|1.||Herrmann, Wolfgang: 10 articles (03/2013 - 01/2002)|
|2.||Obeid, Rima: 9 articles (01/2015 - 07/2003)|
|3.||Stabler, Sally P: 5 articles (01/2012 - 05/2002)|
|4.||Allen, Robert H: 5 articles (01/2012 - 05/2002)|
|5.||Schorr, Heike: 5 articles (01/2008 - 07/2003)|
|6.||Mello, Carlos Fernando: 5 articles (08/2005 - 04/2003)|
|7.||Steiner, Jörg M: 4 articles (03/2015 - 01/2012)|
|8.||Suchodolski, Jan S: 4 articles (03/2015 - 01/2012)|
|9.||de Groot, Lisette C P G M: 4 articles (03/2014 - 05/2005)|
|10.||Green, Ralph: 4 articles (12/2009 - 08/2004)|
|1.||Vitamin B 12 Deficiency (Vitamin B12 Deficiency)
12/01/2015 - "Seventeen vegan or vegetarian adults (26-57 years of age) with a known vitamin B12 deficiency, as evidenced by a baseline serum methylmalonic acid (MMA) level above 270 nmol/L at screening, but who otherwise appeared healthy were enrolled in the study. "
03/01/2012 - "Methylmalonic acid (MMA) is considered as the most representative indicator of metabolic vitamin B(12) deficiency and is used as such in this study. "
01/01/2008 - "Recent studies have not investigated functional markers of vitamin B12 deficiency, such as methylmalonic acid. "
05/01/1987 - "If the high sensitivity and specificity of the gas chromatography-mass spectrometry assay for urinary methylmalonic acid is supported by other clinical studies, the methylmalonic acid assay may become the reference standard for the diagnosis of vitamin B12 deficiency."
01/01/1971 - "Clinical aspect of the studies of metabolic precursors of methylmalonic acid in vitamin B 12 deficiency."
|2.||Metabolic Diseases (Metabolic Disease)
05/01/1986 - "These studies support the efficacy of hydroxocobalamin therapy in this disease, suggest that methylmalonic acid may be the most appropriate metabolite to monitor for therapeutic response, and in importance of electrophysiologic studies in character in objectively monitoring the response to treatment metabolic disease."
01/01/1991 - "Organic acids have been determined in aqueous humour and plasma by gas chromatography-mass spectrometry in 38 cases of infant death and 4 cases of inherited metabolic disease: one had a complex fatty-acid oxidation disorder with a large urinary excretion of adipic acid, the others had a disorder of propionate catabolism with a large urinary excretion of methylmalonic acid. "
08/01/2003 - "Hyperammonemia is a common finding in children with methylmalonic acidemia, an inherited metabolic disease characterized by mental retardation, convulsions, and accumulation of methylmalonic acid (MMA). "
08/01/1982 - "Methylmalonic acidemia, an inherited metabolic disease affecting the catabolism of propionic acid, is manifested by persistent metabolic acidosis, urinary excretion of large amounts of methylmalonic acid, and occasionally by hypoglycemia. "
04/16/2003 - "Two patients, one male and one female, were seen to have psychomotor retardation, erratic attacks of myoclonic convulsions, hypsarrhythmic encephalographic pattern and an increase in the urinary excretion of methylmalonic acid, as shown by gas chromatography and mass spectrometry, all of which supported a diagnosis of MMA in both cases. "
05/20/1996 - "Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms."
06/08/2007 - "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures. "
03/11/2005 - "Acute intrastriatal administration of methylmalonic acid (MMA) induces convulsions through NMDA receptor-mediated mechanisms and increases production of end products of oxidative damage. "
04/01/2003 - "GM1 ganglioside attenuates convulsions and thiobarbituric acid reactive substances production induced by the intrastriatal injection of methylmalonic acid."
03/01/1991 - "We suggest that some of the described neuropathological findings are an immediate consequence of a disturbed methylmalonic acid metabolism starting in utero, and not exclusively a secondary phenomenon due to accumulation of metabolites and acidosis postpartum."
01/01/1971 - "[A case of methylmalonic acid acidosis]."
07/01/1987 - "Methylmalonic acid, methanol, metabolic acidosis, and lesions of the basal ganglia."
08/01/2004 - "The laboratory findings showed metabolic acidosis in 6 cases, hyperammonemia in 5 cases, ketonuria in 4 cases and remarkable elevation of urinary methylmalonic acid concentration in all cases. "
09/30/2003 - "Urine from treated rats was more acidic throughout the study and urinary methylmalonic acid and plasma N-methyltetrahydrofolate concentrations were increased, indicating an acidosis, vitamin B12 deficiency and impaired folate metabolism, respectively. "
08/01/2011 - "Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid."
06/01/1993 - "Serum cobalamin and methylmalonic acid in Alzheimer dementia."
01/01/2013 - "Although dose-response evidence on sensitive markers of vitamin B12 status (methylmalonic acid and holotranscobalamin) was scarce, 4 of 5 cohort studies reported significant associations with risk of dementia, Alzheimer's disease, or global cognition. "
12/14/2012 - "However, four studies that used newer biomarkers of vitamin B₁₂ status (methylmalonic acid and holotranscobalamin (holoTC)) showed associations between poor vitamin B₁₂ status and the increased risk of cognitive decline or dementia diagnosis. "
12/01/2006 - "An elevated blood concentration of homocysteine is an established risk factor for cognitive impairment and dementia, but associations between cognition and methylmalonic acid (MMA), a related metabolic marker of vitamin B-12 deficiency, are less clear. "
|3.||Vitamin B 12 (Cyanocobalamin)
|5.||Folic Acid (Vitamin M)
|7.||Biological Markers (Surrogate Marker)
|1.||Transplantation (Transplant Recipients)
|3.||Renal Dialysis (Hemodialysis)