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Methylenetetrahydrofolate Dehydrogenase (NADP) (Dehydrogenase, Methylenetetrahydrofolate)

An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Also Known As:
Dehydrogenase, Methylenetetrahydrofolate; Methylenetetrahydrofolate Dehydrogenase; Methylenetetrahydrofolate Dehydrogenase (NADP+); 5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase
Networked: 33 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Mills, James L: 3 articles (04/2009 - 11/2002)
2. Brody, Lawrence C: 3 articles (04/2009 - 11/2002)
3. Gilbert, John R: 2 articles (06/2011 - 10/2006)
4. Kirke, Peadar N: 2 articles (04/2009 - 11/2002)
5. Pangilinan, Faith: 2 articles (04/2009 - 07/2005)
6. Molloy, Anne M: 2 articles (04/2009 - 11/2002)
7. Scott, John M: 2 articles (04/2009 - 11/2002)
8. Parle-McDermott, Anne: 2 articles (04/2009 - 11/2002)
9. Cox, Christopher: 2 articles (07/2005 - 11/2002)
10. Bertino, Joseph R: 1 article (10/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
3. Neoplasm Metastasis (Metastasis)
4. Down Syndrome (Down's Syndrome)
5. Atherosclerosis

Related Drugs and Biologics

1. Thymidylate Synthase
2. Messenger RNA (mRNA)
3. Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
4. 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
5. methionine synthase reductase
6. Folic Acid (Vitamin M)
7. Methenyltetrahydrofolate Cyclohydrolase
8. Formate-Tetrahydrofolate Ligase
9. Reduced Folate Carrier Protein
10. Transcobalamins (Transcobalamin II)