Methoxydimethyltryptamines (Methoxydimethyltryptamine)

Compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups. Members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains. They are possibly involved in the etiology of schizophrenia.

Also Known As:

Methoxydimethyltryptamine; 5 Methoxy N,N Dimethyltryptamine; 5-Methoxy-N,N-Dimethyltryptamine; N,N-Dimethyl-5-Methoxytryptamine; N,N Dimethyl 5 Methoxytryptamine; Methylbufotenin

Networked: 37 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Amoroso, Timothy: 1 article (01/2020)
2.	Averill, Lynnette A: 1 article (01/2020)
3.	Barsuglia, Joseph P: 1 article (01/2020)
4.	Davis, Alan K: 1 article (01/2020)
5.	Sepeda, Nathan D: 1 article (01/2020)
6.	Jiang, Xi-Ling: 1 article (09/2016)
7.	Mager, Donald E: 1 article (09/2016)
8.	Schmidt, Stephan: 1 article (09/2016)
9.	Shen, Hong-Wu: 1 article (09/2016)
10.	Yu, Ai-Ming: 1 article (09/2016)

Related Diseases

1.	Treatment-Resistant Depressive Disorder 01/01/2023 - "A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression."
2.	Wounds and Injuries (Trauma) 09/03/2023 - ": Data were collected from an ibogaine and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) clinical treatment program for SOFV with a history of trauma exposure. " 01/01/2020 - "Therefore, this study examined psychedelic treatment with ibogaine and 5-methoxy-N,N-dimethyltryptamine for trauma-related psychological and cognitive impairment among U.S. "
3.	Cognitive Dysfunction 01/01/2020 - "Therefore, this study examined psychedelic treatment with ibogaine and 5-methoxy-N,N-dimethyltryptamine for trauma-related psychological and cognitive impairment among U.S. "
4.	Tremor (Tremors) 11/01/1989 - "Following an IP injection of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), rats exposed to the stress for 10 days, but not for 5 days, displayed enhanced forepaw treading, tremor and Straub tail compared to control rats. " 12/29/1995 - "Adult rats were studied for serotonin and its metabolite in basal ganglia, nociceptive responses to electric current and tremor induced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) to assess the effects of a single systemic injection of serotonin antiserum given at 1 day old. " 10/14/1985 - "Postsynaptic changes appear to be involved as responses to the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 5 mg/kg i.p.) (tremor, hind-limb abduction and forepaw treading) were also decreased. " 01/01/1985 - "The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). " 03/25/1985 - "Some responses to the 5-HT releaser p-chloroamphetamine (PCA) (4 and 10 mg/kg, i.p.) and the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine (5-MEODMT) (5 mg/kg, i.p.) (forepaw treading and tremor) were enhanced after 7 days immobilization but others (limb abduction and headweaving) were not. "
5.	Shock 02/12/1986 - "5-Methoxy-N,N-dimethyltryptamine (1 mg/kg) potentiated shock-induced antinociception and this potentiation was also antagonized by decreased NA neurotransmission. " 01/01/1988 - "Intrathecal administration of 6-hydroxydopamine (6-OHDA) abolished the antinociceptive effects of acute administration of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 1 mg/kg, s.c.) in the hot-plate, tail-flick and shock titration tests of nociception. " 07/01/1978 - "Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). " 07/01/1978 - "Effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats." 04/29/1985 - "The acute effects of the 5-hydroxytryptamine agonist, 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), upon pain sensitivity, using shock titration, tail-flick and hot-plate methods, in noradrenaline- and 5-hydroxytryptamine-depleted rats were examined. "

Related Drugs and Biologics

1.	Hallucinogens (Psychedelics)
2.	Ibogaine (Endabuse)
3.	Serotonin (5 Hydroxytryptamine)
4.	Serotonin Receptor Agonists (Serotonin Receptor Agonist)
5.	N,N-Dimethyltryptamine (Dimethyltryptamine)
6.	Tryptophan (L-Tryptophan)
7.	Monoamine Oxidase (MAO)
8.	Lysergic Acid Diethylamide (LSD)
9.	Bufotenin (Mappin)
10.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Injections
3.	Analgesia
4.	Aftercare (After-Treatment)