|1.||Kumagai, Shinji: 3 articles (01/2015 - 07/2013)|
|2.||Xia, Yan: 3 articles (11/2014 - 04/2014)|
|3.||Zuo, Jian: 3 articles (11/2014 - 04/2014)|
|4.||Li, Xiang: 3 articles (11/2014 - 04/2014)|
|5.||Moshi, Mainen J: 3 articles (01/2014 - 01/2006)|
|6.||Nondo, Ramadhani S O: 3 articles (01/2014 - 01/2006)|
|7.||Houghton, P J: 3 articles (03/2010 - 12/2000)|
|8.||Marino, Dale J: 3 articles (12/2007 - 06/2006)|
|9.||Ferraro, G: 3 articles (01/2005 - 09/2002)|
|10.||Tan, P V: 3 articles (08/2001 - 12/2000)|
01/01/2006 - "From these results, it is believed that further reductions in dichloromethane emissions from industrial factories on a prefectural or a nationwide scale would not be effective in reducing cancer risk. "
10/01/1999 - "The usefulness of additional cohort studies for the evaluation of cancer risks associated with methylene chloride exposure will depend largely on whether the relevant exposure period has passed and whether exposure characterization (e.g., peak or intermittent exposure or intensity) can be improved."
11/01/2006 - "In the present study, we investigated the effect of a dichloromethane (DCM) fraction of V. scorpioides leaf extract on Ehrlich ascitic and solid tumor-bearing mice. "
09/01/2004 - "In this study, the methylene chloride fraction of Spatholobi Caulis (MCSC) was examined to determine if it possesses anti-cancer activity via its apoptosis-inducing activity. "
10/01/1999 - "Although these studies collectively cannot rule out the possibility of any cancer risk associated with methylene chloride exposure, they do support a conclusion of no substantive cancer risk. "
01/01/2012 - "In the present study, the anticancer efficacy of dichloromethane extracts of Lycoris aurea (DELA), was evaluated both in vivo and in vitro using murine sarcoma 180 cells. "
06/01/2011 - "IC50 value of dichloromethane fraction was 94.2 μg/ml against sarcoma 180 cells lower than any other solvent fractions. "
06/01/2011 - "The objective of this study was to evaluate and compare the antitumor activity of different solvent fractions (ethanol, dichloromethane, ethyl acetate, butanol and water) of the Auricularia auricula-judae 70% ethanol extract on the P388D1 macrophage and sarcoma 180 cells. "
|3.||Breast Neoplasms (Breast Cancer)
05/15/2011 - "In this study, we report on the methylene chloride fraction from SC exerting cytotoxicity against prostate and breast cancer cells in a dose-dependent manner. "
01/01/2015 - "We investigated cytotoxic effects of dichloromethane fractions of Scrophularia oxysepala extract on the MCF-7 breast cancer cell line. "
01/01/2015 - "Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells."
01/01/2014 - "Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. "
01/01/2015 - "Cytotoxicity assay of mother extract and its fractions over breast cancer and cervix cancer cell lines showed that dichloromethane (DCM) fraction was most cytotoxic (IC50 36.0-51.0 µg mL(-1) at 72 h). "
|4.||Body Weight (Weight, Body)
07/01/2006 - "In a preliminary 6 week-study, experimental groups (n=9/group) received either the vehicle or a methylene chloride extract (2500 mg/kg body weight) where potential non-polar hepatotoxin(s) could be concentrated. "
06/01/1990 - "In recent pharmacokinetically based risk assessments for methylene chloride, Andersen et al. argued that total reactive metabolite (TRM) divided liver weight was the proper measure of dose to target tissue, while the EPA argued that TRM divided by body weight to the two-thirds power was more appropriate. "
09/01/1986 - "In order to evaluate its toxicity and carcinogenic potential, dichloromethane (DCM) at levels of 0, 0, 5, 50, 125 and 250 mg/kg body weight/day was administered in deionized water to a total of 500 Fischer 344 rats of each sex for 104 wk. An additional group received a level of 250 mg/kg body weight/day for 78 wk followed by a 26-wk recovery period during which only deionized water was presented. "
09/01/1986 - "To investigate its carcinogenic potential, dichloromethane (DCM) was administered at levels of 0, 0, 60, 125, 185 and 250 mg/kg body weight/day to a total of 1000 B6C3F1 mice in deionized drinking-water for 104 wk. The high-dose male and female mice showed a transitory increase in mean leucocyte counts. "
12/01/2014 - "Our results showed the dichloromethane gradient fraction was most effective, significantly (P < 0.05) suppressing infection by 99.46% at 100 mg/kg body weight. "
|5.||Pancreatic Neoplasms (Pancreatic Cancer)
06/22/2012 - "In this study, it was found that a dichloromethane extract of the stem of Uvaria dac preferentially inhibited PANC-1 human pancreatic cancer cells survival under nutrition-deprived conditions at a concentration of 10 μg/mL. Workup of this bioactive extract led to the discovery of (+)-grandifloracin (8) as a potent antiausterity agent as evaluated in a panel of four human pancreatic cancer cell lines, PANC-1 (PC(50), 14.5 μM), PSN-1 (PC(50), 32.6 μM), MIA PaCa-2 (PC(50), 17.5 μM), and KLM-1 (32.7 μM). "
06/01/1988 - "Methylene chloride and cancer of the pancreas."
05/01/1997 - "An excess risk of liver and biliary tract cancers was suggested in the cohort with the high exposure to methylene chloride, but not found in the other cohorts where an excess risk of pancreatic cancer was suggested. "
07/01/1997 - "Also, to investigate patterns of mortality after exposure to methylene chloride; in particular, mortality from liver and biliary tract cancer, lung cancer, pancreatic cancer, and cardiovascular disease. "
01/01/2011 - "In this work, rohituka and chittagonga, fractionated with petroleum ether, dichloromethane, and ethanol, were explored for their anticancer potential against two breast cancer (MCF-7 and HTB-126) and three pancreatic cancer (Panc-1, Mia-Paca2, and Capan1). "
|2.||Ethanol (Ethyl Alcohol)
|2.||Drug Therapy (Chemotherapy)
|3.||Traditional Medicine (Folk Remedies)