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Methionine Adenosyltransferase

An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6.
Also Known As:
ATP-Methionine S-Adenosyltransferase; ATP Methionine S Adenosyltransferase; Adenosyltransferase, Methionine; S Adenosylmethionine Synthetase; S-Adenosyltransferase, ATP-Methionine; Synthetase, S-Adenosylmethionine; S-Adenosylmethionine Synthetase; ATP:L-methionine S-adenosyltransferase
Networked: 187 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lu, Shelly C: 27 articles (01/2022 - 08/2002)
2. Mato, José M: 23 articles (01/2021 - 08/2002)
3. Yang, Heping: 13 articles (01/2021 - 07/2007)
4. Li, Tony W H: 9 articles (01/2021 - 12/2010)
5. Peng, Hui: 7 articles (01/2022 - 01/2013)
6. Ramani, Komal: 6 articles (01/2022 - 01/2008)
7. Mato, Jose M: 5 articles (01/2022 - 04/2008)
8. Tomasi, Maria Lauda: 5 articles (01/2021 - 12/2010)
9. Corrales, Fernando J: 5 articles (06/2012 - 08/2002)
10. Fan, Wei: 4 articles (01/2022 - 01/2016)

Related Diseases

1. Hypoxia (Hypoxemia)
2. Neoplasms (Cancer)
3. Homocystinuria
4. Hypermethioninemia
5. Non-alcoholic Fatty Liver Disease
11/01/2010 - "Mice lacking the methionine adenosyltransferase (MAT) gene MAT1A exhibit a chronic reduction in hepatic S-adenosylmethionine (SAMe) levels, basal activation of LKB1, and spontaneous development of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). "
01/01/2021 - "We applied this technique to define the metabolic landscape in livers from a mouse model of the rare disease disorder congenital erythropoietic porphyria (CEP) as well as two well-known murine models of nonalcoholic steatohepatitis: one genetic, methionine adenosyltransferase 1A knockout mice, and the other dietary, mice fed a high-fat choline-deficient diet. "
01/01/2022 - "Four candidate genes, including LPA (lipoprotein A), IGFBP-1 (insulin-like growth factor-binding protein 1), SERPINF2 (serpin family F member 2) and MAT1A (methionine adenosyltransferase 1A), were differentially expressed in moderate/advanced NAFLD, which was confirmed in three independent RNA sequencing datasets from large, publicly available NAFLD studies. "
06/01/2013 - "To examine the role of one-carbon metabolism dysregulation in the pathogenesis and individual susceptibility to NAFLD, we used a "population-based" mouse model where male mice from 7 inbred were fed a choline- and folate-deficient (CFD) diet for 12 wk. Strain-dependent down-regulation of several key one-carbon metabolism genes, including methionine adenosyltransferase 1α (Mat1a), cystathionine-β-synthase (Cbs), methylenetetrahydrofolate reductase (Mthfr), adenosyl-homocysteinase (Ahcy), and methylenetetrahydrofolate dehydrogenase 1 (Mthfd1), was observed. "
01/01/2021 - "We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH) microarray data and microarray/RNA-seq data from various mouse models of nonalcoholic fatty liver disease NASH/NAFLD with total 4249 genes examined and made the following findings: (i) human NASH and NAFLD mouse models upregulate both cytokines and chemokines; (ii) pathway analysis indicated that human NASH can be classified into metabolic and immune NASH; methionine- and choline-deficient (MCD)+high-fat diet (HFD), glycine N-methyltransferase deficient (GNMT-KO), methionine adenosyltransferase 1A deficient (MAT1A-KO), and HFCD (high-fat-cholesterol diet) can be classified into inflammatory, SAM accumulation, cholesterol/mevalonate, and LXR/RXR-fatty acid β-oxidation NAFLD, respectively; (iii) canonical and noncanonical inflammasomes play differential roles in the pathogenesis of NASH/NAFLD; (iv) trained immunity (TI) enzymes are significantly upregulated in NASH/NAFLD; HFCD upregulates TI enzymes more than cytokines, chemokines, and inflammasome regulators; (v) the MCD+HFD is a model with the upregulation of proinflammatory cytokines and canonical and noncanonical inflammasomes; however, the HFCD is a model with upregulation of TI enzymes and lipid peroxidation enzymes; and (vi) caspase-11 and caspase-1 act as upstream master regulators, which partially upregulate the expressions of cytokines, chemokines, canonical and noncanonical inflammasome pathway regulators, TI enzymes, and lipid peroxidation enzymes. "

Related Drugs and Biologics

1. S-Adenosylmethionine (Ademetionine)
2. Methionine (L-Methionine)
3. Cystathionine
4. Messenger RNA (mRNA)
5. Adenosine Triphosphate (ATP)
6. RNA (Ribonucleic Acid)
7. Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
8. Folic Acid (Vitamin M)
9. DNA (Deoxyribonucleic Acid)
10. Carbon

Related Therapies and Procedures

1. Transplantation
2. Chemoprevention
3. Therapeutics
4. Nephrectomy
5. Drug Therapy (Chemotherapy)