The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.
Also Known As:
Networked: 626 relevant articles (8 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Chromosome Aberrations (Chromosome Abnormalities)
2. Neoplasm Metastasis (Metastasis)
3. Trisomy (Trisomies)
4. Melanoma (Melanoma, Malignant)
5. Leukemia


1. Shields, Carol L: 8 articles (02/2015 - 01/2007)
2. Jager, Martine J: 7 articles (03/2015 - 01/2007)
3. Shields, Jerry A: 7 articles (02/2015 - 01/2007)
4. Zeschnigk, Michael: 7 articles (01/2009 - 01/2003)
5. de Klein, Annelies: 5 articles (03/2014 - 09/2006)
6. Coupland, Sarah E: 5 articles (03/2013 - 01/2010)
7. Damato, Bertil: 5 articles (09/2012 - 10/2006)
8. Jordanova, Ekaterina S: 5 articles (08/2012 - 01/2007)
9. Ganguly, Arupa: 5 articles (02/2011 - 01/2007)
10. Materin, Miguel A: 5 articles (07/2010 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Monosomy:
1. Uveal melanomaIBA
01/01/2014 - "Finally, we showed in a multicenter, prospective study that our GEP assay is highly accurate for predicting which patients will develop metastatic disease, and it was significantly superior to the previous gold standard, chromosome 3 testing for monosomy 3. This is the only prognostic test in uveal melanoma ever to undergo such extensive validation, and it is currently being used in a commercial format under the trade name DecisionDx-UM in over 100 centers in the USA and Canada. "
03/01/2013 - "In the present study, whole-genome microarrays were used to interrogate four clinically well-defined subgroups of uveal melanoma: i) disomy 3 uveal melanoma with long-term survival; ii) metastasizing monosomy 3 uveal melanoma; iii) metastasizing disomy 3 uveal melanoma; and iv) monosomy 3 uveal melanoma with long-term survival. "
01/01/2007 - "To study the distribution of monosomy 3 in primary uveal melanoma by fluorescence in situ hybridization (FISH). "
09/01/2006 - "This study confirms previous results on the prognostic factors of uveal melanoma and on the value of monosomy 3. The increasingly precise identification of a group of high-risk patients should allow us to propose adjuvant therapy and to adapt follow-up."
04/01/1998 - "This study did not detect the presence of cryptic deletions but revealed instead complete chromosomal homozygosity or functional monosomy, which probably occurred by loss and then duplication of the remaining chromosome 3. The demonstration of acquired isodisomy (functional monosomy) in a subset of UM increases the percentage of cases with monosomy 3 and provides further evidence for a central role of chromosome 3 loss in the molecular pathogenesis of uveal melanoma."
2. monosomy Chromosome 7IBA
3. Peroxidase (Myeloperoxidase)IBA
4. Factor VIII (Coagulation Factor VIII)IBA
5. trisomy 7q Chromosome 7IBA
6. AnthracyclinesIBA
7. Cytarabine (Cytosar-U)FDA LinkGeneric
8. DNA (Deoxyribonucleic Acid)IBA
11/01/2009 - "By screening DNA from diagnosed AIS patients with oligonucleotide array-based comparative genomic hybridization (aCGH), we report a 1p36 monosomy in this study. "
07/15/2002 - "Fluorescence in situ hybridization (FISH) with a locus-specific dual DNA probe (LSI EGR-1SO/D5S23SG) for chromosome 5 was used in combination with morphology to study bone marrow cell lineage involvement of the abnormal chromosomal clone in 13 patients with deletion 5q [del(5q)], either as a sole aberration or as part of a complex karyotype, and in six cases with monosomy 5 by metaphase cytogenetics, all with complex karyotypes including 2-6 marker chromosomes. "
02/20/1997 - "In the present study, we describe at the molecular level the deletions found in the MTC of two (NHL) cases using, (i) DNA obtained from a patient (GUI) with a monosomy 3 and three microdeletions of 101, 22, 25 bp in its unique untranslocated 3q27 allele; (ii) a cell line derived from a patient (VAL) carrying a t(3;4) (q27;p11) translocation and a 2.4 Kbp deletion in the untranslocated allele. "
07/01/1994 - "The results of molecular DNA studies interpreted as allelic imbalance of distal 17p markers in most cases probably reflect chromosomal rearrangements like loss of specific loci, rather than monosomies and large deletions. "
01/01/1991 - "Conventional chromosomal analysis was performed in addition to RFLP studies of constitutive and granulocyte DNA using five polymorphisms from chromosome 5. Allelic loss in granulocyte DNA was identified in only one patient in whom monosomy 5 had already been defined cytogenetically. "
9. DNA ProbesIBA
10. Dacarbazine (DIC)FDA LinkGeneric

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Brachytherapy
3. Radiotherapy
01/01/2007 - "Transscleral fine-needle aspiration biopsy and FISH for monosomy 3 may provide important prognostic information on patients who undergo plaque radiotherapy for choroidal melanoma."
11/15/2011 - "The greater decrease in monosomy 3 melanoma thickness after brachytherapy is consistent with other malignancies in which more aggressive pathology has been shown to be associated with a greater initial response to radiotherapy."
10/01/2008 - "At the time of plaque radiotherapy, the median tumor thickness was 4.0 mm for melanomas with chromosome 3 monosomy and 3.5 mm for those with disomy 3. The median tumor thickness (% original thickness) at 4, 8, 12, 15, and 18 months after radiotherapy for melanoma with monosomy 3 was 77%, 67%, 58%, 55%, and 50% and for those with disomy 3 was 82%, 70%, 69%, 67%, and 61%. "
10/01/2007 - "Using FNAB at the time of plaque radiotherapy, monosomy 3 was found in approximately 27% of small choroidal melanomas, more often in older patients and tumors with documented growth. "
10/01/2008 - "The median monthly regression rate was 3.1% for tumors with monosomy 3 and 2.7% for those with disomy 3. The overall regression and monthly rate of regression was statistically greater at 12 months (P < 0.001) and 15 months (P = 0.003) for melanomas with monosomy 3 compared with disomy 3. Uveal melanomas with chromosome 3 monosomy showed faster and greater tumor thickness regression at 12 and 15 months after plaque radiotherapy and thermotherapy than melanomas with disomy 3."
4. Induced Hyperthermia (Thermotherapy)
5. Transplants (Transplant)