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Melibiose

A disaccharide consisting of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.

Also Known As:

D-Glucose, 6-O-alpha-D-galactopyranosyl-

Networked: 22 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - Disaccharides: 990
      - Melibiose: 22
        beta-methylmelibiose
- Sugars: 11126
  - Disaccharides: 990
    - Melibiose: 22
      - beta-methylmelibiose

Experts

1.	Lee-Chen, Guey-Jen: 5 articles (03/2021 - 05/2015)
2.	Lin, Chih-Hsin: 4 articles (01/2020 - 05/2015)
3.	Wu, Yih-Ru: 4 articles (01/2020 - 05/2015)
4.	Lee, Guan-Chiun: 3 articles (03/2021 - 05/2015)
5.	Chen, Chiung-Mei: 3 articles (01/2020 - 05/2015)
6.	Chen, Wan-Ling: 3 articles (01/2020 - 05/2015)
7.	Hsieh-Li, Hsiu Mei: 2 articles (03/2021 - 05/2015)
8.	Chang, Kuo-Hsuan: 2 articles (01/2020 - 01/2020)
9.	Chao, Chih-Ying: 2 articles (01/2020 - 01/2016)
10.	Huang, Yu-Ting: 2 articles (01/2020 - 01/2020)

Related Diseases

1.	Cholestasis 12/01/2008 - "Both, the renal clearance of melibiose and the urinary melibiose/rhamnose ratio remained uninfluenced by cholestasis. " 12/01/2008 - "Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis."
2.	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/01/2016 - "In this study, two trehalase analogs, lactulose and melibiose, were examined for their potentials in spinocerebellar ataxia treatment. " 01/01/2020 - "Its trehalase-indigestible analogs, lactulose and melibiose, also demonstrated potentials to reduce abnormal protein aggregation in spinocerebellar ataxia cell models. " 05/01/2015 - "Using polyQ-mediated spinocerebellar ataxia type 17 (SCA17) cell and slice cultures, we found the aggregation was significantly prohibited by trehalose, lactulose, and melibiose, which may through up-regulating of autophagy. "
3.	Overweight 08/01/2018 - "Composition and metabolism of fecal microbiota from normal and overweight children are differentially affected by melibiose, raffinose and raffinose-derived fructans." 08/01/2018 - "The main conclusion from the study is that fecal microbiota of normal and overweight children have different compositions and they respond in specific manners to non-digestible oligo- and polysaccharides: raffinose, melibiose, raffinose-derived oligosaccharides and levans. "
4.	Extrahepatic Cholestasis 12/01/2008 - "The altered melibiose/rhamnose biliary excretion ratio in BDO rats indicates that the test is able to detect the impairment of the blood-biliary barrier in acute extrahepatic cholestasis." 12/01/2008 - "The objective of the present study was therefore two-fold: First, to describe in detail the biliary pharmacokinetics of melibiose and rhamnose in rats; second, to evaluate the changes of both sugars' pharmacokinetics upon impairment of the blood-biliary barrier by acute extrahepatic cholestasis in rats. "
5.	Ischemic Stroke 09/10/2021 - "Our data suggests that melibiose-augmented neuroprotection may be achieved by ameliorating autophagy flux via facilitation of TFEB nuclear translocation in neurons after ischemic stroke." 09/10/2021 - "The present study was to investigate whether melibiose could also confer a neuroprotection by the similar pharmacological mechanism as trehalose did after ischemic stroke. "

Related Drugs and Biologics

1.	Rhamnose
2.	Lactulose (Duphalac)
3.	Sugars
4.	Trehalose
5.	Trehalase
6.	Oligosaccharides
7.	Raffinose
8.	Polysaccharides (Glycans)
9.	Fructans (Levans)
10.	Lactose