCT and IL-6 can predict the prognosis of ARDS patients with MODS." 01/01/2017 - "The serum PCT and IL-6 levels were significant for the diagnosis of ARDS patients with MODS, and the serum levels of PCT and IL-6 were associated with the severity of MODS with ARDS. "
5.	Oxygen (Dioxygen)IBA 04/01/2011 - "This study compared the parameter estimates of pulmonary oxygen uptake (VO(2p)), heart rate (HR) and muscle deoxygenation (Δ[HHb]) kinetics when several moderate-intensity exercise transitions (MODs) were performed during a single visit versus several MODs performed during separate visits. " 10/01/2022 - "This paper is the first known documentation of a covid patient in ARDS and MODS who recovered from home through Ayurveda telemedicine and when not completely dependent on oxygen. " 01/28/2022 - "Meta-analyses indicated that the blood oxygen partial pressure [mean difference (MD) = 5.75, 95% confidence interval (CI) (3.80, 7.70)], blood oxygen saturation [MD = 6.43, 95% CI (4.39, 8.48)], oxygenation index [MD = 26.75, 95% CI (14.61, 38.89)] of experimental group was significantly higher than that of control group (all P < .001), the incidence of multiple organ failure [odds ratio = 0.42, 95% CI (0.31, 0.56), P < .001], mortality on day 28 [odds ratio = 0.44, 95% CI (0.33, 0.59)] of experimental group was significantly less than that of control group (all P < .001). " 01/01/2018 - "Cardiac dysfunction is a well-recognized important component of septic multiple organ failure and can compromise the balance between oxygen supply and demand, ultimately leading to the development of multiple organ failure. " 10/01/2011 - "The physiological and biochemical abnormalities that constitute multiple organ failure represent cellular perturbations that, importantly, need to be reconciled with a lack of significant cell death together with availability but impaired utilization of oxygen. "
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/01/2015 - "[Modulation of endothelial progenitor cells by tumor necrosis factor-α in multiple organ dysfunction syndrome in swine]." 09/01/2009 - "Phosphorylation of p38MAPK was obviously increased in extent, which enhanced gene expression of TNF-alpha and then secretion of TNF-alpha by the peripheral blood mononuclear cell in MODS, and the differences were statistically significant compared with that of control group (P<0.05 or P<0.01). " 07/01/2008 - "Under the normal physiologic condition, TNF-alpha and NO moved steadily without chaotic properties; while under the pathologic condition of MODS, they manifest relatively complicated chaotic properties. " 11/01/2006 - "The serum levels of sFas, sFasL and TNF-alpha in patients with MODS were significantly higher than those in controls (P<0.05 or P<0.01), and were associated with severity of the disease (all P<0.01) . " 11/01/2006 - "The correlations between sFas, sFasL and TNF-alpha levels and severity of MODS and the correlations between the TNF-alpha levels and the levels of sFas and sFasL were also observed. "
7.	Indicators and Reagents (Reagents)IBA 01/01/2015 - "In the operational setting of Chiang Rai, Thailand, we compared the performance of Auto-MODS with the gold standard liquid culture method in Thailand, mycobacterial growth indicator tube (MGIT) 960 plus the SD Bioline TB Ag MPT64 test, in terms of accuracy and efficiency in differentiating TB and non-TB samples as well as distinguishing TB and multidrug-resistant (MDR) TB samples. " 10/01/2021 - "A total of 8 studies (654 participants) reported the incidence rate indicators of multiple organ failure rate indicator, the obtained statistic value (OR =0.50, 95% CI: 0.24 to 1.08) showed no statistical difference between TEN and TPN (P>0.05). " 11/14/2007 - "Two hundred and thirty consecutive CSF samples collected from 156 patients clinically suspected of TBM on presentation at a tertiary referal hospital in Vietnam were enrolled into the study over a five month period and tested by Ziehl-Neelsen (ZN) smear, MODS, Mycobacterial growth Indicator tube (MGIT) and Lowenstein-Jensen (LJ) culture. " 10/01/2022 - "The proposed ECOFF/ECVs were then validated by comparing with the MIC distributions of high-confidence genetic variants that confer resistance and with qualitative drug susceptibility tests obtained via the Mycobacterial Growth Indicator Tube (MGIT) system or Microscopic-Observation Drug Susceptibility (MODS) assay. " 01/08/2021 - ", it can replace pulse indicator continuous cardiac output as an indicator for evaluating EVLW in patients with MODS treated with CBP."
8.	AntioxidantsIBA 01/01/2021 - "The purpose of this work was to explore the antioxidant, anti-inflammatory, and protective effects of GLP on the liver in MODS model mice. " 08/01/2008 - "The current study underlined the inhibition of plasma NO and IL-1beta as well as aortic O(2)(-) production and the reduction of PMN infiltration may lead to the amelioration of MODS, which may contribute to the beneficial effect of antioxidants (e.g. " 01/01/2023 - "Two mods of exercise (AE and RE) may be having same effects on nerve cell density, inflammatory, antioxidant and functional status of hippocampus of obese rats. " 01/01/2022 - "It can be said that long-term use of antioxidants and immunonutrition does not have a beneficial effect in patients with multiple organ failure with high APACHE-II scores." 07/21/2021 - "These conclusions indicated that SPLE had effective antioxidant and anti-inflammatory activities, and could be used as a functional food and medicine to prevent MODS."
9.	Intravenous Immunoglobulins (IVIG)FDA Link 09/01/2022 - "On multiple logistic regression, MODS ( p = 0.002) was independent predictor of mortality while IVIG treatment ( p = 0.004) was favorably associated with survival. " 04/01/2001 - "For the total group of patients with sepsis and septic shock, a reduction in mortality by IVIg could not be documented; however, in the SBITS study with 653 patients included, a moderate improvement in sepsis morbidity and multiple organ dysfunction syndrome was demonstrated. " 12/12/2012 - "Children with hyperferritinemia and secondary HLH/sepsis/MODS/MAS can be successfully treated with plasma exchange, intravenous immunoglobulin, and methylprednisone. " 09/01/2005 - "Two XLA patients died of multiple organ failure caused by severe neutropenia and Pseudomonas sepsis before initiation of IVIG replacement therapy. " 01/01/2022 - "All 3 fatal TEN (with >30% involvement of body surface and MODS) following unsuccessful treatment with corticosteroids and intravenous immunoglobulin. "
10.	C-Reactive ProteinIBA 04/01/2007 - "Treated patients had significant reduction in C-reactive protein levels, and by day 7 had lower LIS and multiple organ dysfunction syndrome scores. " 11/01/2021 - "Etiologies, C-reactive protein (CRP) levels, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and MODS were the factors influencing IPN. " 10/01/2015 - "Higher plasma levels of PTX3 and sST2, but not of hsCRP, at ICU admission were associated with higher risk of MODS and early death." 06/01/2014 - "In addition, 65 age- and sex-matched patients with pronounced MODS were assigned for comparison of autonomic function and C-reactive protein in patients with CHF or MODS, respectively. " 01/01/2022 - "Patients in the TZC group had a lower C reactive protein (CRP) at discharge, lower rate of multiple organ failure, better functional status at discharge and shorter hospital stay. "

Therapies and Procedures

1.	Therapeutics 01/01/2010 - "The addition of IABP to standard therapy did not result in a significant improvement in MODS (measured by serial APACHE II scoring over 4 days). " 04/01/2000 - "Yet, neither mortality nor multiple organ failure were significantly improved by the applied short-term adjuvant therapy. " 12/01/2016 - "CHM combined with conventional therapy was tested to be more effective in reduce mortality (RR=0.24, 95%CI:0.13-0.46, P<0.0001), reduce the incidence of MODS (RR=0.47, 95%CI: 0.34-0.66,P<0.00001), symptomatic improvement: increase blood pressure (BP) (MD=8.83, 95%CI:6.82-10.84,P<0.00001), regulate heart rate (MD=-7.6,95%CI:-9.17 to -6.02,P<0.00001), increase urine volume (MD=7.26, 95%CI:5.00-9.53, P<0.00001), compared with conventional therapy alone. " 05/01/1996 - "The ability to more accurately predict survival from MODS/MOSF can improve our ability to test new therapies, evaluate how outcome has changed over time, and assess the efficacy of supportive therapy for individuals." 11/01/2019 - "However, despite decades of clinical trials, there are no comprehensive approaches to the management of MODS or effective targeted therapies that have consistently improved outcomes. "
2.	Plasma Exchange 01/01/2023 - "Therapeutic plasma exchange (TPE) has been advocated as an effective treatment of MODS, but its role in SCD compared with RBCx alone is not well studied. " 05/01/1997 - "This study examined the efficacy of a different scoring system for multiple organ failure (MOF) patients treated by plasma exchange (PE). " 05/01/1997 - "Comparison of acute physiology and chronic health evaluation III and II for prediction of mortality in multiple organ failure patients treated by plasma exchange." 01/01/1990 - "Multiple organ failure--a role for plasma exchange?" 05/01/2015 - "Therapeutic plasma exchange as a strategy to reverse multiple organ dysfunction syndrome in patients receiving extracorporeal life support."
3.	Resuscitation 03/01/2017 - "These patients were more ill at presentation with significantly greater median pediatric index of mortality 2 (PIM2) scores and were more likely to receive recommended resuscitation in the ED (61% vs 14%); however, rates of NP-MODS (9% vs 12%) and hospital mortality (7% vs 4%) were similar to those treated later. " 01/01/2012 - "For the late resuscitation studies (n = 3), there was statistically significant difference [P = 0.05, I (2)=66%], and there was no significant effect on mortality (OR = 0.89, 95%CI 0.52-1.54, P = 0.68) and incidence of MODS (OR = 0.43, 95%CI 0.17-1.08, P = 0.07). " 07/01/2008 - "The aim of our prospective randomized study was to compare the effect of two different types of fluid resuscitation regimes on the multiple organ dysfunction score (MODS) and central venous oxygen saturation (ScvO(2)) in the first 3 days after injury. " 09/01/2022 - "Despite resuscitation efforts, he died of multiple organ failure on admission 3rd day. " 02/01/2022 - "Demographics, data on physiology, resuscitation, MODS/ARDS, and infectious complications were prospectively collected. "
4.	Continuous Renal Replacement Therapy 12/01/2012 - "The purpose of this paper was to investigate the efficacy of continuous veno-venous hemodiafiltration (CVVHDF) as treatment for MODS in an established animal model. " 01/01/2023 - "Continuous Venovenous Hemofiltration Performed by Neonatologists With Cardio-Renal Pediatric Dialysis Emergency Machine to Treat Fluid Overload During Multiple Organ Dysfunction Syndrome: A Case Series." 10/01/2022 - "We aimed to identify the predictor factors for death in pediatric patients with SHLH-associated MODS receiving continuous renal replacement therapy (CRRT). " 01/01/2019 - "Fluid balance after continuous renal replacement therapy initiation and outcome in paediatric multiple organ failure." 09/02/2018 - "Methods: The medical records of 5 patients diagnosed as KD with MODS treated with CVVHDF, who were admitted to pediatric intensive care unit (PICU) of Shanghai Children's Hospital from November 2015 to October 2017 were retrospectively collected. "
5.	Length of Stay 12/01/2021 - "Surgically treated patients had a significant reduction in lung failure (p = 0.013, OR = 0.74), multiple organ failure (p = 0.001, OR = 0.64), intubation time (p = 0.004; -1.81 days) and length of hospital stay (p = 0.014; -1.51 days) compared to non-operative treatment. " 05/24/2020 - "Thus, we proposed that an early stabilization of thoracolumbar spine fractures will result in significant benefits regarding respiratory organ function, multiple organ failure and length of ICU / hospital stay. " 01/01/2023 - "The presence of MODS on day 1 was associated with a longer PICU length of stay (LOS) (β = 5.4 [95% CI, 0.7-10.2]; p = 0.024) and over a six-fold increased risk of an LOS over 2 days (odds ratio, 6.08 [95% CI, 1.59-23.23]; p = 0.008). " 12/01/2022 - "We assessed the following outcomes: mortality, multiple organ dysfunction syndrome during PICU stay, and PICU length of stay (LOS). " 08/01/2022 - "Compared with non MODS group, APACHE II score [14 (10, 22) vs. 8 (6, 13)], SAPS II score [36 (32, 56) vs. 29 (24, 35)], SOFA score (7.9±3.9 vs. 4.0±3.8), in-hospital mortality [53.8% (21/39) vs. 0% (0/46)], Lac [mmol/L: 3.1 (2.3, 6.3) vs. 2.1 (1.4, 4.6)] and VE-cad levels [mg/L: 1.427 (1.156, 1.937) vs. 1.195 (0.897, 1.776)] in MODS group were significantly higher, the length of stay in EICU was significantly longer [days: 6 (3, 12) vs. 3 (0, 7)], and the PLT level was significantly lower (×109/L: 118.2±80.0 vs. 182.5±104.0, all P < 0.05). "