|1.||Andrez, Jean-Christophe: 1 article (01/2009)|
|2.||Kohn, H: 1 article (10/2001)|
|3.||Na, Y: 1 article (10/2001)|
|4.||Nakanishi, Y: 1 article (10/2001)|
|5.||Bastow, K F: 1 article (10/2001)|
|6.||Li, V S: 1 article (10/2001)|
|7.||Amzel, L M: 1 article (06/2001)|
|8.||Cavelier, G: 1 article (06/2001)|
01/01/2009 - "Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. "
06/01/2001 - "Alternatively, in tumor cells QR can activate a number of cancer chemotherapeutic agents such as mitomycins and aziridylbenzoquinones. "
07/01/1991 - "Thus, the substantial differences in relative potencies of mitomycins are related not to the kind of tumor cell, but to the type of assay performed, cell culture versus whole animal. "
10/11/2001 - "When we compared the efficiency of DNA cross-linking for the dimeric mitomycins with their in vitro cytotoxicities in cultured human tumor cells, we observed a poor correlation. "
08/31/1999 - "These findings suggest potential therapeutic applications for MCRA in the treatment of cancer with the mitomycins and imply that intrinsic or selected mitomycin C resistance in mammalian cells may not be due solely to decreased bioactivation, as has been hypothesized previously, but instead could involve an MCRA-like mechanism."
01/01/1993 - "Several mitomycins were evaluated for their capacity to kill EMT6 cells and to produce DNA cross-links in both hypoxia and aeration. "
04/10/1998 - "Although this enzyme activates the mitomycins in vitro, its overexpression in living cells caused decreases in sensitivity to mitomycin C in air and decreases in sensitivity to porfiromycin under both air and hypoxia. "
|3.||Hepatocellular Carcinoma (Hepatoma)
|4.||Head and Neck Neoplasms (Head and Neck Cancer)
01/01/1995 - "The demonstration that mitomycin C and porfiromycin, used to kill the hypoxic fraction, in combination with irradiation, to eradicate the oxygenated portion of the tumor, produced enhanced cytodestructive effects on solid tumors in animals has led to the clinical evaluation of the mitomycins in combination with radiation therapy in patients with head and neck cancer. "
|2.||DNA (Deoxyribonucleic Acid)
|4.||NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)