|1.||Tsuneyama, Koichi: 1 article (08/2014)|
|2.||Yamaura, Yu: 1 article (08/2014)|
|3.||Takagi, Shingo: 1 article (08/2014)|
|4.||Nakajima, Miki: 1 article (08/2014)|
|5.||Yokoi, Tsuyoshi: 1 article (08/2014)|
|6.||Tatsumi, Naoyuki: 1 article (08/2014)|
|7.||Fukami, Tatsuki: 1 article (08/2014)|
|8.||Mitsumori, Kunitoshi: 1 article (01/2014)|
|9.||Minami, Keiichi: 1 article (01/2014)|
|10.||Yamada, Hiroshi: 1 article (01/2014)|
09/15/2009 - "Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group. "
09/15/2009 - "Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis."
07/01/2006 - "Male rats were dosed with methapyrilene for 3 days at 150 mg/kg/day, which was sufficient to induce liver necrosis, or a subtoxic dose of 50 mg/kg/day. "
12/15/2000 - "The mechanisms by which acute administration of methapyrilene, an H(1)-receptor antihistamine causes periportal necrosis to rats are unknown. "
09/15/1998 - "Methapyrilene (MP) is an unusual hepatotoxin in that it causes periportal necrosis in rats. "
04/01/2013 - "To gain insights on DILI pathogenesis and identify potential biomarkers for improved DILI detection, we performed untargeted metabolomic analyses on rats treated with thirteen known hepatotoxins causing various types of DILI: necrosis (acetaminophen, bendazac, cyclosporine A, carbon tetrachloride, ethionine), cholestasis (methapyrilene and naphthylisothiocyanate), steatosis (tetracycline and ticlopidine), and idiosyncratic (carbamazepine, chlorzoxasone, flutamide, and nimesulide) at two doses and two time points. "
02/01/1996 - "Previous studies have demonstrated that methapyrilene hydrochloride (MP) is a rat-specific nongenotoxic carcinogen which induces liver tumors in a dose-dependent manner following chronic exposure in the diet. "
11/01/1983 - "The pathogenesis of hepatocellular tumors induced in F344 rats by the antihistaminic methapyrilene was investigated by light and electron microscopy in a serial sacrifice study. "
01/01/1991 - "DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture."
09/01/1986 - "Liver tumors induced in F344 rats by methapyrilene were studied by electron microscopy. "
09/01/1986 - "Ultrastructure of liver tumors induced in F344 rats by methapyrilene."
07/01/1989 - "Rat liver carcinogen methapyrilene (MP) induced mutants of chromosomal origin in the L5178Y/TK+/- ----TK-/- mouse lymphoma."
11/01/1987 - "Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK +/- mouse lymphoma assay."
06/01/1991 - "We studied its ability to form DNA adducts in the L5178Y/TK+/- mouse lymphoma cells, an assay system in which methapyrilene is a moderately active mutagen and appears to induce mutations predominantly of chromosomal origin. "
06/01/1991 - "The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation."
|5.||Liver Neoplasms (Liver Cancer)
01/01/1986 - "These results suggest that none of the four analogs of methapyrilene was carcinogenic under the conditions of this study, and that the property of inducing liver neoplasms in rats was confined to the intact methapyrilene molecule."
01/01/1986 - "The concentrations were 0.1% or 0.05% and the total doses received by the animals were comparable with that of methapyrilene which induced 100% incidence of liver neoplasms. "
03/01/1984 - "The findings suggest that multiple pathways may be followed in the development of methapyrilene-induced liver cancer that are similar to those found in rats exposed to many other hepatic carcinogens."
01/01/1986 - "No increase in incidence of liver neoplasms was observed after treatment with any of the four compounds, thenyldiamine, chlorothen, methafurylene, or methaphenilene, although each differed structurally from methapyrilene only in one atom or one position of substitution. "
|3.||Biological Markers (Surrogate Marker)
|8.||Carbon Tetrachloride (Tetrachloromethane)