Medroxyprogesterone

A synthetic progestational hormone used in veterinary practice as an estrus regulator.

Also Known As:

17 alpha-Hydroxy-6 alpha-Methylprogesterone; Adgyn Medro; 17 alpha Hydroxy 6 alpha Methylprogesterone; (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione; Methylhydroxyprogesterone; Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6alpha)-

Networked: 335 relevant articles (25 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnenes: 1
        Pregnenediones
        Progesterone: 12723
        Hydroxyprogesterones
        Medroxyprogesterone: 335
        Medroxyprogesterone Acetate: 2154
        divina: 3
        ACM protocol
        klimaxil
        medroxyprogesterone-17-hemisuccinate
        VAC-MAP protocol

Experts

1.	Altinoz, Meric A: 3 articles (01/2019 - 05/2007)
2.	Demers, Christine: 3 articles (02/2018 - 07/2005)
3.	Derzko, Christine: 3 articles (02/2018 - 07/2005)
4.	Douglas, Joanne: 3 articles (02/2018 - 07/2005)
5.	Herold, Betsy C: 3 articles (01/2014 - 12/2005)
6.	Polo, Olli: 3 articles (04/2005 - 02/2004)
7.	Saaresranta, Tarja: 3 articles (04/2005 - 02/2004)
8.	Maguire, Melissa J: 2 articles (01/2021 - 10/2019)
9.	Nevitt, Sarah J: 2 articles (01/2021 - 10/2019)
10.	Curtis, Kathryn M: 2 articles (04/2019 - 02/2006)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 04/04/2005 - "Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease." 10/01/2004 - "Trials are reviewed evaluating ventilatory parameters with acetazolamide and/or medroxyprogesterone in patients with COPD. " 11/01/2002 - "Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients." 10/01/2004 - "Significant improvement in arterial blood gas and ventilatory parameters was reported in COPD patients after acetazolamide and medroxyprogesterone treatment; however, with no improvement in survival or quality of life, the place of these drugs in therapy remains unknown." 08/01/1986 - "Previous studies have shown that some patients with chronic obstructive lung disease and hypercapnia will respond to medroxyprogesterone with improvement in arterial blood gases. "
2.	Neoplasms (Cancer) 09/01/2005 - "Characterization of medroxyprogesterone and DMBA-induced multilineage mammary tumors by gene expression profiling." 01/01/1992 - "In the first approach medroxyprogesterone dosage increased up to 400 mg a day, achieved better results in curative as well as adjuvant treatment of advanced or early gynecologic cancers. " 08/01/1986 - "In this selected group of patients, oral medroxyprogesterone at a dose level of 400 mg/day appeared to provide a significant frequency of tumor response." 02/01/1981 - "Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone." 10/02/1976 - " In December 1974, a tumor was discovered and treated with medroxyprogesterone 250 mg/day. "
3.	Endometriosis 01/01/2013 - "Treatment with Medroxyprogesterone was 100% effective in terms of relapse, while Triptorelinum could not prevent recurrence of endometriosis." 07/01/2000 - "Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study." 12/01/1961 - " The 19-norsteroids and medroxyprogesterone are being used in the treatment of endometriosis. " 04/01/2007 - "We collected the samples of endometrium from patients with endometriosis before operation or after insertion of levenorgestrel releasing intrauterine system (LNG-IUS), administration of oral medroxyprogesterone (MPA), or injection of gonadotrophic hormone releasing hormone agonist (GnRHa). " 04/01/2007 - "To investigate the apoptosis-related mechanisms of levenorgestrel-releasing intrauterine system (LNG-IUS), oral medroxyprogesterone (MPA), and injective gonadotrophic hormone releasing hormone agonist (GnRHa) on eutopic endometrium of patients with endometriosis. "
4.	Amenorrhea 12/01/1997 - "Uncomplicated amenorrhea in PCOS is managed with monthly or bimonthly administration of medroxyprogesterone. " 06/01/1994 - "Cyclic medroxyprogesterone increased spinal bone density in physically active women experiencing amenorrhea or ovulatory disturbances. " 04/15/1964 - "PROLONGED AMENORRHEA FOLLOWING MEDROXYPROGESTERONE." 10/01/1999 - "[Evaluation of safety in Chinese women with amenorrhea following injection of depot-medroxyprogesterone for contraception]." 05/01/1995 - "The role of orally administered medroxyprogesterone at a dose of 10 mg per day, 10 days per month, in improving BMD in teenage girls with hypothalamic amenorrhea or oligomenorrhea remains to be established. "
5.	Respiratory Insufficiency (Respiratory Failure) 02/01/2004 - "This case documents successful control of chronic respiratory failure with medroxyprogesterone in a postmenopausal woman during 1-year follow-up." 02/01/2004 - "Medroxyprogesterone improves cardiac autonomic control in postmenopausal women with respiratory insufficiency." 08/01/2000 - "Prolonged endocrine responses to medroxyprogesterone in postmenopausal women with respiratory insufficiency." 09/01/2002 - "This case documents the treatment of chronic type II respiratory failure secondary to central hypoventilation with medroxyprogesterone, a new treatment option." 07/01/1999 - "Two of these patients appeared to stabilise with no appreciable change clinically or in lung function on medroxyprogesterone and/or tamoxifen, but the remaining patients all deteriorated with two dying of respiratory insufficiency and one of infection following lung transplantation. "

Related Drugs and Biologics

1.	Gases
2.	Conjugated (USP) Estrogens (Premarin)
3.	Medroxyprogesterone Acetate (Depo-Provera)
4.	Levonorgestrel (Plan B)
5.	Acetazolamide (Diamox)
6.	Gonadotropin-Releasing Hormone (GnRH)
7.	Megestrol
8.	Oral Contraceptives
9.	Steroids
10.	Minerals

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Intrauterine Devices (Intrauterine Device)
4.	Endometrial Ablation Techniques
5.	Artificial Respiration (Mechanical Ventilation)