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Mucopolysaccharidosis IV (Morquio Syndrome)

Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.
Also Known As:
Morquio Syndrome; Morquio Disease; Eccentroosteochondrodysplasia; Galactosamine-6-Sulfatase Deficiency; Morquio B Syndrome; Morquio Syndrome A; Morquio Syndrome B; Morquio Syndrome, Type B; Morquio's Disease Type B; Morquio's Syndrome; Morquio-B Disease; Mucopolysaccharidosis 4; Mucopolysaccharidosis 4B; Mucopolysaccharidosis Type IV A; Mucopolysaccharidosis Type IV B; Mucopolysaccharidosis Type IVA; Mucopolysaccharidosis Type IVB; Deficiencies, Galactosamine-6-Sulfatase; Deficiency, Galactosamine-6-Sulfatase; Disease, Morquio; Disease, Morquio's; Disease, Morquio-B; Eccentro Osteochondrodysplasia; Eccentro-Osteochondrodysplasias; Eccentroosteochondrodysplasias; Galactosamine 6 Sulfatase Deficiency; Galactosamine-6-Sulfatase Deficiencies; Morquio B Disease; Morquios Disease; Morquios Syndrome; Mucopolysaccharidosis 4Bs; Mucopolysaccharidosis Type IVBs; Syndrome A, Morquio; Syndrome, Morquio B; Syndrome, Morquio's; Eccentro-Osteochondrodysplasia; Morquio's Disease
Networked: 191 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. GM1 Gangliosidosis (Gangliosidosis GM1)
2. Mucopolysaccharidosis III (Sanfilippo Syndrome)
3. Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
4. Mucopolysaccharidosis VII (Sly Syndrome)
5. Gangliosidoses (Gangliosidosis)

Experts

1. Suzuki, Yoshiyuki: 7 articles (05/2014 - 12/2003)
2. Giugliani, Roberto: 5 articles (05/2015 - 08/2004)
3. Nanba, Eiji: 5 articles (05/2014 - 12/2003)
4. Higaki, Katsumi: 5 articles (05/2014 - 12/2003)
5. Miled, A: 4 articles (02/2014 - 03/2006)
6. Chkioua, L: 4 articles (02/2014 - 03/2006)
7. Laradi, S: 4 articles (02/2014 - 03/2006)
8. Tomatsu, Shunji: 3 articles (08/2015 - 12/2010)
9. Mackenzie, William G: 3 articles (08/2015 - 07/2012)
10. Orii, Tadao: 3 articles (08/2015 - 12/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mucopolysaccharidosis IV:
1. GALNS deficiencyIBA
2. beta-Galactosidase (Lactaid)IBA
3. Galactose (Galactopyranose)FDA LinkGeneric
4. N-octyl-beta-valienamineIBA
5. GalactosidesIBA
6. 1-deoxygalactonojirimycinIBA
7. cyclohexenoesculetin-beta-galactoside (S-Gal)IBA
8. Keratan SulfateIBA
9. GlycosaminoglycansIBA
10. acid beta-galactosidaseIBA

Therapies and Procedures

1. Enzyme Replacement Therapy
2. Prosthodontics
3. Decompression
4. Arthrodesis
5. Transplants (Transplant)