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Mitral Valve Insufficiency (Mitral Regurgitation)

Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
Also Known As:
Mitral Regurgitation; Mitral Insufficiency; Mitral Valve Regurgitation; Incompetence, Mitral; Incompetence, Mitral Valve; Insufficiency, Mitral; Insufficiency, Mitral Valve; Regurgitation, Mitral; Regurgitation, Mitral Valve; Valve Incompetence, Mitral; Valve Insufficiency, Mitral; Valve Regurgitation, Mitral; Mitral Incompetence; Mitral Valve Incompetence
Networked: 2264 relevant articles (128 outcomes, 190 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Heart Failure
2. Pulmonary Hypertension (Ayerza Syndrome)
3. Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
4. Rupture
5. Bundle-Branch Block (Fascicular Block)

Experts

1. Lancellotti, Patrizio: 16 articles (01/2015 - 12/2004)
2. Maisano, Francesco: 15 articles (03/2015 - 05/2003)
3. Liang, David: 15 articles (08/2009 - 05/2002)
4. Sawa, Yoshiki: 14 articles (10/2015 - 12/2008)
5. Bax, Jeroen J: 14 articles (04/2015 - 05/2005)
6. Alfieri, Ottavio: 14 articles (01/2015 - 05/2003)
7. Miller, D Craig: 14 articles (06/2008 - 05/2002)
8. Ingels, Neil B: 14 articles (06/2008 - 05/2002)
9. Magne, Julien: 13 articles (06/2015 - 02/2007)
10. Daughters, George T: 13 articles (06/2008 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mitral Valve Insufficiency:
1. DobutamineFDA LinkGeneric
2. EnalaprilFDA LinkGeneric
3. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
4. Carbon MonoxideIBA
5. Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
6. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
7. OxygenIBA
03/15/2003 - "Responders had significant improvement in 6-minute hall-walking distance (p = 0.006), metabolic equivalents (p = 0.02), peak oxygen uptake (p = 0.02), New York Heart Association functional class (p <0.001), and quality of life (p <0.001); an increase in the sphericity index (p = 0.007), ejection fraction (p <0.001), and diastolic filling time (p = 0.03); a decrease in myocardial performance index (p = 0.02), isovolumic relaxation time (p = 0.004), and mitral regurgitation (p = 0.007); and an improvement in systolic dyssynchrony (SD of the time to peak myocardial systolic contraction of the 12 LV segments as dyssynchrony index) (45.0 +/- 8.3 vs 32.5 +/- 14.5 ms, p = 0.003). "
04/01/2006 - "The 67 patients completing the study presented with the following characteristics: age (70 +/- 10 years; 11 women); etiology (idiopathic in 44, ischemic in 23); NYHA class (40 in class III and 27 in class IV); LVEF 26% (+/-5%); QRS duration (190 +/- 28 ms); 6-minute walk test 330 m (+/-108); peak oxygen uptake 10.7 (+/-3.3 mL/kg/min); mitral insufficiency in 42 (> or =III grade); interventricular (IV) delay (62 +/- 21 ms); and intraventricular dyssynchrony in 30 patients. "
12/01/1996 - "The objective of this study was to evaluate whether chronic severe mitral regurgitation leads to an artifactual elevation of mixed venous oxygen saturation. "
03/01/2011 - "Group 2 subjects had lower exercise capacity (peak (VO2, 45.7%±11.8% vs 50.4±8.9% predicted; P<.05), with a significantly lower oxygen pulse (71.6%±24.5% vs 85.4±18.5% predicted) and maximum systolic BP (122±19 mm Hg vs 138±22 mm Hg; P<.001 for both), suggesting a more blunted stroke volume to exercise vs group 1. There were no differences in left ventricular (LV) size, LVEF, or mitral regurgitation between the two groups. "
01/01/2007 - "Left ventricle diastolic diameter decreased from 69.8+/-8 to 67.5+/-10.0 mm (n=88, p=0.001) and mitral regurgitation was reduced from 2.2+/-0.9 to 1.9+/-0.9 (n=87, p=0.001) and maximum oxygen uptake during spiroergometry increased from 14.5+/-2.7 to 15.5+/-2.6 ml/min/kg (n=52, p=0.005). "
8. Nifedipine (Adalat)FDA LinkGeneric
9. Vasodilator Agents (Vasodilators)IBA
10. Nitroglycerin (Dynamite)FDA LinkGeneric

Therapies and Procedures

1. Cardiac Resynchronization Therapy
2. Mitral Valve Annuloplasty
03/01/2012 - "Although combined restrictive mitral annuloplasty and revascularization has demonstrated good results with regard to improvement of clinical status, low rates of recurrent mitral regurgitation and sustained left ventricular reverse remodeling, a survival benefit still has not been demonstrated. "
08/01/2009 - "Patients undergoing tricuspid annuloplasty did not show any improvement of systolic pulmonary arterial pressure, right ventricular ejection fraction, and tricuspid annular plane systolic excursion regardless of the recurrence of chronic ischemic mitral regurgitation (P = not significant), although effective restrictive mitral annuloplasty improved tricuspid insufficiency grading, New York Heart Association, and daily diuretic need (P <or= .010). "
02/01/1985 - "In the presence of major symptoms, mitral annuloplasty offers symptomatic relief for some patients with mitral systolic click syndrome without valve incompetence, but it gives substantially better results in patients with mitral regurgitation."
08/01/2009 - "Recurrent chronic ischemic mitral regurgitation in patients without tricuspid surgery prevented improvements of systolic pulmonary arterial pressure, tricuspid annular plane systolic excursion, right ventricular ejection fraction, worsening New York Heart Association (P = .003), and daily diuretic need (P = .008), whereas effective restrictive mitral annuloplasty progressively improved tricuspid insufficiency grading, systolic pulmonary arterial pressure, right ventricular ejection fraction, tricuspid annular plane systolic excursion, New York Heart Association, and diuretic need (P <or= .013). "
08/01/2009 - "Despite restrictive mitral annuloplasty (RMA) being considered effective for chronic ischaemic mitral regurgitation (CIMR), few data exist on mid-term echocardiographic results with different prosthetic rings. "
3. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4. Surgical Instruments (Clip)
5. Prostheses and Implants (Prosthesis)