|1.||Otte, Christian: 5 articles (04/2007 - 09/2003)|
|2.||Neylan, Thomas C: 4 articles (09/2014 - 09/2003)|
|3.||Tufik, Sergio: 4 articles (05/2013 - 04/2008)|
|4.||Yehuda, Rachel: 4 articles (10/2009 - 09/2003)|
|5.||Guerin, Glenn F: 3 articles (09/2014 - 01/2014)|
|6.||Goeders, Nicholas E: 3 articles (09/2014 - 01/2014)|
|7.||Schmoutz, Christopher D: 3 articles (09/2014 - 01/2014)|
|8.||Marek, J: 3 articles (07/2010 - 02/2001)|
|9.||Marmar, Charles R: 3 articles (04/2007 - 09/2003)|
|10.||Yassouridis, Alexander: 3 articles (10/2006 - 08/2004)|
02/01/2001 - "Metyrapone suppression of hypercortisolism currently represents the best treatment for these rare cases."
09/01/1993 - "Metyrapone therapy is effective in controlling the hypercortisolism in certain cases of Cushing's syndrome complicating pregnancy."
05/01/1981 - "Prolonged remission in florid Cushing's syndrome following metyrapone treatment."
11/01/2015 - "Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients."
01/01/2015 - "The baby girl underwent medical treatment of Cushing's syndrome with metyrapone which was followed by a rapid recovery. "
|2.||Post-Traumatic Stress Disorders (PTSD)
09/01/2003 - "Metyrapone caused an increase in awakenings and a marked decrease in quantitative measures of delta sleep that was significantly greater in controls compared to PTSD. "
07/01/2006 - "We present data from several studies examining the effect of metyrapone administration on the sleep EEG in PTSD and control subjects. "
08/01/2004 - "Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD."
09/01/2014 - "Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder."
10/01/2009 - "The metyrapone stimulation test was performed to further characterize hypothalamic-pituitary activity in Gulf War veterans (GWV) and its relationship to unexplained medical symptoms and post-traumatic stress disorder (PTSD). "
|3.||Pituitary Diseases (Disease, Anterior Pituitary)
03/01/1969 - "Studies of metyrapone responses in patients with pituitary disease."
01/01/2003 - "Abnormal responses should be considered diagnostic, while normal responses, especially in newly onset or recent pituitary disease, should be followed by either ITT or metyrapone test. "
08/01/2000 - "The overnight metyrapone test was performed only in the subjects with pituitary disease. "
11/01/1964 - "METHOPYRAPONE TESTS IN HYPOTHALAMIC-PITUITARY DISEASE."
08/01/2000 - "The 65 patients with pituitary disease were categorized according to the 11-deoxycortisol response to metyrapone as follows: 53 normal (11-deoxycortisol > 200 nmol/l) and 12 subnormal (< 200 nmol/l). "
07/01/2011 - "Here we demonstrate that metyrapone affords dose-dependent protection against 6-Hz seizures 30 min after injection (ED(50), 191 mg/kg), but is markedly more potent at 6 h (ED(50), 30 mg/kg). "
01/01/1998 - "How does metyrapone decrease seizures?"
07/01/1996 - "Seizure-induced damage to hippocampal pyramidal neurons (assessed by cell counts and immunochemical analyses of cytoskeletal alterations) was significantly reduced in rats administered metyrapone. "
11/08/1988 - "Thus, metyrapone, which is used safely and efficaciously in other clinical contexts, might prove protective of the brain following seizure in the human."
11/08/1988 - "Metyrapone did not change the intensity of seizures, but rather, apparently, changed the capacity of neurons to withstand the seizure. "
12/01/2012 - "However, metyrapone injection did not influence the protective effect of CRF on the gastric mucosa against ischemia-reperfusion-induced lesion. "
06/04/1999 - "Transient forebrain ischemia was induced in gerbils, and the effect of a pre-ischemic treatment with metyrapone (100 mg/kg) on delayed neuronal death in hippocampal CA1 neurons was evaluated. "
04/01/2011 - "The single dose of metyrapone attenuated the ischemia-induced adrenocortical hyper-responsiveness and subsequent memory deficits despite not providing neuroprotection in the hippocampal CA1 pyramidal cells. "
10/01/1999 - "Metyrapone, but none of the other compounds, attenuated the occurrence of seizures immediately after ischemia. "
06/04/1999 - "The metyrapone treatment morphologically improved the damage provoked by 3 min of ischemia, although it did not alleviate the damage by 5 min. Ischemia for 3 min produced a 306% increase in the glutamate concentration in perfusates, and metyrapone suppressed the peak value to 42% of that in the control group. "
|1.||Adrenocorticotropic Hormone (ACTH)
|3.||Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
|9.||Mifepristone (RU 486)
|2.||Drug Therapy (Chemotherapy)