|1.||Plüddemann, Andreas: 2 articles (06/2005 - 08/2002)|
|2.||Parry, Charles D H: 2 articles (06/2005 - 08/2002)|
|3.||Ceschi, A: 1 article (01/2013)|
|4.||Manini, A F: 1 article (01/2013)|
|5.||Elavumkudy, S: 1 article (01/2013)|
|6.||Giardelli, G: 1 article (01/2013)|
|7.||Müller, D M: 1 article (01/2013)|
|8.||Hofer, K E: 1 article (01/2013)|
|9.||Rauber-Lüthy, C: 1 article (01/2013)|
|10.||Eltahir, Kamal E H: 1 article (01/2012)|
08/01/1986 - "In the patient studied, methaqualone withdrawal was manifested by myoclonic and tonic-clonic seizures, an EEG photoparoxysmal response (PPR), and a high-amplitude visual evoked potential (VEP) to pattern-reversal stimuli. "
08/31/1977 - "Methaqualone produces dose- and time-dependent decreases in susceptibility to electrically, chemically, and sound-induced seizures. "
08/31/1977 - "The effects of methaqualone on the seizure susceptibility of mice."
07/01/1989 - "A dose-dependent increase in the ability of methaqualone to provide protection against pentylenetetrazol (90 mg/kg SC)-induced convulsions in mice was observed. "
01/01/2012 - "A new series of 2,3,8-trisubstituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and Strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate. "
|2.||Substance-Related Disorders (Drug Abuse)
01/01/2005 - "In the context of diminishing resources devoted to substance abuse treatment in regions affected by methaqualone abuse, it would be desirable to base treatment on the best evidence available. "
08/01/1976 - "After acute ingestion of large quantities of methaqualone (2.4-3.0 g), at least one methaqualone metabolite, [2-methyl-3-(2' hydroxymethylphenyl)-4(3H)-quinazolinone] was present in serum obtained from subjects with a history of chronic drug abuse."
07/01/1982 - "For some classes of drugs there has been a noticeable shift in patterns of drug abuse, for example, from abuse of methaqualone to barbiturates. "
01/01/1976 - "Methaqualone (Mandrax) abuse, urine testing, and identification: clinical correlation between a new mass urinalysis test and a military drug abuse program."
01/01/1990 - "Recent studies of drug abuse liability have found that benzodiazepines are minor euphoriants: they are neither sought nor valued on the same level as cocaine, methaqualone, or even alcohol. "
01/01/1968 - "[Contribution to the clinical and chemico-toxicological study of methaqualone poisoning]."
12/01/1995 - "We present a potentially fatal case of acute methaqualone (M) poisoning with very low serum concentrations of M but extremely high levels of its metabolite, 2-methyl-3-(2-hydroxymethyl-phenyl)-4 (3H)-chinazoline (Met-1). "
11/01/1986 - "[Acute methaqualone poisoning]."
10/16/1978 - "[Methaqualone poisoning]."
03/09/1967 - "[Methaqualone (Dormutil) poisoning]."
09/01/1982 - " 9 women with no known pathological disorders, aged 21-35 who had been receiving 21 day combined OC therapy for a minimum of 6 months each received a 250 mg oral dose of methaqualone before retiring to bed on day 1 of bleeding and again 14 days later. "
06/01/1978 - "These results suggest that a drug-induced defect of blood platelet function may play a role in the bleeding associated with methaqualone toxicity."
06/01/1978 - "To study the mechanism whereby toxic doses of methaqualone cause a bleeding tendency in humans, the effects of methaqualone, diphenhydramine, and the combination of methaqualone plus diphenhydramine on blood platelet function were investigated. "
|5.||Wounds and Injuries (Trauma)
06/01/2005 - "Efforts to combat the abuse of drugs such as cannabis and methaqualone would appear to be paramount in reducing the burden of injuries on health care services. "
02/04/1983 - "Of 246 methaqualone-related deaths identified during an 11-year period (1971 through 1981), 76% have occurred since 1977 and 72% have involved fatal trauma. "
08/21/1981 - "Methaqualone abuse implicated in injuries, deaths nationwide."
08/01/2002 - "Cannabis and Mandrax (methaqualone), alone or in combination, are the most frequently reported illicit drugs of abuse, generally comprising the largest proportions of drug-related arrests, drug-related psychiatric diagnoses and drug-positive trauma patients. "
|1.||Serotonin (5 Hydroxytryptamine)
|8.||barbituric acid (barbiturate)
|9.||Phencyclidine (Angel Dust)
|10.||Cocaine (Cocaine HCl)
|2.||Intensive Care (Surgical Intensive Care)
|4.||Renal Dialysis (Hemodialysis)