|1.||Terzolo, Massimo: 16 articles (02/2015 - 09/2005)|
|2.||Fassnacht, Martin: 14 articles (11/2015 - 04/2005)|
|3.||Allolio, Bruno: 13 articles (11/2015 - 06/2006)|
|4.||Baudin, Eric: 12 articles (08/2015 - 01/2006)|
|5.||Berruti, Alfredo: 10 articles (02/2015 - 09/2005)|
|6.||Young, Jacques: 9 articles (12/2015 - 01/2006)|
|7.||Leboulleux, Sophie: 9 articles (02/2015 - 01/2006)|
|8.||Volante, Marco: 7 articles (02/2015 - 12/2008)|
|9.||Schlumberger, Martin: 7 articles (02/2015 - 01/2006)|
|10.||Berruti, A: 7 articles (03/2014 - 06/2000)|
07/01/2001 - "The excellent follow-up of these patients suggests that even in hopeless cases with metastatic adrenocortical carcinoma, mitotane should be administered for very long periods of time as it can be well-tolerated and may be beneficial in the long run."
01/01/1994 - "Complete remission of metastasized adrenocortical carcinoma under o,p'-DDD."
07/01/1990 - "Unlike previous reports of metastatic adrenal cortical carcinoma in which complete remission was obtained with high dose Mitotane treatment, the dose of Mitotane used in this patient was low. "
06/01/2009 - "Metastatic virilizing adrenocortical carcinoma: a rare case of cure with surgery and mitotane therapy."
01/01/2001 - "For adrenocortical carcinoma, adjunctive treatment with oral mitotane leads to well-documented improvement of survival. "
02/01/2013 - "Mitotane, an adrenolytic agent, is the mainstay of treatment after surgical removal of the tumor. "
01/01/2009 - "The objective of the study was to profile human adrenal tumors and ACC cell lines to assess activated IGF signaling and determine the efficacy of two IGF receptor (IGF-1R) antagonists alone and in combination with mitotane. "
06/01/1998 - "We conclude that monitoring serum concentrations of mitotane makes long-term treatment possible with few side effects; steroid profile analysis can be used for early detection of tumor recurrence; and repeat surgery for recurrence is of value for patients with long disease-free intervals."
01/01/1982 - "Treatment with methyrapone, o,p'DDD, and irradiation of the tumor resulted in a lasting remission. "
08/01/2015 - "Finally, retrospective study of an ACC cohort of 26 mitotane-treated patients revealed that statin therapy was significantly associated with a higher rate of tumor control. "
09/01/2011 - "Mitotane is highly effective in the long-term management of Cushing's syndrome but has a slow onset of action. "
10/01/2000 - "Furthermore, we used mitotane with good results in Cushing's syndrome of non-malignant origin as pre-treatment before surgery or in long-term treatment for patients with poor tolerance of other adrenal inhibitors."
04/01/2014 - "The efficacy of adjuvant mitotane does not seem to be influenced by overt hypercortisolism."
03/01/1966 - "Remission in Cushing's syndrome with o,p'-DDD."
01/01/1999 - "[Effects of mitotane therapy in dogs with pituitary dependent Cushing syndrome on the adrenal gland size--an ultrasonographic study]."
|4.||Adrenal Cortex Neoplasms (Adrenocortical Cancer)
05/15/1993 - "These findings do not support the conclusion that adjuvant mitotane is beneficial in patients with localized or regional adrenocortical cancer. "
08/16/2012 - "In this study, we explored the molecular effect of mitotane on steroidogenesis in human adrenocortical cancer NCI-H295 cells. "
12/01/2008 - "Seventeen consecutive patients who were treated with mitotane after radical resection of adrenocortical cancer (ACC) from 1999 to 2005 underwent physical examination, routine laboratory evaluation, monitoring of mitotane concentrations, and a hormonal work-up at baseline and every 3 months till ACC relapse or study end (December 2007). "
11/01/2015 - "We report the case of toxic plasma levels with low doses of mitotane in a 47-year-old man with adrenocortical cancer. "
02/05/2015 - "These data demonstrate that RRM1 gene interferes with mitotane metabolism in adrenocortical cancer cells, as a possible mechanisms of drug resistance. "
|5.||Neoplasm Metastasis (Metastasis)
12/01/1992 - "Mitotane improved the survival rate only in patients with metastases who received it after operation (vs non-mitotane-treated patients [p < 0.05]). "
03/15/1981 - "He experienced an objective clinical remission and disappearance of pulmonary metastases while receiving o,p'-DDD as the sole chemotherapeutic agent. "
04/01/2012 - "Two months after surgery, she received radiation for suspected lumbar vertebral metastasis and initiated mitotane therapy. "
05/01/2011 - "No metastasis or size increase of the remaining adrenal glands were found suggesting that their hypermetabolic state could be attributed to mitotane treatment. "
06/01/2008 - "The second patient presented with an ACC of 9 cm. After resection, the patient developed liver metastases, which were treated with o,p'-DDD. "
|6.||Adrenocorticotropic Hormone (ACTH)
|8.||Etoposide (VP 16)
|1.||Drug Therapy (Chemotherapy)