Melioidosis

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321 relevant articles (28 outcomes, 46 trials/studies) found for this Disease

Description: A disease of humans and animals that resembles GLANDERS. It is caused by BURKHOLDERIA PSEUDOMALLEI and may range from a dormant infection to a condition that causes multiple abscesses, pneumonia, and bacteremia.

Also Known As:

Melioidoses

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses

Bacterial Infections: 6830

Gram-Negative Bacterial Infections: 240

Burkholderia Infections: 4

Melioidosis: 321

Related Diseases

1.	Glanders
2.	Sepsis (Septicemia)
3.	Tularemia
4.	Infection
5.	Plague (Bubonic Plague)

Experts

1.	Peacock, Sharon J: 13 articles (02/2008 - 08/2004)
2.	Cheng, Allen C: 12 articles (02/2008 - 01/2004)
3.	Chierakul, Wirongrong: 12 articles (02/2008 - 03/2003)
4.	Chaowagul, Wipada: 9 articles (02/2008 - 03/2003)
5.	Currie, Bart J: 8 articles (02/2008 - 01/2004)
6.	Limmathurotsakul, Direk: 7 articles (02/2008 - 09/2005)
7.	Wuthiekanun, Vanaporn: 7 articles (08/2007 - 08/2004)
8.	Day, Nicholas P: 6 articles (08/2007 - 10/2005)
9.	White, Nicholas J: 6 articles (08/2007 - 03/2003)
10.	Day, Nicholas P J: 6 articles (08/2007 - 08/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Melioidosis:

1.	Ceftazidime (Fortum)FDA LinkGeneric 09/01/1994 - "Ceftazidime has dramatically improved outcomes in hospitalized patients with severe melioidosis." 05/01/1983 - "Melioidosis was treated successfully with lobectomy and parenteral ceftazidime, which was given for 2 months without major side effects. " 06/01/2004 - "CONCLUSION: This clinical outcome study suggests that out of hospital management of melioidosis with 24 h infusions of ceftazidime via a PICC line is safe and effective." 08/01/2000 - "The aim of this study was to measure the pharmacokinetic and pharmacodynamic effects of continuous infusion of ceftazidime vs intermittent bolus dosing in septicaemic melioidosis. " 05/01/2000 - "The aim of this study was to measure the pharmacokinetic and pharmacodynamic effects of continuous infusion of ceftazidime vs intermittent bolus dosing in septicaemic melioidosis. " Order ALL the reference details at left...
2.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 10/01/2009 - "Prospective PK-PD studies of Asian populations are needed to optimize TMP-SMX dosing in melioidosis." 10/01/2009 - "Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis." 06/01/2005 - "Antimicrobial susceptibility testing using the disc diffusion method is commonly used in melioidosis-endemic areas, but may overestimate resistance to trimethoprim/sulfamethoxazole. " 06/01/2005 - "OBJECTIVES: Trimethoprim/sulfamethoxazole is commonly used to treat melioidosis. " 05/01/2002 - "Cotrimoxazole has been traditionally used for the therapy of melioidosis despite results indicating resistance often produced in the disc diffusion test against B. " Order ALL the reference details at left...
3.	Doxycycline (Vibramycin)FDA LinkGeneric 08/01/1999 - "Doxycycline alone cannot be recommended for a first-line regimen of oral maintenance treatment of melioidosis." 08/01/1999 - "One hundred sixteen patients were enrolled; 109 had culture-confirmed melioidosis, and 87 were considered evaluable (43 had received doxycycline). " 10/01/2005 - "A combination of TMP-SMX and doxycycline is as effective as and better tolerated than the conventional four-drug regimen for the oral treatment phase of melioidosis." 01/01/2009 - "In vitro interactions between cotrimoxazole and doxycycline in Burkholderia pseudomallei: how important is this combination in maintenance therapy of melioidosis?" 01/01/2001 - "Based on our data, a combination of cotrimoxazole and doxycycline treatment for 20 weeks should be given further consideration as the maintenance therapy of choice for melioidosis." Order ALL the reference details at left...
4.	Anti-Bacterial Agents (Antibiotics)IBA 11/01/2009 - "In a region endemic for melioidosis and severe community-acquired Klebsiella pneumoniae, the challenge lies in rapid identification and initiation of appropriate empirical antibiotics to improve the survival of patients with AB CAP." 10/01/2009 - "Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to many antibiotics, resulting in high mortality rates of 19% in Australia and even 50% in Thailand. " 02/01/2009 - "Recurrent cutaneous melioidosis treated with surgery and antibiotics." 12/01/2008 - "Therefore, a heightened awareness of melioidosis among clinicians would have a substantial impact on public health as the non-septicaemic form of the disease is potentially treatable with antibiotics that are available in Cambodian public hospitals." 03/01/2005 - "Some antibiotics used to treat melioidosis can induce filamentation in B. " Order ALL the reference details at left...
5.	DNA (Deoxyribonucleic Acid)IBA 09/01/2000 - "For diagnosis of melioidosis, we compared polymerase chain reaction (PCR)-based DNA detection and three serologic methods with the culture method currently used as gold standard. " 02/05/2000 - "All primer sets were tested by PCR amplification of the same DNA samples extracted from blood specimens of 46 patients from northeastern Thailand, of which 29 had melioidosis based on blood culture as a gold standard. " 09/01/2007 - "We also evaluated these assays with DNA extracted from blood specimens taken from 45 patients with culture-confirmed septicemic melioidosis or other septicemias. " 04/01/2006 - "CONCLUSION: Case-clusters of melioidosis where isolates exhibit diverse DNA macrorestriction patterns in our region are linked to extreme weather events and outbreaks where isolates are predominantly of the same DNA macrorestriction pattern are linked with contamination of an environmental source." 03/01/2006 - "This CpG-modified plasmid DNA vaccination is an important potential strategy that should be developed to protect against melioidosis." Order ALL the reference details at left...
6.	AntigensIBA 01/01/2008 - "The authors did not find that BipB, BipC or BipD are protective antigens because vaccination of mice with any single protein did not result in protection against experimental melioidosis. " 01/01/2003 - "BACKGROUND: This study was undertaken to identify and quantify the class and subclass antibody responses to the culture filtrate antigen (CFA) of Burkholderia pseudomallei in melioidosis patients under long-term maintenance or eradication therapy. " 05/01/1993 - "Results from this study showed that the 19.5-kDa antigen was potentially useful in the diagnosis of melioidosis and deserves further investigation." 05/01/1993 - "In this study five different antigens were prepared and evaluated for their potential usefulness in diagnosis of melioidosis. " 02/01/1990 - "[A study on pathogen antigen and serodiagnosis of Malleus and Melioidosis with McAbs]" Order ALL the reference details at left...
7.	Chloramphenicol (Chloromycetin)FDA Link 11/01/1957 - "Chronic systemic melioidosis; review of literature and report of a case, with a note on visual disturbance due to chloramphenicol." 08/01/1999 - "A prospective, open, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of the conventional four-drug combination (chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline) with that of doxycycline alone in oral maintenance treatment of melioidosis. " 10/01/2005 - "Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis." 08/01/2007 - "All patients with bacteraemic melioidosis died, but treatment with the available conventional therapies of chloramphenicol, co-trimoxazole or doxycycline resulted in survival and cure in six patients with subacute/localised melioidosis. " 08/01/1999 - "A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosis." Order ALL the reference details at left...
8.	Immunoglobulin M (IgM)IBA 01/01/2001 - "The GMTI value of IgM antibody in the sera of melioidosis cases was significantly higher as compared to that of non-melioidosis disease controls (p < or = 0.001). " 06/01/1995 - "The IgM-ELISA was found to be sensitive and useful for the serological diagnosis of acute melioidosis." 06/01/1990 - "The IgM ELISA and IHA should be used in combination for serodiagnosis of melioidosis." 06/01/1990 - "An indirect ELISA for IgM antibody (IgM ELISA) and an IgM antibody capture ELISA for melioidosis were developed. " 06/01/1990 - "Enzyme-linked immunosorbent assay for immunoglobulin M specific antibody for the diagnosis of melioidosis." Order ALL the reference details at left...
9.	Azithromycin (Zithromax)FDA LinkGeneric 02/05/2000 - "pseudomallei which should be used for clinical trials in acute melioidosis are: imipenem, meropenem, and imipenem + azithromycin. " 01/01/2007 - "Moxifloxacin, ertapenem and azithromycin cannot be recommended for the treatment of melioidosis; however, further studies are needed to test the efficacy of azithromycin in combination with quinolones." 01/01/2001 - "Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline." 01/01/2001 - "This is a report of a randomized, open, labeled study of the maintenance treatment of melioidosis using a combination of ciprofloxacin and azithromycin (Regimen A) for 12 weeks versus a combination of cotrimoxazole and doxycycline (Regimen B) for 20 weeks. " Order ALL the reference details at left...
10.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 08/01/2007 - "RESULTS: Over a 27-month period, 60 patients were enrolled to receive either G-CSF (30 patients, 18 of whom had culture-confirmed melioidosis) or placebo (30 patients, 23 of whom had culture-confirmed melioidosis). " 03/01/2004 - "Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis." 07/29/2003 - "G-CSF immunotherapy for treatment of acute disseminated murine melioidosis." 03/01/2004 - "The study reported here was conducted in order to explore the mechanism of action of granulocyte colony-stimulating factor (G-CSF) in the treatment of Burkholderia pseudomallei infections (otherwise known as melioidosis). " 02/01/2008 - "CONCLUSION: G-CSF does not improve outcomes in patients with septic shock, excluding melioidosis. " Order ALL the reference details at left...

Therapies and Procedures

1.	Thrombolytic Therapy 01/01/2009 - "Melioidosis masquerading as community-acquired pneumonia: a case report demonstrating efficacy of intrapleural fibrinolytic therapy." 01/01/2009 - "We report a case of melioidosis originally diagnosed as CAP complicated by empyema successfully cured with combination of antibiotics and intrapleural fibrinolytic therapy, averting operative intervention." Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 06/01/1998 - "Thus many cases of septicemic melioidosis are certain to receive inappropriate chemotherapy and nearly half of them probably leave this world without proper diagnosis in area where under-recognition unfortunately still prevails. " 02/01/1995 - "[Laboratory control of effectiveness of chemotherapy in melioidosis]" 06/01/1998 - "Accordingly, awareness of the disease, familiarity of clinical syndrome compatible with septicemic melioidosis, gram-staining of exudate to include or exclude melioidosis, are all crucial factors to lead to proper empiric chemotherapy. " 04/05/1980 - "Successful treatment of melioidosis relied on prompt laboratory diagnosis and appropriate chemotherapy together with surgical drainage of abscesses and management of concomitant diseases. " 03/01/1948 - "Experimental chemotherapy in glanders and melioidosis." Order ALL the reference details at left...
3.	Intensive Care (Surgical Intensive Care) 11/01/2005 - "STUDY OBJECTIVE: To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. " 11/01/2005 - "CONCLUSIONS: The outcome of severe melioidosis requiring intensive care is poor, with death being predicted by the number of organ dysfunctions." 11/01/2005 - "Clinical characteristics and outcome of severe melioidosis requiring intensive care." Order ALL the reference details at left...
4.	Transplants (Transplant) 03/01/2002 - "Melioidosis presenting as an infected intrathoracic subclavian artery pseudoaneurysm treated with femoral vein interposition graft." 04/01/2006 - "Stent-graft for recurrent melioidosis mycotic aortic aneurysm." 01/01/2005 - "We report the first case of melioidosis infection of a previous femoropopliteal bypass graft complicated by para-anastomotic pseudoaneurysm of the femoral artery successfully treated by surgical removal of the old graft and creation of a new, extraanatomic, external iliac-to-popliteal bypass graft." 01/01/2005 - "Infected pseudoaneurysm of the femoral artery secondary to melioidosis infection of a previous femoropopliteal bypass graft." 04/01/2003 - "We report the case of a patient without contact with the normal sources of infection in whom an iliac mycotic aneurysm was caused by relapsing melioidosis and treated with an extra-anatomic bypass graft." Order ALL the reference details at left...
5.	Debridement 09/01/2008 - "Successful treatment of deep-seated melioidosis can only be achieved when robust antimicrobial therapy is combined with appropriate surgical debridement." 03/01/2008 - "With appropriate antimicrobial treatment and adequate surgical debridement, localized melioidosis can be treated successfully. " Order ALL the reference details at left...

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