Monoacylglycerol Lipases

An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.

Also Known As:

Monoglyceride Hydrolase; Esterase, Monoglyceride; Esterases, Monoglyceride; Hydrolase, Glycerol Monoester; Hydrolase, Monoglyceride; Hydrolases, Glycerol Monoester; Lipase, Monoacylglycerol; Lipase, Monoglyceride; Lipases, Monoacylglycerol; Lipases, Monoglyceride; Monoester Hydrolase, Glycerol; Monoester Hydrolases, Glycerol; Glycerol Monoester Hydrolase; Glycerol Monoester Hydrolases; Monoacylglycerol Lipase; Monoglyceride Esterase; Monoglyceride Esterases; Monoglyceride Lipase; Monoglyceride Lipases; Glycerol-ester acylhydrolase

Networked: 237 relevant articles (7 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Carboxylic Ester Hydrolases: 62
        Monoacylglycerol Lipases: 237
        Aspergillus oryzae lipolytic enzyme L2
        human ABHD12 protein
        human ABHD16A protein
        human ABHD6 protein
        human MGLL protein
        mouse Abhd12 protein
        mouse ABHD16A protein
        mouse ABHD6 protein
        mouse Ces2g protein
        mouse Mgll protein
        rat ABHD16A protein
        S cerevisiae MGL2 protein
        S cerevisiae Yju3 protein

Experts

1.	Cravatt, Benjamin F: 19 articles (10/2021 - 01/2010)
2.	Lichtman, Aron H: 11 articles (01/2021 - 12/2010)
3.	Niphakis, Micah J: 8 articles (01/2021 - 02/2015)
4.	Nomura, Daniel K: 8 articles (07/2015 - 09/2008)
5.	Granchi, Carlotta: 5 articles (02/2022 - 11/2016)
6.	Chen, Chu: 5 articles (01/2022 - 11/2012)
7.	Zhang, Jian: 5 articles (01/2022 - 11/2012)
8.	Kinsey, Steven G: 5 articles (01/2021 - 12/2010)
9.	Limebeer, Cheryl L: 5 articles (07/2018 - 04/2012)
10.	Parker, Linda A: 5 articles (07/2018 - 04/2012)

Related Diseases

1.	Neuroinflammatory Diseases 08/21/2015 - "Monoacylglycerol lipase (MAGL) is important for neuroinflammation. " 01/01/2018 - "Inhibiting of monoacylglycerol lipase modulates synaptic activity and neuroinflammation, 2 mediators of excessive neuronal activation underlying seizures. " 07/29/2022 - "Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders." 10/01/2019 - "Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2." 12/01/2018 - "Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). "
2.	Hyperalgesia 12/01/2010 - "Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors reduced allodynia through distinct cannabinoid receptor mechanisms. " 03/19/2013 - "The present study tested whether the selective monoacylglycerol lipase (MAGL) inhibitor JZL184 would reduce allodynia and paw edema in the carrageenan test. " 01/01/2022 - "Pristimerin, a triterpene that inhibits monoacylglycerol lipase activity, prevents the development of paclitaxel-induced allodynia in mice." 01/01/2023 - "Pharmacological inhibition of the 2-arachidonoylglycerol hydrolyzing enzymes, α/β-hydrolase domain-containing 6 and monoacylglycerol lipase reversed and prevented induced periorbital allodynia in a cannabinoid receptor-dependent manner. " 06/15/2021 - "All irreversible inhibitors of anandamide hydrolase (MAFP), the inhibitor for monoacylglycerol lipase (JZL184) and the anandamide reuptake inhibitor (VDM11) decreased carrageenan-induced hyperalgesia in muscular tissue. "
3.	Body Weight (Weight, Body) 02/13/1976 - "The activity of monoglyceride lipase was studied in plasma from 74 patients with liver disease in whom blood was drawn 10 min after the injection of heparin (10 U/kg body weight). " 01/01/2020 - "The present study investigated the effects of HT, a new prospective weight-loss method, on nutritionally obese mice and demonstrated that HT significantly reduced body weight, fat mass, transcriptional expression of liver endocannabinoid receptor 1 (CB1), biosynthetic enzyme diacylglycerol lipase α (DAGLα) and improved the transcriptional expression of degrading enzyme monoacylglycerol lipase (MAGL). " 10/01/1995 - "The activity of pancreatic (alpha-amylase, protease, and lipase) and enteral (maltase, glycyl-L-leucine dipeptidase, monoglyceride lipase) was studied in the experiments on adult male Wistar rats weighting 350 +/- 35 g 1-3, 7, 10, 30, 60, and 90 days after injection of a single dose of 25 mg per 100 g body weight. "
4.	Hypoxia (Hypoxemia) 01/01/1984 - "Hypoxic-hypoxia and 30-s postdecapitation ischemia resulted in a considerable increase in monoacylglycerol lipase activity of rat brain. " 01/01/1984 - "The increased activity of monoacylglycerol lipase during hypoxic-hypoxia and short-time ischemia may be partially responsible for increased levels of free fatty acids during these processes." 01/01/2023 - "Monoacylglycerol Lipase Inhibitor JJKK048 Ameliorates ABCG2 Transporter-Mediated Regorafenib Resistance Induced by Hypoxia in Triple Negative Breast Cancer Cells." 10/01/2012 - "This study was undertaken to assess whether preventing the deactivation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with the monoacylglycerol lipase (MAGL) inhibitor URB602 can provide neuroprotective effects in hypoxia-ischemia (HI)-induced brain injury. "
5.	Weight Loss (Weight Reduction) 01/01/2020 - "The present study investigated the effects of HT, a new prospective weight-loss method, on nutritionally obese mice and demonstrated that HT significantly reduced body weight, fat mass, transcriptional expression of liver endocannabinoid receptor 1 (CB1), biosynthetic enzyme diacylglycerol lipase α (DAGLα) and improved the transcriptional expression of degrading enzyme monoacylglycerol lipase (MAGL). "

Related Drugs and Biologics

1.	Endocannabinoids
2.	Enzymes
3.	fatty-acid amide hydrolase (fatty acid amide hydrolase)
4.	Hydrolases
5.	JZL 184
6.	Fatty Acids (Saturated Fatty Acids)
7.	Lipoprotein Lipase (Diacylglycerol Lipase)
8.	anandamide (arachidonylethanolamide)
9.	Glycerol (Glycerine)
10.	Serine (L-Serine)

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Therapeutics
3.	Ketogenic Diet
4.	Resuscitation
5.	Induced Hypothermia