|2.||Primitive Neuroectodermal Tumors (PNET)
|3.||Brain Neoplasms (Brain Tumor)
|4.||Astrocytoma (Pilocytic Astrocytoma)
|5.||Neoplasm Metastasis (Metastasis)
|1.||Taylor, Michael D: 63 articles (11/2015 - 09/2003)|
|2.||Northcott, Paul A: 38 articles (06/2015 - 04/2009)|
|3.||Kool, Marcel: 37 articles (05/2015 - 02/2006)|
|4.||Gajjar, Amar: 37 articles (03/2015 - 08/2002)|
|5.||Rutkowski, Stefan: 36 articles (11/2015 - 03/2005)|
|6.||Eberhart, Charles G: 34 articles (03/2014 - 08/2002)|
|7.||Korshunov, Andrey: 32 articles (02/2015 - 05/2004)|
|8.||Remke, Marc: 30 articles (11/2015 - 04/2009)|
|9.||Pfister, Stefan M: 30 articles (06/2015 - 10/2010)|
|10.||Clifford, Steven C: 27 articles (11/2015 - 10/2002)|
|1.||Vincristine (Oncovin)FDA LinkGeneric
01/01/2015 - "Weekly, an intravenous bolus of vincristine was combined for patients with SR medulloblastoma and patients participating in the COG-ACNS-0332 study. "
09/01/2011 - "Concurrent radiochemotherapy for medulloblastoma includes the microtubule disrupting agent vincristine; however, vincristine alone or as part of a combined treatment regimen is highly toxic. "
11/01/2009 - "Dose reductions of vincristine in children with medulloblastoma treated in the maintenance arm of the prospective multicenter trial HIT'91."
01/01/2007 - "These in vitro findings indicate a favourable interaction of IR and HDIs, but an unfavourable one of IR and vincristine, in medulloblastoma, and provide a rationale for comparing the combination of IR with either vincristine or HDIs in vivo."
06/01/2006 - "High risk medulloblastoma patients with postoperative gross residual disease that was >1.5 cm2 and/or metastatic disease (M+) were planned to receive craniospinal irradiation (CSI) 36 Gy followed by boost to the posterior fossa for a total of 55.8 Gy. Concomitantly during radiation, patients received weekly vincristine 1.5 mg/m2. "
|2.||Cisplatin (Platino)FDA LinkGeneric
10/01/2014 - "In this study, we show that SPARC expression induces cisplatin resistance in medulloblastoma cells. "
01/01/2014 - "CCD is not associated with EFS or OS suggesting that lower doses of cisplatin may be incorporated into future medulloblastoma trials, thereby limiting its toxicity profile without affecting survival. "
01/01/2014 - "The purpose of this study was to evaluate the survival outcomes based on cumulative cisplatin doses (CCD) in children with newly diagnosed average-risk medulloblastoma. "
02/01/2000 - "To elucidate this possibility for medulloblastoma cells, 10 microM/l RA, 1.0 microg/ml cisplatin (CP) and their half-dosage combinations were utilized in this study to treat Med-3 cells and their influences in cell proliferation, morphology and death patterns were evaluated. "
11/01/2015 - "Therefore, we examined SOD2 variants in association with ototoxicity among cisplatin-treated childhood medulloblastoma patients. "
|3.||Etoposide (VP 16)FDA LinkGeneric
07/01/2009 - "In this study, human medulloblastoma (DAOY) cells were exposed to the common chemotherapeutic agent etoposide, and Raman spectra from patterned cells were recorded over 48 hours. "
01/01/2014 - "The ability to distinguish between effects on malignant and the proliferating component of normal brain was tested using etoposide on UW228-3 medulloblastoma cell line and human neural stem cells. "
01/01/2010 - "p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma."
02/01/2008 - "Under basal growth conditions and in response to the chemotherapeutic agent, etoposide, WIP1 antagonized p53-mediated apoptosis in medulloblastoma cell lines. "
10/01/1998 - "High-dose (5g/m2/24 h) MTX therapy was combined with two etoposide (100mg/m2/ 1 h) infusions as a part of the medulloblastoma protocol developed in our department. "
|4.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/15/2009 - "This method has been used to measure plasma cyclophosphamide and CEPM concentrations in an ongoing Phase II study in children with newly diagnosed medulloblastoma."
01/01/2002 - "Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines."
05/01/2008 - "The total expression profiles of two medulloblastoma cell lines resistant to the preactivated form of cyclophosphamide (4-hydroperoxycyclophosphamide, 4-HC) were examined using the Affymetrix GeneChip U133A array. "
05/01/2008 - "The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide."
01/01/1995 - "Medulloblastoma, the most common malignancy of childhood, was originally shown to be sensitive to cyclophosphamide in 1981. "
|5.||Methotrexate (Mexate)FDA LinkGeneric
11/01/2015 - "To assess feasibility, acute toxicity, and efficacy of intraventricular methotrexate administered as part of the primary therapy in medulloblastoma. "
07/01/2009 - "For this study, 17 patients (6 medulloblastoma, 5 ALL treated with high-dose methotrexate (MTX) (4 x 5 g/m(2)) and 6 with low-dose MTX (3 x 2 g/m(2))) and 17 age-matched controls participated. "
12/15/2004 - "With the majority of patients with disseminated medulloblastoma having M2 or M3 disease at diagnosis, the encouraging high response rate of this intensified induction regimen suggests that such an addition of methotrexate should be explored in future studies."
11/01/2015 - "Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: Feasibility, acute toxicity and evidence for efficacy."
05/01/2012 - "In conclusion, despite a very high response rate with this preradiation HD methotrexate schedule, the outcome for high-risk medulloblastoma patients did not improve (especially when lower CSI doses were used) and patients still developed severe morbidities."
|6.||Lomustine (CCNU)FDA Link
01/01/2013 - "Lomustine is a nitrosourea anticancer agent shown to be effective for treatment of childhood medulloblastoma. "
06/01/1999 - "In addition, lipid-associated CCNU exhibited a 4-fold increase in drug sensitivity with medulloblastoma cells. "
06/01/1999 - "Lipid association increases the potency against primary medulloblastoma cells and systemic exposure of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in rats."
01/01/1978 - "In assessable patients with pur medulloblastoma, three out of three showed marked responses to CCNU. "
03/30/1974 - "Letter: CCNU in teatment of recurrent medulloblastoma."
|7.||Procarbazine (Matulane)FDA Link
03/01/1982 - "When the combination treatment of the human medulloblastoma xenograft with procarbazine was used, the ILS was significantly increased in all four experiments, ranging from 25 to 41%, and was superior to single-modality treatment in all but the 1050-rad treatment, where it showed an equal effect. "
09/01/2001 - "The xenografts evaluated were derived from a childhood glioblastoma multiforme (D-456 MG), a childhood medulloblastoma (D-341 MED), an adult anaplastic astrocytoma (D-54 MG), an adult glioblastoma multiforme (D-245 MG), and a procarbazine-resistant subline of D-245 MG [D-245 MG (PR)]. "
01/01/1998 - "Tumors included adult high-grade gliomas (D-54 MG, D-245 MG), childhood high-grade gliomas (D-212 MG, D-456 MG), medulloblastomas (D-341 MED, D-487 MED), ependymomas (D-612 EP, D-528 EP), and a mismatch repair-deficient procarbazine-resistant glioma [D-245 MG (PR)]. "
01/01/1992 - "The drug combination vincristine, procarbazine, and dibromdulcitol proved to be effective in a pilot trial on relapsed medulloblastomas: 8 complete and 4 partial remissions were achieved from 16 cases. "
03/01/1988 - "Forty-seven patients with medulloblastoma were treated postoperatively with procarbazine, followed by craniospinal radiation therapy in combination with hydroxyurea. "
|8.||Carboplatin (JM8)FDA LinkGeneric
03/01/2011 - "Twenty-four medulloblastoma patients were treated according to HIT protocols with carboplatin substitution between April 1999 and June 2006. "
07/20/2012 - "Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study."
10/01/1995 - "Preoperative chemotherapy with carboplatin alone in high risk medulloblastoma."
03/01/1995 - "Carboplatin in childhood medulloblastoma/PNET: feasibility of an in vivo sensitivity test in an "up-front" study."
07/20/2012 - "We evaluated the feasibility of administering carboplatin as a radiosensitizer during craniospinal radiation therapy (CSRT) to patients with high-risk medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumors, and we report the outcome in the subset with metastatic (M+) MB. "
|9.||DNA (Deoxyribonucleic Acid)IBA
01/01/2003 - "The present study indicates that the loss of function of DNA double-strand break-sensing and repair molecules is an etiological factor in the evolution of the cerebellar medulloblastomas. "
07/01/2000 - "In this study, we directly sequenced the PTCH gene in 20 sporadic medulloblastoma DNA samples. "
07/01/1999 - "In this study, comparative genomic hybridization, which allows the detection of losses and gains in DNA copy number along the entire genome, was used to investigate the genetic alterations in 6 cases of medulloblastoma with adequate follow-up periods and similar treatments, and in a medulloblastoma cell line. "
10/01/2015 - "Common genetic variants (single nucleotide polymorphisms) annotating these genes (n = 221) were genotyped in germline DNA (neonatal dried blood spot samples) from 243 childhood medulloblastoma cases and 247 control subjects from Sweden and Denmark. "
12/01/2014 - "Its expression in human medulloblastoma shifts that perspective, suggesting that CUX1 is part of a network involved in cell cycle control and maintenance of DNA integrity. "
05/15/2010 - "Our study thus demonstrated for the first time that trans-resveratrol is the bioactive form in medulloblastoma cells in which the expression of brain-associated SULTs was down-regulated, resulting in the increased intracellular bioavailability and anti-medulloblastoma efficacy of trans-resveratrol."
08/01/2011 - "Therefore, appropriate inhibition of NF-κB activation may enhance the anti-medulloblastoma efficacy of resveratrol."
11/01/2006 - "The correlation of c-Myc expression with resveratrol-induced turnover of medulloblastoma cells was investigated in this study by checking (1) c-Myc expression in medulloblastoma tissues and cell lines (UW228-2 and UW228-3), (2) the in vitro effect of resveratrol on c-Myc expression and (3) the influences of c-Myc inhibition in cell growth and survival. "
11/13/2003 - "In this study, resveratrol was used to treat four human medulloblastoma cell lines (Med-3, UW228-1, -2 and -3) and its effects on cell growth, differentiation and death were examined by multiple approaches. "
07/01/2012 - "Our data from human medulloblastoma cells and primary cultures of rat brain cells revealed an inverse correlation of sulfonation activity with resveratrol sensitivities, providing a clue to the underlying mechanisms of the variable sensitivities of GBM cells to resveratrol. "
|1.||Drug Therapy (Chemotherapy)
12/15/2010 - "The data of 31 patients in continuous complete remission after removal of medulloblastoma, irradiation and chemotherapy, were retrospectively reviewed. "
04/01/2010 - "Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy."
01/01/1994 - "We report full details of this case in which active treatments consisting mainly of chemotherapy proved to be effective for recurrent medulloblastoma, even though its prognosis is generally very unfavorable."
12/01/2006 - "Pre-irradiation chemotherapy is effective in high risk medulloblastoma and is associated with acceptable side effects. "
01/15/2000 - "Maintenance chemotherapy would seem to be more effective in low-risk medulloblastoma, especially in patients older than 6 years of age. "
01/01/1986 - "A medulloblastoma in a 7-year-old girl showed complete remission after the initial radiotherapy of 5,000 rad. "
04/01/2002 - "In adult medulloblastoma, postoperative radiotherapy is significantly effective in prolonging time to recurrence and survival time; however, the response of individual cases to radiotherapy, that is the total survival, is different. "
09/01/1993 - "Approximately 45-50% of children with medulloblastoma are cured by conventional surgery and radiotherapy, but survivors may face severe late neuropsychological toxicity. "
04/01/1985 - "Improved radiotherapy techniques have changed the near fatal prognosis for children with medulloblastoma to a 50%, 5-year survival. "
10/01/2011 - "In the present study, we demonstrate that Gadd45a expression can sensitize medulloblastoma cells to radiotherapy. "
|3.||Heterologous Transplantation (Xenotransplantation)
04/01/2012 - "We previously demonstrated the efficacy of a recombinant oncolytic measles virus (MV) to treat localized medulloblastoma in a mouse xenograft model. "
09/15/2007 - "Intratumoral injection of live myxoma virus when compared with control inactivated virus prolonged survival in D341 and Daoy orthotopic human medulloblastoma xenograft mouse models [D341 median survival: 21 versus 12.5 days; P = 0.0008; Daoy median survival: not reached (three of five mice apparently "cured" after 223 days) versus 75 days; P = 0.0021]. "
07/01/2010 - "Previous studies have shown that GSI treatment caused apoptosis and impaired medulloblastoma cell engraftment in xenograft systems. "
02/01/2008 - "In the present study, we observed strong morphological similarities between medulloblastoma xenografts overexpressing HGF and medulloblastoma xenografts overexpressing c-Myc. "
03/01/2004 - "The purpose of this study was to evaluate the effect of basic fibroblastic growth factor (bFGF) on the growth of human UM-MB1 medulloblastoma xenografts injected intracranially in nude mice. "
10/01/2007 - "As expected, incorporation of adjuvant chemotherapy in the treatment of Greek children with medulloblastoma has yielded remarkable improvement in 5-year survival, comparable to that of technologically advanced countries. "
03/01/1991 - "Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma."
10/01/1988 - "Efficacy of adjuvant chemotherapy for patients with poor-risk medulloblastoma: a preliminary report."
09/01/2006 - "Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma."
06/01/2006 - "In the present study, we examined the potential roles of cellular differentiation, proliferation and apoptosis in 21 pediatric patients with newly diagnosed classic medulloblastomas treated by conventional radiation therapy and adjuvant chemotherapy. "
|5.||Combination Drug Therapy (Combination Chemotherapy)
04/15/1983 - "Thirty-six patients with recurrent medulloblastoma were treated with various combination chemotherapy protocols after initial treatment (usually irradiation) failed. "
07/01/1982 - "The principle of giving intensive polychemotherapy in the time between operation and irradiation was applied in a cooperative phase-2-study in children with medulloblastoma of the posterior fossa. "
01/01/1979 - "Combination chemotherapy in recurrent medulloblastoma."
09/01/2004 - "She did not respond to a therapeutic regimen specific for promyelocytic leukemia but achieved complete remission of the medulloblastoma as well as the leukemia after the administration of polychemotherapy specific for medulloblastoma. "
02/01/2012 - "Medulloblastoma, the most common pediatric malignant brain tumor, is an example of a disease that has benefitted from advances in diagnostic imaging, surgical techniques, radiation therapy and combination chemotherapy over the past decades. "