|1.||Kim, Sunghoon: 4 articles (09/2015 - 08/2004)|
|2.||Gillespie, J Robert: 3 articles (10/2012 - 05/2011)|
|3.||Shibata, Sayaka: 3 articles (10/2012 - 05/2011)|
|4.||Fan, Erkang: 3 articles (10/2012 - 05/2011)|
|5.||Buckner, Frederick S: 3 articles (10/2012 - 05/2011)|
|6.||Verlinde, Christophe L M J: 3 articles (10/2012 - 05/2011)|
|7.||Hol, Wim G J: 3 articles (10/2012 - 05/2011)|
|8.||Kang, Taehee: 2 articles (09/2015 - 12/2011)|
|9.||Kwon, Nam Hoon: 2 articles (09/2015 - 12/2011)|
|10.||Kim, Jessica E: 2 articles (10/2012 - 07/2012)|
05/01/2011 - "Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice."
05/01/2009 - "The aim of this study was to characterize the antimicrobial profile of REP3123, a novel inhibitor of methionyl-tRNA synthetase (MetRS) in development for the treatment of Clostridium difficile infection. "
05/01/2009 - "REP3123 is a fully synthetic methionyl-tRNA synthetase inhibitor in pre-clinical development as a novel agent to treat Clostridium difficile infection (CDI). "
09/28/2015 - "Elevated activity of methionyl-tRNA synthetase (MRS) in many cancers renders it a possible drug target in this disease area, as well as in a series of parasitic diseases. "
09/28/2015 - "Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis."
12/06/2011 - "Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3."
05/16/2008 - "Although AIMP3/p18 is normally associated with the multi-tRNA synthetase complex via its specific interaction with methionyl-tRNA synthetase, it also works as a tumor suppressor by interacting with ATM, the upstream kinase of p53. "
|3.||African Trypanosomiasis (Nagana)
07/26/2012 - "Urea-based methionyl-tRNA synthetase inhibitors were designed, synthesized, and evaluated for their potential toward treating human African trypanosomiasis (HAT). "
10/10/2012 - "To guide development of new drugs targeting methionyl-tRNA synthetase (MetRS) for treatment of human African trypanosomiasis, crystal structure determinations of Trypanosoma brucei MetRS in complex with its substrate methionine and its intermediate product methionyl-adenylate were followed by those of the enzyme in complex with high-affinity aminoquinolone inhibitors via soaking experiments. "
07/01/2011 - "The more reactive conformation is the homocysteine thiolactone (HcyT), product to the nonspecific action of methionyl-tRNA synthetase, which is incorporated into proteins by disulfide bonds (S-homocysteinilation) or amide bonds (N-homocysteinilation) affecting protein structure and function leading to cell toxicity, autoimmune responses and atherogenesis. "
|5.||Vascular Diseases (Vascular Disease)
|2.||Proteins (Proteins, Gene)
|4.||Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
|6.||Complementary DNA (cDNA)
|8.||Transfer RNA (tRNA)