HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Misonidazole

A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
Also Known As:
Ro 07-0582; Ro 7-0582; alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol; Ro 07 0582; Ro 070582; Ro 7 0582; Ro 70582; 1H-Imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-
Networked: 515 relevant articles (24 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Humm, John: 4 articles (09/2009 - 01/2004)
2. Mikiciuk-Olasik, Elżbieta: 3 articles (02/2014 - 01/2013)
3. Mallia, Madhava B: 2 articles (03/2015 - 03/2013)
4. Mathur, Anupam: 2 articles (03/2015 - 03/2013)
5. Banerjee, Sharmila: 2 articles (03/2015 - 03/2013)
6. Błaszczak-Świątkiewicz, Katarzyna: 2 articles (02/2014 - 01/2013)
7. Rischin, Danny: 2 articles (02/2014 - 05/2006)
8. Olszewska, Paulina: 2 articles (02/2014 - 01/2013)
9. Fisher, Richard: 2 articles (02/2014 - 05/2006)
10. Hicks, Rodney J: 2 articles (02/2014 - 05/2006)

Related Diseases

1. Neoplasms (Cancer)
08/01/1984 - "This implies that high LET killing is considerably more effective in this tumor system (hypoxic fraction of about 35%) than the hypoxic cell sensitization caused by misonidazole. "
09/01/1988 - "The major results were as follows: (1) patients who were old (70 to 80 years) fared as well as younger patients (P = 0.9198); (2) tumor site did not influence therapeutic outcome (P = 0.1100); (3) there was an insignificant difference in survival between patients with M0 and M1 disease (P = 0.7130); (4) radical surgery gave better survival; (5) misonidazole administered preoperatively was associated with worse survival (P = 0.0147); and (6) the histopathologic malignancy grading score system was very useful for prognostication--the tumor-host score in the operative specimen was the strongest of all analyzed predictive parameters. "
01/01/1987 - "Hydrogen-3-fluoromisonidazole diffused into tumors at a slower rate than misonidazole but it also cleared from normal tissues so that after 2 hr tumor-to-blood ratios favorable for imaging were achieved. "
10/01/1984 - "It was shown from this model that misonidazole should be effective for cancer which had a hypoxic fraction of more than 10%, and in which reoxygenation did hardly occur, and that the effect of misonidazole was not dependent on the size of dose per fraction for radioresistant cancer."
03/01/1984 - "These data suggest that misonidazole is effective in sensitizing hypoxic cells in the clinical dose range, and that it is directly cytotoxic to hypoxic tumor cells."
2. Carcinoma (Carcinomatosis)
3. Anoxia (Hypoxia)
4. Fever (Fevers)
5. Adenocarcinoma

Related Drugs and Biologics

1. Etanidazole
2. azomycin
3. Oxygen
4. 1- (2- nitro- 1- imidazolyl)- 3- aziridino- 2- propanol
5. Cisplatin (Platino)
6. fluoromisonidazole
7. Indomethacin (Indometacin)
8. Radiation-Sensitizing Agents
9. diethyl maleate
10. Hydralazine (Apresoline)

Related Therapies and Procedures

1. Radiotherapy
2. Drug Therapy (Chemotherapy)
3. Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
4. Ligation
5. Hemibody Irradiation