Methaqualone (Quaalude)

A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Also Known As:

Networked: 76 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Plüddemann, Andreas: 3 articles (06/2005 - 08/2002)
2.	Parry, Charles D H: 2 articles (06/2005 - 08/2002)
3.	Archer, Edward: 1 article (12/2021)
4.	Brocker, Ludwig: 1 article (12/2021)
5.	Volschenk, Mercia: 1 article (12/2021)
6.	Wolfaardt, Gideon M: 1 article (12/2021)
7.	Fitzgerald, Robert L: 1 article (09/2021)
8.	Kreshak, Allyson A: 1 article (09/2021)
9.	Lund, Kyle: 1 article (09/2021)
10.	Schwartz, Kristy: 1 article (09/2021)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 01/01/2023 - "Not long after its introduction, many individuals began to misuse the drug leading to overdoses and drug dependence which brought to light methaqualone's (1) addictive nature. " 04/18/2005 - "In the context of diminishing resources devoted to substance abuse treatment in regions affected by methaqualone abuse, it would be desirable to base treatment on the best evidence available. " 12/01/2021 - "A significant reduction of most CECs was observed at both WWTW locations, except for some that have been previously recorded to persist through various WWTW processes globally, including the illicit drug methaqualone that was reported here for the first time to evaluate its fate during wastewater treatment, substance use trends, and potential toxicological risk. " 07/01/1982 - "For some classes of drugs there has been a noticeable shift in patterns of drug abuse, for example, from abuse of methaqualone to barbiturates. " 08/01/1976 - "After acute ingestion of large quantities of methaqualone (2.4-3.0 g), at least one methaqualone metabolite, [2-methyl-3-(2' hydroxymethylphenyl)-4(3H)-quinazolinone] was present in serum obtained from subjects with a history of chronic drug abuse."
2.	Poisoning 01/01/1968 - "[Contribution to the clinical and chemico-toxicological study of methaqualone poisoning]." 12/01/1995 - "We present a potentially fatal case of acute methaqualone (M) poisoning with very low serum concentrations of M but extremely high levels of its metabolite, 2-methyl-3-(2-hydroxymethyl-phenyl)-4 (3H)-chinazoline (Met-1). " 11/01/1986 - "[Acute methaqualone poisoning]." 10/16/1978 - "[Methaqualone poisoning]." 03/09/1967 - "[Methaqualone (Dormutil) poisoning]."
3.	Hemorrhage 06/01/1978 - "These results suggest that a drug-induced defect of blood platelet function may play a role in the bleeding associated with methaqualone toxicity." 09/01/1982 - " 9 women with no known pathological disorders, aged 21-35 who had been receiving 21 day combined OC therapy for a minimum of 6 months each received a 250 mg oral dose of methaqualone before retiring to bed on day 1 of bleeding and again 14 days later. " 06/01/1978 - "To study the mechanism whereby toxic doses of methaqualone cause a bleeding tendency in humans, the effects of methaqualone, diphenhydramine, and the combination of methaqualone plus diphenhydramine on blood platelet function were investigated. " 02/01/1981 - "A 23-year-old man who had taken an overdose of methaqualone (Quaalude) developed purpura and intraretinal and preretinal (sublaminar) hemorrhages. "
4.	Sleep Initiation and Maintenance Disorders (Insomnia) 04/22/1966 - "Quaalude and insomnia." 01/01/1963 - "Evaluation of 2-methyl-3-orthotolyl-4-(3H)-quinazolinone (methaqualone) in the treatment of insomnia." 02/01/1989 - "374 patients suffering from insomnia were divided into three groups by random: 202 cases in group I were treated with compound Suanzaoren Ansen capsules (SAC); 85 cases in group II were treated with Zhusha Ansen pills (ZAP) as control; 87 cases in group III were treated with Methaqualone (Hyminal) also as control. " 11/01/1966 - "A double-blind comparison of methaqualone, pentobarbital and placebo in the management of insomnia." 01/01/1976 - "The author found flurazepam to be a very efficient hypnotic of relatively low toxicity which could be easily substituted fro barbiturates and methaqualone/diphenhydramine in the treatment of long-term insomnia."
5.	Wounds and Injuries (Trauma) 06/01/2005 - "Efforts to combat the abuse of drugs such as cannabis and methaqualone would appear to be paramount in reducing the burden of injuries on health care services. " 02/04/1983 - "Of 246 methaqualone-related deaths identified during an 11-year period (1971 through 1981), 76% have occurred since 1977 and 72% have involved fatal trauma. " 08/21/1981 - "Methaqualone abuse implicated in injuries, deaths nationwide." 08/01/2002 - "Cannabis and Mandrax (methaqualone), alone or in combination, are the most frequently reported illicit drugs of abuse, generally comprising the largest proportions of drug-related arrests, drug-related psychiatric diagnoses and drug-positive trauma patients. "

Related Drugs and Biologics

1.	Illicit Drugs (Recreational Drugs)
2.	Benzodiazepines
3.	Cocaine (Cocaine HCl)
4.	Opiate Alkaloids
5.	Diphenhydramine (Benadryl)
6.	Mandrax
7.	barbituric acid (barbiturate)
8.	Phencyclidine (Angel Dust)
9.	Amphetamine (Amfetamine)
10.	Dextropropoxyphene (Darvon)

Related Therapies and Procedures

1.	Therapeutics
2.	Hemoperfusion
3.	Peritoneal Dialysis
4.	Hypnosis (Mesmerism)
5.	Renal Dialysis (Hemodialysis)