|2.||Pulmonary Hypertension (Ayerza Syndrome)
|3.||Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
|5.||Bundle-Branch Block (Fascicular Block)
|1.||Lancellotti, Patrizio: 16 articles (01/2015 - 12/2004)|
|2.||Maisano, Francesco: 15 articles (03/2015 - 05/2003)|
|3.||Liang, David: 15 articles (08/2009 - 05/2002)|
|4.||Sawa, Yoshiki: 14 articles (10/2015 - 12/2008)|
|5.||Bax, Jeroen J: 14 articles (04/2015 - 05/2005)|
|6.||Alfieri, Ottavio: 14 articles (01/2015 - 05/2003)|
|7.||Miller, D Craig: 14 articles (06/2008 - 05/2002)|
|8.||Ingels, Neil B: 14 articles (06/2008 - 05/2002)|
|9.||Magne, Julien: 13 articles (06/2015 - 02/2007)|
|10.||Daughters, George T: 13 articles (06/2008 - 05/2002)|
10/01/1989 - "Dobutamine caused a marked rise in mean forward stroke volume (43 to 61 ml), with a decrease in mitral regurgitation volume from 20 to 10 ml/beat and a drop in pulmonary capillary wedge pressure from 21 to 13 mm Hg. Since the pressure gradient between the left ventricle and atrium increased significantly during dobutamine therapy, only a marked decrease in the orifice of regurgitation could explain the changes in regurgitant volume. "
11/01/2010 - "Dobutamine-induced improvement in inferior myocardial contractile function predicts reduction in functional mitral regurgitation: a study using tissue Doppler strain rate imaging."
08/01/2005 - "Relation between reduction in ischaemic mitral regurgitation and improvement in regional left ventricular contractility during low dose dobutamine stress echocardiography."
02/01/2014 - "The impact of segmental volumetric changes on functional mitral regurgitation: a study using three-dimensional regional time-volume analysis combined with low-dose dobutamine."
01/01/1995 - "Future studies are necessary, with large numbers of patients, to determine the effects of mitral regurgitation on the sensitivity and specificity of dobutamine stress echocardiography."
07/01/2005 - "Enalapril was associated with a significant reduction in left ventricular diameter and mitral regurgitation volume, with no evidence of change in systolic function indexes. "
11/01/1999 - "The data showed that for pediatric patients single-dose treatment with oral enalapril reduces the severity of mitral regurgitation and improves left ventricular loading conditions and systolic performance without impairment of myocardial contractility. "
04/01/2014 - "Heart rate variability (HRV) and echocardiography were performed in 14 dogs with mitral regurgitation (MR) before and after 14 days of 0.5mg/kg/day of enalapril treatment. "
07/01/2005 - "The effects of 12 months of therapy were evaluated in 47 mildly symptomatic patients with moderate to severe mitral valve regurgitation; 26 patients received enalapril and 21 received a placebo. "
09/01/2002 - "And Clinical Relevance: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation."
|3.||Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
02/01/2011 - "Lessons learned from a pediatric clinical trial: the Pediatric Heart Network angiotensin-converting enzyme inhibition in mitral regurgitation study."
03/01/2009 - "This study did not identify beneficial long-term changes in the severity of mitral regurgitation after addition of PIMO to angiotensin converting enzyme inhibitor treatment of dogs with asymptomatic MVD."
03/01/2004 - "This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements. "
05/01/1994 - "To date, no controlled study has been reported analyzing the long term influence of angiotensin-converting enzyme inhibitor treatment on patients with chronic mitral regurgitation. "
02/01/2011 - "We hypothesized that angiotensin-converting enzyme inhibitor therapy would decrease the severity of mitral regurgitation and limit left ventricular volume overload in children following AVSD repair. "
10/01/2006 - "LV systolic function significantly improved 48 h after switching from RVp to BiVp: Ao-VTI (p<0.001), SV (p<0.001) and CO (p<0.001), and mitral regurgitation significantly decreased (p=0.003). "
05/01/2014 - "We applied a co-aptation index using three-dimensional (3D) transoesophageal echocardiography to FMR and MR secondary to LA dilatation (atrial mitral regurgitation, AMR). "
05/01/2014 - "Functional mitral regurgitation (FMR) is a consequence of mitral annular enlargement, leaflet tethering and reduced co-aptation. "
01/01/2014 - "Percutaneous MitraClip implantation has been demonstrated as an alternative procedure in high-risk patients with symptomatic severe mitral regurgitation (MR) who are not suitable (or) denied mitral valve repair/replacement due to excessive co morbidity. "
09/01/2013 - "CRT interruption resulted in a significant worsening of left ventricular systolic function: reduction of cardiac output (CO), dP/dt, and left ventricular ejection fraction (LVEF), as well as deterioration of mitral regurgitation in the CRT responder group. "
|5.||Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
04/01/1979 - "Infusion of nitroprusside resulted in a significant reduction in mitral regurgitation. "
08/01/1998 - "Specifically, VCW decreased in 16 patients (improved mitral regurgitation), remained unchanged in 7 patients and increased in 8 patients (worsened mitral regurgitation) with nitroprusside. "
08/01/1998 - "Finally, short-term vasodilation with nitroprusside may significantly worsen the severity of mitral regurgitation in some patients."
08/01/1998 - "VCW, effective regurgitant orifice area and regurgitant volume were measured by quantitative Doppler mapping in 31 patients with chronic mitral regurgitation at baseline and during nitroprusside infusion. "
08/01/1985 - "The acute hemodynamic responses to nitroprusside during cardiac catheterization were evaluated in 12 children with isolated mitral regurgitation (MR) of congenital origin. "
|6.||Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
12/01/2011 - "Improving ventricular function with ACE inhibitors, beta-blockers and CRT may reduce mitral regurgitation, but for most patients a mechanical intervention is ultimately preferable. "
05/01/2010 - "Echocardiographic parameters (left ventricular end-diastolic diameter, left ventricular posterior wall diameter, interventricular septum diameter, left atrium to aortic root diameter ratio, grade of mitral valve regurgitation, shortening fraction) were analyzed before and during therapy with angiotensin-converting enzyme inhibitors in 12 patients and compared with 12 patients without medications after one month and one year. "
05/01/2010 - "This was a case-control study of all echocardiograms of patients with moderate-to-severe mitral valve regurgitation, who underwent chronic administration of angiotensin-converting enzyme inhibitors between January 1990 and December 2006 at a single center. "
05/01/2010 - "To investigate the effectiveness of chronic administration of angiotensin-converting enzyme inhibitors in pediatric patients with mitral valve regurgitation. "
05/01/2010 - "Angiotensin-converting enzyme inhibitors in pediatric patients with mitral valve regurgitation-case-control study and review of the literature."
03/15/2003 - "Responders had significant improvement in 6-minute hall-walking distance (p = 0.006), metabolic equivalents (p = 0.02), peak oxygen uptake (p = 0.02), New York Heart Association functional class (p <0.001), and quality of life (p <0.001); an increase in the sphericity index (p = 0.007), ejection fraction (p <0.001), and diastolic filling time (p = 0.03); a decrease in myocardial performance index (p = 0.02), isovolumic relaxation time (p = 0.004), and mitral regurgitation (p = 0.007); and an improvement in systolic dyssynchrony (SD of the time to peak myocardial systolic contraction of the 12 LV segments as dyssynchrony index) (45.0 +/- 8.3 vs 32.5 +/- 14.5 ms, p = 0.003). "
04/01/2006 - "The 67 patients completing the study presented with the following characteristics: age (70 +/- 10 years; 11 women); etiology (idiopathic in 44, ischemic in 23); NYHA class (40 in class III and 27 in class IV); LVEF 26% (+/-5%); QRS duration (190 +/- 28 ms); 6-minute walk test 330 m (+/-108); peak oxygen uptake 10.7 (+/-3.3 mL/kg/min); mitral insufficiency in 42 (> or =III grade); interventricular (IV) delay (62 +/- 21 ms); and intraventricular dyssynchrony in 30 patients. "
12/01/1996 - "The objective of this study was to evaluate whether chronic severe mitral regurgitation leads to an artifactual elevation of mixed venous oxygen saturation. "
03/01/2011 - "Group 2 subjects had lower exercise capacity (peak (VO2, 45.7%±11.8% vs 50.4±8.9% predicted; P<.05), with a significantly lower oxygen pulse (71.6%±24.5% vs 85.4±18.5% predicted) and maximum systolic BP (122±19 mm Hg vs 138±22 mm Hg; P<.001 for both), suggesting a more blunted stroke volume to exercise vs group 1. There were no differences in left ventricular (LV) size, LVEF, or mitral regurgitation between the two groups. "
01/01/2007 - "Left ventricle diastolic diameter decreased from 69.8+/-8 to 67.5+/-10.0 mm (n=88, p=0.001) and mitral regurgitation was reduced from 2.2+/-0.9 to 1.9+/-0.9 (n=87, p=0.001) and maximum oxygen uptake during spiroergometry increased from 14.5+/-2.7 to 15.5+/-2.6 ml/min/kg (n=52, p=0.005). "
|8.||Nifedipine (Adalat)FDA LinkGeneric
01/01/1987 - "At both altitudes corinfar resulted in the improvement of the patients' general status, postexercise recovery reduction, a decrease in PPA and mitral regurgitation volume, and an increase in the efficacy of cardiac pump function. "
11/01/1985 - "An additional 6 dogs with mitral regurgitation were followed for 30 min without nifedipine (group 3). "
11/01/1985 - "Mechanisms for improvement of cardiac performance by nifedipine in an acute mitral regurgitation in dogs."
11/01/1985 - "This study suggests that the mechanisms responsible for the improvement of cardiac performance induced by nifedipine in heart failure caused by an acute mitral regurgitation are essentially a reduction in left ventricular afterload and an increase in left ventricular contractility secondary to afterload reduction."
05/01/1979 - "In patients with hypertensive (seven cases), primary (seven cases) or rheumatic (aortic insufficiency five cases, mitral regurgitation five cases) cardiac disease, nifedipine, administered in a single sublingual dose (10 mg), relieved acute pulmonary edema. "
|9.||Vasodilator Agents (Vasodilators)IBA
07/01/1999 - "Vasodilators and inotropic drugs are effective in the management of functional mitral regurgitation. "
11/01/1989 - "Symptom-limited supine bicycle exercise with radionuclide angiography was performed on 11 patients with severe mitral regurgitation (who were not receiving vasodilators), to assess changes in left ventricular volume, regurgitant fraction, forward flow and regurgitant flow during exercise. "
11/01/1986 - "Although vasodilators improve cardiac output in severe left ventricular (LV) failure, the degree to which reduction in mitral regurgitation (MR) contributes to this response is unknown. "
04/01/1979 - "Reduction of ventricular volume rather than the traditional concept of reduction of impedance of left ventricular ejection may explain the effects of vasodilators in reducing mitral regurgitation."
10/01/1973 - "Beneficial effects of vasodilator agents in severe mitral regurgitation due to dysfunction of subvalvar apparatus."
|10.||Nitroglycerin (Dynamite)FDA LinkGeneric
07/01/1986 - "Improvement in forward cardiac output without a change in ejection fraction during nitroglycerin therapy in patients with functional mitral regurgitation."
09/01/1986 - "Dynamics of mitral regurgitation during nitroglycerin therapy: a Doppler echocardiographic study."
08/01/2004 - "Sixty patients without residual mitral regurgitation were divided into two groups according to the changes in the left atrial (LA) pressure 15 min after successful BMV: 18 patients (group A) did not present with any reduction in LA pressure, and underwent nitroglycerin administration (0.4 mg, sublingually). "
01/01/1994 - "The preservation of stroke volume despite a marked reduction in left ventricular filling pressure can be explained by a reduction in pericardial constraint and of mitral regurgitation induced by nitroglycerin. "
11/01/1987 - "To evaluate the potential value of nitrate therapy in patients with chronic mitral regurgitation, the hemodynamic and angiographic effects of intravenous nitroglycerin were studied in 10 such patients. "
|1.||Cardiac Resynchronization Therapy
06/01/2006 - "Atrioventricular (AV) interval optimization, ensuring the best filling and the abolishment of presystolic mitral regurgitation, is crucial for the efficacy of cardiac resynchronization therapy (CRT). "
03/01/2014 - "Compared with standard biventricular pacing, the final optimized pacing configuration improved global intraventricular synchrony (decreasing LPEI from 158 ± 36 ms to 134 ± 29 ms; P<0.001), LV systolic efficiency (decreasing LPEI/LV ejection time from 0.58 ± 0.18 to 0.46 ± 0.13; P<0.001) and LV filling (increasing LV filling time/RR from 44 ± 8% to 47 ± 7%; P<0.001) and decreased mitral valve regurgitation. "
10/19/2004 - "We tested the hypothesis that an immediate reduction in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT) results from improved coordinated timing of the papillary muscle insertion sites, using the novel approach of mechanical activation strain mapping. "
03/01/2008 - "The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). "
11/20/2007 - "The purpose of this study was to evaluate the relationship between dyssynchrony involving the mitral valve apparatus and the acute improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). "
|2.||Mitral Valve Annuloplasty
03/01/2012 - "Although combined restrictive mitral annuloplasty and revascularization has demonstrated good results with regard to improvement of clinical status, low rates of recurrent mitral regurgitation and sustained left ventricular reverse remodeling, a survival benefit still has not been demonstrated. "
08/01/2009 - "Patients undergoing tricuspid annuloplasty did not show any improvement of systolic pulmonary arterial pressure, right ventricular ejection fraction, and tricuspid annular plane systolic excursion regardless of the recurrence of chronic ischemic mitral regurgitation (P = not significant), although effective restrictive mitral annuloplasty improved tricuspid insufficiency grading, New York Heart Association, and daily diuretic need (P <or= .010). "
02/01/1985 - "In the presence of major symptoms, mitral annuloplasty offers symptomatic relief for some patients with mitral systolic click syndrome without valve incompetence, but it gives substantially better results in patients with mitral regurgitation."
08/01/2009 - "Recurrent chronic ischemic mitral regurgitation in patients without tricuspid surgery prevented improvements of systolic pulmonary arterial pressure, tricuspid annular plane systolic excursion, right ventricular ejection fraction, worsening New York Heart Association (P = .003), and daily diuretic need (P = .008), whereas effective restrictive mitral annuloplasty progressively improved tricuspid insufficiency grading, systolic pulmonary arterial pressure, right ventricular ejection fraction, tricuspid annular plane systolic excursion, New York Heart Association, and diuretic need (P <or= .013). "
08/01/2009 - "Despite restrictive mitral annuloplasty (RMA) being considered effective for chronic ischaemic mitral regurgitation (CIMR), few data exist on mid-term echocardiographic results with different prosthetic rings. "
|3.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)
08/01/2015 - "Efficacy of mitral valve repair as an adjunct procedure to coronary artery bypass grafting in moderate ischemic mitral regurgitation: a meta-analysis of randomized trials."
08/01/2009 - "POINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with moderate ischemic mitral valve regurgitation: a randomized trial."
01/01/2012 - "This is an ongoing prospective, multicenter, randomized, controlled clinical trial designed to test the safety and efficacy of mitral repair in addition to coronary artery bypass grafting in the treatment of moderate ischemic mitral regurgitation. "
08/01/2009 - "The efficacy of adding mitral valve repair to coronary artery bypass grafting is well demonstrated by the improvement of New York Heart Association functional class and percentage of left ventricular ejection fraction and by the decrease of mitral regurgitation grade, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, pulmonary artery pressure, and left atrial size. "
08/01/2009 - "COUNTERPOINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with moderate ischemic mitral valve regurgitation."
|4.||Surgical Instruments (Clip)
05/01/2000 - "All patients had good results immediately following surgical valve mitral repair, with no more than mild mitral regurgitation and low transmitral gradients on intraoperative transesophageal echocardiography. "
01/01/2015 - "The details are reported of a novel treatment strategy using two-clip delivery systems (2CDS) simultaneously, after double trans-septal puncture, for the treatment of severe functional mitral regurgitation. "
01/01/2015 - "We report on a novel treatment strategy using two clip delivery systems (CDS) simultaneously, after double transseptal puncture, for treatment of severe functional mitral regurgitation. "
07/01/2009 - "Another technique in patients with degenerative mitral regurgitation is the endovascular edge-to-edge repair in which coaptation of the mitral valve leaflets can be improved with a percutaneously deployed clip. "
12/01/2015 - "As many as 50% of patients with severe symptomatic mitral valve regurgitation are denied surgical valve replacement or repair due to high operative risk. "
|5.||Prostheses and Implants (Prosthesis)
04/01/2005 - "An annular prosthesis with selective reduction in the septolateral dimension is more effective than a conventional prosthesis for treating leaflet tethering in functional mitral regurgitation. "
06/01/1990 - "Carpentier's techniques of prosthetic ring mitral valve repair for mitral regurgitation offer the potential for immediate and long-term improvement in valve function without the necessity of replacing the native valve with a prosthesis. "
10/01/2012 - "The second patient had improved normally with a functioning prosthesis after the deployment of two devices, but had progressively worsening mitral regurgitation for which re-operation at the sixteenth month of follow-up was necessary. "
08/01/2014 - "Improvements in diastolic function and mitral regurgitation are reported in only a handful of studies each and could not be compared across prosthesis types. "
12/01/1994 - "Study of all mitral prostheses in which pathological mitral regurgitation had been detected by multiplanar TEE, between January 1993 and March 1994. "