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Methapyrilene

Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
Also Known As:
Lullamin; N,N-Dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine; Restryl; Tenalin; Thionylan; Thenylpyramine; 1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-
Networked: 53 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Beland, Frederick A: 2 articles (11/2017 - 01/2017)
2. Chen, Tao: 2 articles (11/2017 - 01/2017)
3. Dreval, Kostiantyn: 2 articles (11/2017 - 01/2017)
4. Kindrat, Iryna: 2 articles (11/2017 - 01/2017)
5. Pogribny, Igor P: 2 articles (11/2017 - 01/2017)
6. Shpyleva, Svitlana: 2 articles (11/2017 - 01/2017)
7. de Conti, Aline: 2 articles (11/2017 - 01/2017)
8. Akahori, Yumi: 1 article (10/2019)
9. Ito, Yuko: 1 article (10/2019)
10. Jin, Meilan: 1 article (10/2019)

Related Diseases

1. Necrosis
2. Cholestasis
04/01/2013 - "To gain insights on DILI pathogenesis and identify potential biomarkers for improved DILI detection, we performed untargeted metabolomic analyses on rats treated with thirteen known hepatotoxins causing various types of DILI: necrosis (acetaminophen, bendazac, cyclosporine A, carbon tetrachloride, ethionine), cholestasis (methapyrilene and naphthylisothiocyanate), steatosis (tetracycline and ticlopidine), and idiosyncratic (carbamazepine, chlorzoxasone, flutamide, and nimesulide) at two doses and two time points. "
01/01/2016 - "Visualization of the data with the ABC-derived signature showed a very tight, essentially identically behaving cluster of robust human cholestatic drugs and experimental cholestatic toxicants (ethinyl estradiol, LPS, ANIT and methylene dianiline, disulfiram, naltrexone, methapyrilene, phenacetin, alpha-methyl dopa, flutamide, the NSAIDs--indomethacin, flurbiprofen, diclofenac, flufenamic acid, sulindac, and nimesulide, butylated hydroxytoluene, piperonyl butoxide, and bromobenzene), some slightly less active compounds (3'-acetamidofluorene, amsacrine, hydralazine, tannic acid), some drugs that behaved very differently, and were distinct from both non-cholestatic and cholestatic drugs (ketoconazole, dipyridamole, cyproheptadine and aniline), and many postulated human cholestatic drugs that in rat showed no evidence of cholestasis (chlorpromazine, erythromycin, niacin, captopril, dapsone, rifampicin, glibenclamide, simvastatin, furosemide, tamoxifen, and sulfamethoxazole). "
3. Carcinogenesis
4. Neoplasms (Cancer)
5. Lymphoma (Lymphomas)

Related Drugs and Biologics

1. Flutamide (Eulexin)
2. Carbon Tetrachloride (Tetrachloromethane)
3. Acetaminophen (Paracetamol)
4. nimesulide (Aulin)
5. Cyclosporine (Ciclosporin)
6. Biomarkers (Surrogate Marker)
7. Ticlopidine (Ticlid)
8. Tetracycline (Achromycin)
9. Ethionine
10. Carbamazepine (Tegretol)

Related Therapies and Procedures

1. Oral Administration
2. Aftercare (After-Treatment)