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Mitotane (Lysodren)

A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Also Known As:
Lysodren; Bristol-Myers Squibb Brand of Mitotane; Chloditan; Chlodithane; Khloditan; Mytotan; Bristol Myers Squibb Brand of Mitotane; ortho,para DDD; o,p-DDD; ortho,para-DDD; Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-
Networked: 409 relevant articles (41 outcomes, 28 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Terzolo, Massimo: 16 articles (02/2015 - 09/2005)
2. Fassnacht, Martin: 14 articles (11/2015 - 04/2005)
3. Allolio, Bruno: 13 articles (11/2015 - 06/2006)
4. Baudin, Eric: 12 articles (08/2015 - 01/2006)
5. Berruti, Alfredo: 10 articles (02/2015 - 09/2005)
6. Young, Jacques: 9 articles (12/2015 - 01/2006)
7. Leboulleux, Sophie: 9 articles (02/2015 - 01/2006)
8. Volante, Marco: 7 articles (02/2015 - 12/2008)
9. Schlumberger, Martin: 7 articles (02/2015 - 01/2006)
10. Berruti, A: 7 articles (03/2014 - 06/2000)

Related Diseases

1. Adrenocortical Carcinoma
2. Neoplasms (Cancer)
3. Cushing Syndrome
4. Adrenal Cortex Neoplasms (Adrenocortical Cancer)
5. Neoplasm Metastasis (Metastasis)

Related Drugs and Biologics

1. Mitotane (Lysodren)
2. Aminoglutethimide (Cytadren)
3. Hydrocortisone (Cortisol)
4. Ketoconazole (Nizoral)
5. Metyrapone
6. Adrenocorticotropic Hormone (ACTH)
7. Doxorubicin (Adriamycin)
8. Etoposide (VP 16)
9. Cisplatin (Platino)
10. Hormones

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Adrenalectomy
3. Radiotherapy
4. Adjuvant Chemotherapy
5. Pituitary Irradiation