Methionine-tRNA Ligase

An enzyme that activates methionine with its specific transfer RNA. EC 6.1.1.10.

Also Known As:

Met-tRNA Ligase; Methionyl-tRNA Synthetase; Ligase, Met-tRNA; Ligase, Methionine-tRNA; Met tRNA Ligase; Methionine tRNA Ligase; Methionyl tRNA Synthetase; Synthetase, Methionyl-tRNA; Methionyl T RNA Synthetase; L-Methionine:tRNA(Met) ligase (AMP-forming)

Networked: 43 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        Methionine-tRNA Ligase: 43
        human MARS1 protein

Experts

1.	Kim, Sunghoon: 8 articles (10/2021 - 08/2004)
2.	Buckner, Frederick S: 8 articles (01/2020 - 05/2011)
3.	Fan, Erkang: 8 articles (01/2020 - 05/2011)
4.	Ranade, Ranae M: 7 articles (01/2020 - 07/2012)
5.	Kwon, Nam Hoon: 6 articles (10/2021 - 12/2011)
6.	Gillespie, J Robert: 6 articles (01/2020 - 05/2011)
7.	Zhang, Zhongsheng: 6 articles (01/2020 - 05/2011)
8.	Chang, Yoon Soo: 5 articles (10/2021 - 07/2017)
9.	Hol, Wim G J: 5 articles (01/2019 - 05/2011)
10.	Shibata, Sayaka: 5 articles (01/2019 - 05/2011)

Related Diseases

1.	Myocardial Infarction 01/01/2019 - "Our objective was to examine Hcy-thiolactone, a chemically reactive metabolite generated by methionyl-tRNA synthetase and cleared by the kidney, as a risk predictor of incident acute myocardial infarction (AMI) in the Western Norway B-Vitamin Intervention Trial. "
2.	Neoplasms (Cancer) 09/28/2015 - "Elevated activity of methionyl-tRNA synthetase (MRS) in many cancers renders it a possible drug target in this disease area, as well as in a series of parasitic diseases. " 07/05/2017 - "Methionyl-tRNA synthetase (MRS) plays a critical role in initiating translation by transferring Met to the initiator tRNA (tRNAiMet) and protection against ROS-mediated damage, suggesting that its overexpression is related to cancer growth and drug resistance. " 11/14/2023 - "We evaluated the ability of the expression level of methionyl-tRNA synthetase 1 (MARS1)-which facilitates cancer growth by modulating protein synthesis and the cell cycle-to predict the prognosis of PDAC. " 10/01/2021 - "Methionyl-tRNA synthetase 2 (Mars2) has been suggested as a biomarker indicating poor prognosis of cancers. " 09/14/2018 - "Stabilization of Cyclin-Dependent Kinase 4 by Methionyl-tRNA Synthetase in p16INK4a-Negative Cancer."
3.	Clostridium Infections 05/01/2009 - "The aim of this study was to characterize the antimicrobial profile of REP3123, a novel inhibitor of methionyl-tRNA synthetase (MetRS) in development for the treatment of Clostridium difficile infection. " 05/01/2009 - "REP3123 is a fully synthetic methionyl-tRNA synthetase inhibitor in pre-clinical development as a novel agent to treat Clostridium difficile infection (CDI). "
4.	Pulmonary Alveolar Proteinosis 02/01/2019 - "Methionyl-tRNA synthetase novel mutation causes pulmonary alveolar proteinosis." 01/01/2018 - "Mutations in MARS identified in a specific type of pulmonary alveolar proteinosis alter methionyl-tRNA synthetase activity." 05/07/2015 - "Biallelic Mutations of Methionyl-tRNA Synthetase Cause a Specific Type of Pulmonary Alveolar Proteinosis Prevalent on Réunion Island." 11/01/2021 - "Pulmonary alveolar proteinosis can be caused by mutation in the methionyl-tRNA synthetase (MARS) gene while mutations in the leucine-tRNA synthetase (LARS) gene lead to infantile liver failure syndrome type 1. We report the case of a patient with LARS1 pathogenics variants and two patients with MARS1 pathogenics variants. "
5.	Brucellosis (Malta Fever) 01/01/2017 - "The Brucella melitensis methionyl-tRNA-synthetase (MetRSBm) is a promising target for brucellosis drug development. " 01/01/2016 - "We investigated Brucella melitensis methionyl-tRNA-synthetase (BmMetRS) with molecular, structural and phenotypic methods to learn if BmMetRS is a promising target for brucellosis drug development. " 01/01/2016 - "Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis." 01/01/2016 - "Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis." 01/01/2022 - "However, Strophanthidin formed 3 hydrogen bonds with the target at ILE21, GLY262 and LEU294, and induced a total RMSF of 5.4541 at Pocket 1. Overall, Isopteropodin and Strophanthidin were found to be better drug candidates than OOU and they showed potentials to inhibit the Brucella melitensis Methionyl-tRNA synthetase at Pocket 1, hence abilities to treat brucellosis. "

Related Drugs and Biologics

1.	homocysteine thiolactone
2.	Vitamin B Complex (B Vitamins)
3.	Met Transfer RNA
4.	REP 3123
5.	Proteins (Proteins, Gene)
6.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
7.	Methionine (L-Methionine)
8.	Biomarkers (Surrogate Marker)
9.	Transfer RNA (tRNA)
10.	Methionine-tRNA Ligase