|1.||Alzheimer Disease (Alzheimer's Disease)
|3.||Brain Ischemia (Cerebral Ischemia)
|4.||Brain Injuries (Brain Injury)
|1.||Wang, Jian-Zhi: 25 articles (12/2015 - 12/2004)|
|2.||Singh, Nirmal: 19 articles (08/2014 - 07/2007)|
|3.||Kamei, Chiaki: 15 articles (01/2010 - 03/2002)|
|4.||Arancio, Ottavio: 14 articles (01/2015 - 12/2004)|
|5.||Williams, Michael T: 14 articles (07/2013 - 12/2002)|
|6.||Vorhees, Charles V: 14 articles (07/2013 - 12/2002)|
|7.||Tian, Qing: 13 articles (05/2014 - 12/2004)|
|8.||Pitsikas, Nikolaos: 12 articles (01/2015 - 02/2005)|
|9.||Zhu, Ling-Qiang: 11 articles (12/2015 - 06/2006)|
|10.||Zhang, Han-Ting: 11 articles (01/2015 - 08/2004)|
|1.||Amyloid (Amyloid Fibrils)IBA
06/29/2012 - "Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice."
07/01/2011 - "We found that the memory deficit in the AD mice was significantly improved by these treatments, but amyloid β deposition was unchanged. "
04/01/2013 - "The purpose of this study was to investigate the protective effects of L-NNNBP on β-amyloid (Aβ) deposition and memory deficits in an AD model of APP/PS1 mice. "
11/01/2011 - "The aim of this study is to evaluate the protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) on learning and (or) memory deficit in aged rats, as well as to explore the possible connection between TSG and the β-amyloid precursor protein (APP) pathway. "
10/14/2015 - "Using a mouse model of AD, we found that genetic reduction of S6K1 improved synaptic plasticity and spatial memory deficits, and reduced the accumulation of amyloid-β and tau, the two neuropathological hallmarks of AD. "
|2.||Scopolamine (Hyoscine)FDA Link
11/01/2013 - "EUE significantly improved the impairment of short-term or working memory induced by scopolamine in the Y-maze and significantly reversed learning and memory deficits in mice as measured by the passive avoidance and Morris water maze tests. "
01/01/2006 - "DM (40 mg/kg i.p.) was effective in reversing the reference memory deficit induced by administration of scopolamine. "
01/12/2015 - "While orally RA administration (16 and 32 mg/kg) improved learning and memory in control rats, it reversed learning and memory deficits of scopolamine received groups. "
04/10/2014 - "Swimming improved the emotional memory by itself and restored the emotional memory deficit induced by the intra-CA1 injection of scopolamine. "
08/01/2013 - "PEBT improved memory deficits during consolidation and retrieval induced by scopolamine. "
|3.||Dizocilpine Maleate (Dizocilpine)IBA
11/01/2014 - "We found that EE not only has beneficial effects on cognitive performance of normal rats but also prevents spatial learning and memory deficits in Morris water maze induced by MK-801. "
10/01/2008 - "NFPS significantly ameliorated reference memory deficits in a radial maze that occurred following MK801 treatment. "
09/20/2002 - "On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. "
03/01/1999 - "MK-801 improves retention in aged rats: implications for altered neural plasticity in age-related memory deficits."
01/01/1999 - "Following recovery of the spatial memory deficits produced by the brain lesion (four weeks after the brain lesion), dizocilpine (0.1 mg/kg) significantly impaired both reference and working memory, without affecting general behavior or food intake in the brain-lesioned rats. "
|4.||Streptozocin (Streptozotocin)FDA Link
03/01/2011 - "In the present study, IR gene expression was studied by RT-PCR and signaling pathways by immunoblotting in CA1, DG and CA3 subregions of hippocampus in intracerebroventricular (ICV) administered streptozotocin (STZ, 3mg/kg twice) induced memory deficit model in rat. "
01/01/2012 - "Memory deficit was induced by intracerebroventricular administration of streptozotocin (STZ, 3mg/kg) in rats. "
12/01/2003 - "Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats."
04/15/2013 - "Protective effects of oral crocin against intracerebroventricular streptozotocin-induced spatial memory deficit and oxidative stress in rats."
04/01/2007 - "Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice."
|5.||donepezil (Aricept)FDA LinkGeneric
11/27/2015 - "This memory deficit was relieved to some extent either by compound 35 (5 mg/kg) or donepezil (reference compound) treatment (0.75 mg/kg). "
10/01/1999 - "Nineteen patients with memory loss rated improvement while taking 5 mg/day of donepezil (p<.001); subsequently, 6 rated further improvement with 10 mg/day (p = .057). "
06/01/2013 - "We conducted a 3-month, double-blind, placebo-controlled study on the effects of donepezil in 27 older adults with mild memory deficits. "
04/02/2015 - "Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation."
06/01/2013 - "Donepezil alleviated age-related memory deficits, however, by increasing pCREB in the CA1, while pCREB in PL remained unaffected. "
01/01/2010 - "The results indicate that melatonin is effective in providing protection against memory deficit, oxidative stress and neuronal damage induced by STZ."
02/01/2013 - "There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. "
08/01/2005 - "This study indicates that treatment with melatonin prevents learning and memory deficits caused by thinner exposure possibly by reducing oxidative stress and regulating neural plasticity."
11/01/2013 - "Administration of melatonin following SAH significantly ameliorated spatial learning and memory deficits in this prechiasmatic blood injection model. "
01/01/2012 - "Diabetes caused to significant decrease in alternation percent in the cross-arm maze, as a spatial memory index, compared to the control group (p < 0.05), whereas administration of melatonin prevented the spatial memory deficit in diabetic rats. "
|7.||Histamine (Histamine Dihydrochloride)FDA Link
08/01/2009 - "Histamine in the DH ameliorates spatial working memory deficits by acting on histamine H(1) receptors and reference memory deficits through both H(1) and H(2) receptors. "
05/01/2013 - "H₁ but not H₂ histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing."
01/01/2012 - "The present results suggest that the memory deficit induced by early postnatal maternal deprivation in rats may in part be due to an impairment of histamine mediated mechanisms in the CA1 region of the rat hippocampus."
01/01/2012 - "Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation."
01/01/2009 - "Accumulated evidence suggests a role for histamine in cognition and the use of H3 receptor antagonists in the treatment of learning and memory disorders. "
11/01/2014 - "Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways."
10/01/2010 - "These results suggest that Hcy may induce lipid peroxidation in rats' hippocampi and polyphenol treatment (Curcumin) improved learning and memory deficits by protecting the nervous system against Hcy toxicity."
08/01/2013 - "Taken together, the results of the present study suggest that the amelioration of memory deficits by curcumin in aged mice was mediated, at least in part, by activating the nNOS activity in specific brain regions. "
07/01/2011 - "The present study was designed to investigate the role of curcumin in chronic stress and chronic unpredictable stress-induced memory deficits and alteration of functional homeostasis in mice. "
01/01/2013 - "Taken together, these results suggest that curcumin improves the spatial memory disorders (such disorders being symptomatic of AD) in Aβ(1-40)-induced rats by down regulating GFAP expression and suppressing AS activity."
01/01/1991 - "How piracetam exerts its effects on memory disorders is still under investigation, although among other proposed mechanisms of action it is thought to facilitate central nervous system efficiency of cholinergic neurotransmission. "
04/01/1987 - "Adverse side effects were found in only 1 patient (memory loss) which was controlled with administration of piracetam. "
02/28/1977 - "[Nootropyl (piracetam)--memory disorders]."
06/01/2008 - "The ability of piracetam to attenuate memory deficits and neuronal damage after hypoperfusion may be beneficial in cerebrovascular type dementia."
03/01/1989 - "The results indicate that piracetam may be useful in memory deficits induced by malnutrition."
|10.||Levodopa (L Dopa)FDA LinkGeneric
01/01/2008 - "However, L-dopa administration significantly improved PD patients' performance actually restoring the prospective memory deficit. "
06/08/2001 - "These experiments suggest that L-DOPA immediately affected the brain and caused memory deficit. "
08/01/2009 - "Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's disease."
07/01/2008 - "The increased accuracy in complying with the prospective memory task following levodopa medication supports the idea that dopamine depletion plays a role in the prospective memory deficits observed in PD patients."
02/01/2009 - "Consequently, treatment with the dopamine precursor levodopa ameliorates memory deficits in murine models of Alzheimer's disease. "
08/01/2002 - "Oral administration of YZF improved learning and memory disorders induced by chemicals in both normal and senile mice. "
07/01/2015 - "Compound 38b exhibited good selectivity against other PDEs, and oral administration of 38b improved visual-recognition memory deficit in mice at doses of 0.001 and 0.003mg/kg in the novel object recognition test. "
01/01/2014 - "Oral administration of telmisartan at two nonhypotensive doses (0.7 or 0.35 mg/kg) significantly improved memory deficits in STZ-induced diabetic mice. "
03/01/2006 - "Oral administration of withanoside IV (10 micromol/kg/day) significantly improved memory deficits in Abeta(25-35)-injected (25 nmol, i.c.v.) mice and prevented loss of axons, dendrites, and synapses. "
04/21/2015 - "Oral administration of Edaravone also ameliorates the AD-like pathologies and memory deficits of the mice. "
|2.||Transplantation (Transplant Recipients)
04/01/2012 - "The present study demonstrates that brain transplantation of human NSCs over-expressing ChAT ameliorates complex learning and memory deficits in AF64A-cholinotoxin-induced AD rat model."
09/01/2011 - "Intracerebroventricular transplantation of human amniotic epithelial cells ameliorates spatial memory deficit in the doubly transgenic mice coexpressing APPswe and PS1ΔE9-deleted genes."
01/01/2015 - "Morris water maze test in the ovariectomised (OVX) mouse model revealed BMSCs transplantation ameliorated OVX-induced memory deficits by secreted E2. "
09/01/2012 - "Transplantation of GFP cells essentially rescued the cognitive impairment, whereas MyD88-deficient cells significantly accelerated memory deficits of APP(swe)/PS1 mice. "
11/01/2011 - "The results showed that MSC transplantation prevented the development of memory deficit caused by cerebellar degeneration (P≤0.001). "
03/15/2010 - "Neuropsychologic function showed a significant improvement after liver transplant and remained stable in the long term, except for memory loss in those patients with larger increases in white matter lesions. "
04/01/1995 - "Memory deficits produced by the lesions in a spatial win-stay T-maze task (Experiment 1) and a spatial plus associative radial maze task (Experiment 2) were significantly improved by the astrocyte, but not by the neuronal, primary cell transplants. "
01/01/1996 - "In this article, we have reviewed the studies which demonstrate the ability of intrahippocampal septal grafts to reinnervate the hippocampal formation and ameliorate spatial learning and memory deficits. "
08/01/1992 - "In this study, we demonstrate that intrahippocampal grafts of cholinergic-rich striatal tissue also ameliorate spatial memory deficits of rats with fornix lesions. "
05/15/1997 - "The results show that neural transplants can survive within the bird brain and that small lesions of the Hf produce significant spatial memory deficits that can only be reversed by surviving homologous H transplants, and not by heterologous telencephalon transplants."
04/01/2006 - "Procedural sedation and analgesia (PSA) is the safe and effective control of pain, anxiety and motion so as to allow a necessary procedure to be performed and to provide an appropriate degree of memory loss or decreased awareness. "
01/01/2014 - "Acute ethanol administration is associated with sedation and analgesia as well as behavioral disinhibition and memory loss but the mechanisms underlying these effects remain to be elucidated. "
12/01/2014 - "Our findings suggest that postoperative analgesia with ketoprofen can prevent the development of surgery-associated memory deficits via its pain-relieving effects."
06/26/2000 - "20 min earlier, significantly reduced the memory deficit Pretreatment with eptastigmine, a second generation cholinesterase inhibitor, given orally 100 min before the cannabinoid agonist, relieved the memory impairment without affecting CP 55,940-induced behavioural alterations such as reduced spontaneous motor activity, analgesia and hind limb splaying. "
11/01/2012 - "Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia."
|5.||Drug Therapy (Chemotherapy)
09/01/2013 - "Although no pharmacotherapy aimed at counteracting the cognitive and adaptive deficits associated with this genetic disorder has been approved at present, there have been several new promising studies on pharmacological agents capable of rescuing learning/memory deficits seen in mouse models of DS. "
11/01/2012 - "Studies on these modalities have not directly tested the hypothesis of modifying chemotherapy-related cognitive impairment and were done on different disorders of memory loss and lack of concentration. "
01/01/2010 - "As clinical studies reveal that chemotherapeutic agents may impair several different cognitive domains in humans, the development of preclinical animal models is critical to assess the degree of chemotherapy-induced learning and memory deficits and to understand the underlying neural mechanisms. "
01/01/2005 - "This article reviewed related studies on the subject, and found that chemotherapy-induced MCI appears to occur in 10-40% of patients, and memory loss and lack of concentration are the most frequent symptoms. "
03/15/2015 - "Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis."