Mevinphos

01/01/1975 - "These results do not agree with those of an earlier study which decrements in VI performance of pigeons and squirrel monkeys appeared at low mevinphos doses which did not produce overt somatic signs of poisoning. "
08/01/1983 - "Rapid death by mevinphos poisoning while under observation."
01/01/1975 - "Performance in the DRL schedule was affected only at a dose of 0.30 mg/kg. No performance deficits or overt somatic signs of poisoning were present at mevinphos doses of 0.10 mg/kg or lower. "
01/01/1975 - "Mevinphos doses of 0.20 mg/kg and above produced observable somatic signs of poisoning and also produced dose-related decrements in performance in FR and VI tasks. "
01/01/1968 - "[Fatal, suicidal phosdrin poisoning]."

04/01/2005 - "Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat."
11/04/2009 - "Intravenous administration of lethal doses of mevinphos elicited an abrupt cardiac arrest, accompanied by elevated systemic arterial pressure and anoxia, augmented neuronal excitability and enhanced microvascular perfusion in RVLM. "

10/01/2020 - "Loss-of-function by immunoneutralization of DJ-1 in the RVLM significantly exacerbated those biochemical and cellular events, enhanced the progressive hypotension, diminished the increased and augmented the decreased spontaneous baroreflex-mediated sympathetic vasomotor tone respectively during Phases I and II, and heightened lethality during mevinphos intoxication. "
09/01/2017 - "Microinjection bilaterally of mevinphos (10 nmol) into the RVLM of anesthetized Sprague-Dawley rats induced a progressive hypotension and a decrease in baroreflex-mediated sympathetic vasomotor tone. "
01/01/2015 - "Immunoneutralization of FJL10540 in the RVLM significantly antagonized those biochemical changes, and blunted the progressive hypotension and the reduced baroreflex-mediated sympathetic vasomotor tone during mevinphos intoxication. "
01/01/2015 - "Microinjection bilaterally of mevinphos (10nmol) into the RVLM of anesthetized Sprague-Dawley rats induced a progressive hypotension that was accompanied by an increase (Phase I), followed by a decrease (Phase II) of an experimental index for baroreflex-mediated sympathetic vasomotor tone. "
03/01/2014 - "Microinjection of mevinphos (10 nmol) bilaterally into the RVLM of anesthetized Sprague-Dawley rats induced a progressive hypotension that was accompanied sequentially by an increase (Phase I) and a decrease (Phase II) of an experimental index for the baroreflex-mediated sympathetic vasomotor tone. "

01/01/2018 - "These results were based on a clinically relevant animal model that employs the pesticide mevinphos as the experimental insult in Sprague-Dawley rats to mimic brain stem death in patients died of organophosphate poisoning. "
05/01/2005 - "We evaluated the functional changes in the mitochondrial respiratory chain at the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic vasomotor tone, in an experimental model of fatal organophosphate poisoning using the insecticide mevinphos (Mev). "

03/01/1981 - "Evidence is given that the organo-phosphates mevinphos and malathion perturb the retinal functioning of the white mouse by acting 1. directly on the photoreceptors; 2. by a synaptolytic effect due to the inhibition of cholinesterases; 3. likely by a damage of the bipolar and/or the ganglion neurones."