Medigoxin (Metildigoxin)

A semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action. Its cardiotonic action is prolonged by its demethylation to DIGOXIN in the liver. It has been used in the treatment of congestive heart failure (HEART FAILURE).

Also Known As:

Metildigoxin; 4'''-O-Methyldigoxin; Bemecor; Lanirapid; Lanitop; Medixin; Methyldigoxin; 4''' O Methyldigoxin; beta Methyldigoxin; beta-Methyldigoxin; Card-20(22)-enolide, 3-((O-2,6-dideoxy-4-O-methyl-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-

Networked: 54 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Harada, Jun: 1 article (01/2018)
2.	Morita, Maki: 1 article (01/2018)
3.	Sano, Fumiaki: 1 article (01/2018)
4.	Sato Boku, Aiji: 1 article (01/2018)
5.	Shibuya, Yasuyuki: 1 article (01/2018)
6.	So, MinHye: 1 article (01/2018)
7.	Sobue, Kazuya: 1 article (01/2018)
8.	Tamura, Tetsuya: 1 article (01/2018)
9.	Fox, P R: 1 article (03/2016)
10.	Vollmar, A C: 1 article (03/2016)

Related Diseases

1.	Heart Failure 03/01/1991 - "The efficacy of beta methyldigoxin was examined in a group of 40 elderly patients who had been hospitalised due to congested heart decompensation. " 03/01/1991 - "In this paper, a course of the disease of a 68-year-old patient treated with medigoxin for congestive heart failure is presented. " 01/01/1983 - "Relationship between myocardial uptake and actions in heart failure of methyldigoxin." 09/01/1975 - "Multiclinical open studies on the effect of beta-methyldigoxin on congestive heart failure with atrial fibrillation." 01/01/1989 - "23 horses and one donkey with congestive heart failure are treated with a standardized methyldigoxin dose (0.0032 mg/kg of body weight). "
2.	Pleural Effusion (Pleural Effusions) 11/01/1997 - "A chest radiograph revealed cardiomegaly, small bilateral pleural effusions, and hilar congestion--findings that improved after early therapy with furosemide and methyldigoxin. "
3.	Cardiomegaly (Heart Hypertrophy) 11/01/1997 - "A chest radiograph revealed cardiomegaly, small bilateral pleural effusions, and hilar congestion--findings that improved after early therapy with furosemide and methyldigoxin. "
4.	Fibrosis (Cirrhosis) 03/01/1984 - "According to our findings there is more danger of digitalis toxicity in patients with cirrhosis of the liver on a standard dosage of metildigoxin than on a standard dosage of beta-acetyldigoxin." 03/01/1984 - "In patients with cirrhosis the proportion of serum beta-methyldigoxin averaged 77.7% of the total digoxin concentration, whereas the proportion was only 37.5% in healthy volunteers. " 03/01/1984 - "The digoxin levels in patients with cirrhosis treated with metildigoxin were statistically significantly higher than in healthy volunteers. " 03/01/1984 - "Changes in metildigoxin pharmacokinetics in cirrhosis of the liver: a comparison with beta-acetyldigoxin." 10/02/1981 - "There is greater danger of digitalis toxicity in patients with cirrhosis of the liver on standard dosage of beta-methyldigoxin than on standard dosage of beta-acetyldigoxin."
5.	Atrial Fibrillation 09/01/1975 - "Multiclinical open studies on the effect of beta-methyldigoxin on congestive heart failure with atrial fibrillation." 04/01/1997 - "The patient had received metildigoxin 0.2 mg.day-1 for atrial fibrillation preoperatively and severe bradycardia of 35-41 bpm was found on the preoperative ECG examination. " 09/01/1975 - "The average maintenance does of beta-methyldigoxin in 102 cases of congestive heart failure with atrial fibrillation was 0.177 mg per day. " 10/01/1980 - "A comparison of digoxin and medigoxin in treating atrial fibrillation." 07/01/1979 - "Comparison of medigoxin and digoxin in the control of atrial fibrillation."

Related Drugs and Biologics

1.	Furosemide (Lasix)
2.	Medigoxin (Metildigoxin)
3.	Acetyldigoxins
4.	Digoxin (Digitek)
5.	Verapamil (Calan)
6.	Tablets
7.	Glycosides
8.	Digitoxin
9.	Spironolactone (Aldactone)
10.	Propranolol (Inderal)

Related Therapies and Procedures

1.	Secondary Prevention
2.	Therapeutics
3.	Intravenous Administration
4.	Renal Dialysis (Hemodialysis)
5.	Extracorporeal Circulation