|2.||Wounds and Injuries (Trauma)
|1.||Ingemansson, Richard: 16 articles (01/2014 - 04/2004)|
|2.||Malmsjö, Malin: 16 articles (01/2013 - 12/2004)|
|3.||Sjögren, Johan: 9 articles (10/2007 - 04/2004)|
|4.||Gustafsson, Ronny: 7 articles (12/2006 - 04/2004)|
|5.||Kyo, Shunei: 6 articles (06/2011 - 09/2002)|
|6.||Trouillet, Jean-Louis: 5 articles (02/2015 - 03/2004)|
|7.||Hetzer, Roland: 5 articles (11/2010 - 06/2004)|
|8.||Petzina, Rainer: 5 articles (11/2010 - 07/2006)|
|9.||Song, David H: 4 articles (12/2015 - 06/2006)|
|10.||Kawata, Mitsuhiro: 4 articles (03/2015 - 07/2010)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
12/01/2007 - "Prompt recognition, adequate operative drainage, and appropriate antibiotics remain the best treatment for descending necrotizing mediastinitis."
04/01/2008 - "Despite the increased use of CT scan as a diagnostic aid and the improvement in antibiotics, mortality in patients with descending necrotising mediastinitis remains high, reported between 25 and 40% in the literature. "
11/01/2013 - "In addition, because the patient responded well to antibiotics, a diagnosis of acute mediastinitis was reached. "
08/01/2011 - "After a diagnosis of acute mediastinitis was confirmed we gave him antibiotics, which improved his symptoms, the mediastinal fatty area and his WBC and CRP levels. "
06/01/2003 - "With the prevention of mediastinitis using antibiotics, all patients recovered. "
01/01/2008 - "[The use of the vancomycin paste for sternal hemostasis and mediastinitis prophylaxis]."
11/01/2003 - "Successful treatment of vancomycin resistant Enterococcus faecium mediastinitis associated with left ventricular assist devices."
01/01/2000 - "Is the use of topical vancomycin to prevent mediastinitis after cardiac surgery justified?"
12/01/1997 - "[Postoperative mediastinitis due to methicillin resistant Staphylococcus epidermidis with low sensitivity to vancomycin]."
02/01/1995 - "[Intermittent mini-dose vancomycin intravenous administration and closed continuous irrigation technique applied to mediastinitis caused by MRSA following mitral valve replacement]."
|3.||linezolid (Zyvox)FDA Link
07/01/2008 - "Efficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental study."
03/01/2009 - "Our study showed that linezolid appears to be a promising option for treating mediastinitis due to methicillin-resistant S. "
01/01/2015 - "Treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose."
01/01/2015 - "This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. "
03/01/2009 - "We aimed to investigate the therapeutic efficacy of linezolid in an experimental mediastinitis model and to compare it with vancomycin, which is commonly used. "
06/01/2004 - "Efficacy of continuous cleansing with teicoplanin on post-CABG methicillin-resistant staphylococcus aureus (MRSA) mediastinitis: report of a case."
06/01/2006 - "Combined therapy of teicoplanin and caffeic acid phenethyl ester (CAPE) in the treatment of experimental mediastinitis in the rat."
02/01/2003 - "We clinically evaluated the efficacy of the combination therapy of teicoplanin (TEIC) with cefmetazole (CMZ) in two patients, one (case 1) had developed surgical site infection and the other (case 2) mediastinitis caused by methicillin-resistant Staphylococcus aureus (MRSA) after cardiovascular surgeries. "
07/01/2009 - "Linezolid and teicoplanin therapy was found as effective as standard vancomycin therapy for methicillin resistant Staphylococcus aureus (MRSA) mediastinitis. "
07/01/2009 - "The purpose of our study was to research the role of hyperbaric oxygen therapy (HBO) in the treatment of experimental mediastinitis and to investigate whether it potentiates the antibiotic effects of linezolid, teicoplanin, and vancomycin. "
|5.||Povidone-Iodine (Betadine)FDA LinkGeneric
03/01/2003 - "The authors were consulted on a 45-year-old patient with mediastinitis who had renal and hepatic dysfunction while being treated with mediastinal irrigation of povidone-iodine. "
03/01/2003 - "Continuous mediastinal irrigation with povidone-iodine is used commonly for treating severe postoperative mediastinitis. "
01/01/1997 - "To avoid the problems seen with the use of povidone-iodine solution, we applied electrolyzed strong acid aqueous solution (ESAAS) to mediastinal irrigation in 4 patients (2 infants and 2 adults) who developed mediastinitis after cardiovascular surgery. "
01/01/1997 - "Dilute povidone-iodine solution has been widely used as an irrigant for the treatment of mediastinitis. "
12/01/1993 - "MRSA mediastinitis was successfully treated by continuous closed irrigation with 0.5% povidone-iodine solution. "
02/01/1990 - "In conclusion, 1) mediastinal isolation with primary skin closure seemed more effective for preventing mediastinitis than coverage with prosthetic materials, 2) DSC was possible when there were hemodynamic improvements with decrease in CVP and LAP levels, and reduction in catecholamine dosage, and 3) plastic surgical technique was useful for primary skin closure."
01/01/1991 - "The mediastinal irrigation is the treatment of choice for benign mediastinitis, but the prognosis of severe mediastinitis was in our series greatly improved by muscle flap procedures realized with plastic and reconstructive surgical techniques."
01/01/2012 - "Between September 2009 and June 2011, 6 patients were referred to the Department of Plastic and Reconstructive Surgery and the Department of Thoracic and Cardiovascular Surgery of Ajou University Hospital for poststernotomy mediastinitis. "
01/01/2011 - "The treatment options varied from the prolonged antibiotic therapy to plastic reconstructive surgery, which were determined by the severity of mediastinitis."
01/01/2006 - "[Early one-stage plastic repair of tracheal lesions in the treatment of flegmon of the neck and acute contact mediastinitis]."
|7.||tigecycline (Tygacil)FDA Link
12/01/2012 - "The use of the nitinol clip favored an improved sternal closure technique preventing mediastinitis. "
05/01/2009 - "VAC is a safe and effective option in the treatment of post-sternotomy mediastinitis, with excellent survival and immediate improvement of local wound conditions; furthermore, the use of Nitinol clips after VAC therapy demonstrated to be a safe and non-invasive option for sternal resynthesis. "
01/01/1999 - "CLINICAL PHASE: Phase III. Placebo-controlled investigation of the clinical efficacy of Pentaglobin (Biotest, Germany) as an added treatment in patients with mediastinitis. "
01/01/1999 - "Adjuvant treatment of mediastinitis with immunoglobins (Pentaglobin) after cardiac surgery (ATMI): study protocol."
01/01/1999 - "Sternal wound infections and mediastinitis after cardiac surgery are to be investigated in the ATMI study with Pentaglobin. "
01/01/1999 - "Consensus-assisted protocol development and discussion forum of a study protocol on adjuvant treatment of mediastinitis with immunoglobulins (pentaglobulin) after cardiac surgery (ATMI)."
01/01/1999 - "Microbiology and antibiotic treatment--discussion forum on a study protocol on adjuvant treatment of mediastinitis with immunoglobulins (Pentaglobin) after cardiac surgery (ATMI)."
05/01/2010 - "In all studies examining hospital stay, duration was reduced in cases where cyanoacrylate glue was used, both in patients treated for recurrent mediastinitis (24.06 vs. 14.16 days) and those with uncomplicated recovery following cardiac surgery (13 vs. 9 days). "
08/01/2012 - "This single-centre investigation used two prospective registries to evaluate the prophylactic effect of a cyanoacrylate-based antimicrobial skin sealant (InteguSeal®) on the incidence of postoperative mediastinitis or any other form of chest skin incision SSI after elective cardiac surgery. "
10/01/2002 - "Eighteen cases of mediastinitis were treated with the same method added sternal cyanoacrylate gluing (Group II). "
10/01/2002 - "Sternal cyanoacrylate gluing in mediastinitis. "
10/01/2002 - "Cyanoacrylate is effective in diminishing sternal wound complications and related cost and hospital stay of mediastinitis."
10/01/2014 - "In conclusion, the haemodynamics of children were not significantly affected by the negative pressure of VAC, indicating that this therapy may be safe and effective for post-sternotomy mediastinitis, even in small children with complex cardiac anomalies."
03/01/2004 - "The interlocking sternotomy significantly reduced the incidence of sternal instability and helped to prevent sternal dehiscence and mediastinitis. "
06/01/2006 - "The combination of an antioxidant / anti-inflammatory agent, CAPE, added to standard antibiotic therapy might be effective in the treatment of post-sternotomy mediastinitis due to MRSA."
12/01/2015 - "Rigid sternal fixation in the management of pediatric postmedian sternotomy mediastinitis: A 20-year study."
10/01/2014 - "This study aimed to evaluate outcomes and effects of VAC on the haemodynamics of paediatric patients with post-sternotomy mediastinitis. "
|2.||Negative-Pressure Wound Therapy
12/01/2008 - "Negative pressure wound therapy (NPWT) has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome. "
10/01/2007 - ": Vacuum-assisted closure has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome achieved with its use. "
09/01/2010 - "Combination of continuous irrigation and vacuum-assisted closure is effective for mediastinitis after cardiac surgery in small children."
04/01/2006 - "Numerous authors have reported promising results with the use of vacuum-assisted closure therapy in poststernotomy mediastinitis. "
12/01/2004 - "Several authors have reported promising results with vacuum-assisted closure therapy in poststernotomy mediastinitis. "
08/01/1998 - "Radical debridement and omental transposition may achieve a cure for postoperative mediastinitis with good mid-term results."
01/01/2012 - "The efficacy of immediate debridement and reconstruction with a pectoralis major muscle flap designed for the defect immediately after the diagnosis of poststernotomy mediastinitis is demonstrated. "
10/01/1993 - "We conclude that early debridement and omental flap transposition are effective in the management of mediastinitis after cardiac surgery."
11/01/2009 - "The results of our studies demonstrate that vacuum therapy in conjunction with early and aggressive debridement is an effective strategy for treating poststernotomy mediastinitis. "
10/01/2002 - "Clinical study: in 17 cases of mediastinitis, debridement and rewiring the sternum, was applied as the treatment method (Group I). "
07/01/2005 - "Omental flap transposition can be effective for treating mediastinitis following prosthetic graft replacement of the ascending aorta. "
08/01/2001 - "Prompt conservative surgical treatment including omental transposition can be effective in the treatment of mediastinitis following graft replacement of the ascending aorta."
12/01/2014 - "For this reason, we aimed to study the effect of mediastinitis on graft patency after CABG. "
08/01/2007 - "Few studies have focussed on patients' experiences of and suffering due to mediastinitis following Coronary Artery by-pass Graft (CABG). "
05/01/2005 - "But, till now, no study has been done to detect the effects of mediastinitis to graft patency. "
03/01/2014 - "Using stents in therapy neither increased survival (mortality of 25%), nor decreased the length of therapy of patients once mediastinitis had developed. "
03/01/2014 - "To evaluate the use of esophageal stents for the treatment of patients suffering from mediastinitis. "
03/01/2014 - "Esophageal stents for less invasive treatment of mediastinitis."
01/01/2014 - "Mediastinitis by Actinomyces meyeri after oesophageal stent placement."
01/01/2011 - "Use of endoscopic nasobiliary drainage tube for treating mediastinitis caused by insertion of an esophageal self-expanding metal stent."