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Methoxychlor (Metox)

An insecticide. Methoxychlor has estrogenic effects in mammals, among other effects.
Also Known As:
Metox; DMDT; Trichloroethane, Dianisyl; Dianisyl Trichloroethane; Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxy)-
Networked: 58 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Mathur, P P: 6 articles (04/2010 - 03/2002)
2. Tajima, Y: 3 articles (07/2013 - 03/2011)
3. Fukuyama, T: 3 articles (07/2013 - 03/2011)
4. Kosaka, T: 3 articles (07/2013 - 03/2011)
5. Saradha, B: 3 articles (04/2010 - 11/2008)
6. Vaithinathan, S: 3 articles (04/2010 - 11/2008)
7. Latchoumycandane, C: 3 articles (12/2002 - 03/2002)
8. Kuo, Chun-Chi: 2 articles (02/2015 - 05/2011)
9. Liang, Wei-Zhe: 2 articles (02/2015 - 05/2011)
10. Chou, Chiang-Ting: 2 articles (02/2015 - 05/2011)

Related Diseases

1. Body Weight (Weight, Body)
2. Neoplasms (Cancer)
3. Atrophy
4. Breast Neoplasms (Breast Cancer)
05/01/2012 - "Treatment with bisphenol A and methoxychlor results in the growth of human breast cancer cells and alteration of the expression of cell cycle-related genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway."
01/01/2006 - "With respect to pesticides, breast cancer was positively associated with pounds of the organochlorines methoxychlor (adjusted incidence rate ratio [IRR] for highest quartile = 1.18; confidence interval [CI] = 1.03-1.35) and toxaphene (IRR = 1.16; CI = 1.01-1.34). "
10/02/2002 - "Five natural, pharmaceutical, or xenobiotic chemicals [17beta-estradiol (E2), ethynylestradiol (EE2), diethystilbestrol (DES), methoxychlor (MXC), nonylphenol (NP)] were tested in two in vitro assays [yeast estrogen screen (YES), MCF-7 breast tumor cell proliferation (E-Screen)], and compared with previously reported results from two in vivo male sheepshead minnow vitellogenin (VTG) production studies. "
11/01/2003 - "A group of planar (estradiol, genistein, and coumestrol) and nonplanar (methoxychlor and its mono- and didemethylated phenolic metabolites) environmental estrogens, which are all full estrogens in MCF-7 breast cancer cell proliferation assays, was shown to segregate discretely into planar and nonplanar groups. "
11/01/2001 - "The effects of simultaneous administration of some binary mixtures of seven natural and synthetic oestrogenic substances (17beta-estradiol, estrone, bisphenol A, butylbenzyl phthalate, endosulfan, methoxychlor and pentachlorophenol) on the cellular proliferation of human breast cancer MCF-7 cells in-vitro (a modified E-screen assay) have been measured. "
5. Inflammation

Related Drugs and Biologics

1. Estrogens (Estrogen)
2. Estradiol (Estrace)
3. bisphenol A
4. Parathion (Ethyl Parathion)
5. Insecticides
6. Toxaphene
7. Piperonyl Butoxide
8. Lindane (gamma-Hexachlorocyclohexane)
9. Fura-2 (Fura 2)
10. 9,10-Dimethyl-1,2-benzanthracene (DMBA)

Related Therapies and Procedures

1. Intraperitoneal Injections
2. Drug Therapy (Chemotherapy)