Meconium Aspiration Syndrome

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294 relevant articles (22 outcomes, 28 trials/studies) found for this Disease

Description: A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.

Also Known As:

Aspiration, Meconium; Meconium Aspiration; Aspiration Syndrome, Meconium; Syndrome, Meconium Aspiration

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 372

Lung Diseases: 8778

Meconium Aspiration Syndrome: 294

Respiration Disorders: 11

Meconium Aspiration Syndrome: 294

Female Urogenital Diseases and Pregnancy Complications

Pregnancy Complications: 515

Fetal Diseases: 562

Meconium Aspiration Syndrome: 294

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Fetal Diseases: 562

Meconium Aspiration Syndrome: 294

Diseases Newborn Infant

Meconium Aspiration Syndrome: 294

Related Diseases

1.	Pulmonary Hypertension (Ayerza Syndrome)
2.	Diaphragmatic Hernia
3.	Respiratory Insufficiency (Respiratory Failure)
4.	Sepsis (Septicemia)
5.	Syndrome
63 Diseases and 162 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Kääpä, P: 3 articles (01/2005 - 02/2001)
2.	Du, Li-zhong: 3 articles (01/2005 - 08/2003)
3.	Calkovska, Andrea: 2 articles (08/2008 - 10/2004)
4.	Javorka, Kamil: 2 articles (08/2008 - 10/2004)
5.	Drgova, Anna: 2 articles (08/2008 - 10/2004)
6.	Kleinsasser, Axel: 2 articles (02/2008 - 01/2006)
7.	Loeckinger, Alexander: 2 articles (02/2008 - 01/2006)
8.	Geiger, Ralf: 2 articles (02/2008 - 01/2006)
9.	Pajk, Werner: 2 articles (02/2008 - 01/2006)
10.	Neu, Nikolaus: 2 articles (02/2008 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Meconium Aspiration Syndrome:

1.	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/01/2000 - "CONCLUSION: In this model of meconium aspiration syndrome, short-term exposure to inhaled nitric oxide when combined with high-frequency oscillatory ventilation improved oxygenation secondary to better distribution of inhaled nitric oxide" 10/01/1999 - "To investigate the possible protective effects of nitric oxide (NO) inhalation in newborns with meconium aspiration, 18 10-12-d-old piglets were studied for 6h after an intratracheal bolus (3 ml/kg) of a 65-mg/ml mixture of human meconium" 02/01/2007 - "Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets." 10/01/2000 - "OBJECTIVE: To test the hypothesis that inhaled nitric oxide, when combined with high-frequency oscillatory ventilation, is an effective therapeutic agent in meconium aspiration syndrome" 10/01/2000 - "Effect of nitric oxide and high-frequency oscillatory ventilation in meconium aspiration syndrome." Get all the results and reference details, order at left...
2.	Hydrocortisone (Cortisol)FDA LinkGeneric 03/01/1975 - "Because of this decreased survival and the relatively insignificant improvement in clinical course and histopathology found with glucocorticoid treatment, we cannot recommend cortisol for the treatment of meconium aspiration." 01/01/1977 - "Hydrocortisone therapy in meconium aspiration syndrome: a controlled study." 01/01/1977 - "To evaluate the efficacy of glucocorticoids in the treatment of infants with meconium aspiration syndrome, a double-blind study using hydrocortisone or a lactose placebo was undertaken" Get all the results and reference details, order at left...
3.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2004 - "AIM: To compare three different schedules in severe meconium aspiration syndrome (MAS) treatment: standard, bronchoalveolar lavage (BAL) with diluted surfactant, and diluted surfactant BAL plus a single early dexamethasone dose" 02/01/2001 - "These results show that prophylactic dexamethasone treatment significantly attenuates the early pulmonary hemodynamic deterioration and structural lung damage caused by meconium aspiration" 02/01/2001 - "Dexamethasone treatment attenuates pulmonary injury in piglet meconium aspiration." 08/01/1999 - "We examined the effects of dexamethasone on lung function in a piglet model of meconium aspiration syndrome" 08/01/1999 - "Effects of dexamethasone on meconium aspiration syndrome in newborn piglets." Get all the results and reference details, order at left...
4.	GlucocorticoidsIBA 03/01/1975 - "An animal model of meconium aspiration was developed to determine the efficacy of glucocorticoids in its treatment" 11/01/2008 - "Glucocorticoids may improve lung function in newborns with meconium aspiration syndrome (MAS), but information on the acute side effects of glucocorticoids in infants is limited" 01/01/1977 - "To evaluate the efficacy of glucocorticoids in the treatment of infants with meconium aspiration syndrome, a double-blind study using hydrocortisone or a lactose placebo was undertaken" Get all the results and reference details, order at left...
5.	OxygenIBA 06/01/2006 - "OBJECTIVE: This study examined the changes of regional cerebral oxygen saturation (rSO2) by noninvasive near infrared spectrophotometry in neonates with meconium aspiration syndrome (MAS)" 06/01/2006 - "Regional cerebral oxygen saturation in neonates with meconium aspiration syndrome]" 09/01/2001 - "Newborn piglets with meconium aspiration resuscitated with room air or 100% oxygen." 10/01/2000 - "Arterial saturation and partial pressure of arterial oxygen (Pao2) were significantly lower after meconium aspiration when compared with baseline" 10/01/1997 - "Arterial oxygen saturation and Pao2 were significantly lower after meconium aspiration when compared with baseline values" Get all the results and reference details, order at left...
6.	GasesIBA 09/01/1982 - "Serial measurements of pulmonary function and arterial blood gases during the first 3 postnatal days of life were obtained in 12 infants with meconium aspiration syndrome (MAS)" 09/01/1982 - "Lung volume, dynamic lung compliance, and blood gases during the first 3 days of postnatal life in infants with meconium aspiration syndrome." 12/01/2000 - "NIMV reversed deliberately induced hypoventilation and normalized the changes in arterial blood gases induced by meconium aspiration" 10/01/2001 - "Despite the good response (blood gases and cardiovascular profile) to partial liquid ventilation in meconium aspiration syndrome, pulmonary hypertension did not decrease" 04/01/2006 - "The association between occiput posterior position and neonatal outcomes, including 5-minute Apgar scores, umbilical cord gases, meconium-stained amniotic fluid, meconium aspiration syndrome, birth trauma, admission to the intensive care nursery, and length of stay were examined using chi(2) and Student t tests" Get all the results and reference details, order at left...
7.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2005 - "There are limited data on the efficacy of antibiotics in the management for meconium aspiration syndrome (MAS)" 06/01/2007 - "BACKGROUND: Meconium aspiration syndrome (MAS) is a major cause of severe respiratory distress in newborns and the role of antibiotics in its management is not well defined" 06/01/2007 - "Role of antibiotics in meconium aspiration syndrome." 05/01/1995 - "It is concluded that empirical use of antibiotics in the routine management of meconium aspiration syndrome is of no benefit." 05/01/1995 - "A randomized clinical trial was conducted to evaluate the utility of antibiotics in the routine management of Meconium Aspiration Syndrome (MAS)" Get all the results and reference details, order at left...
8.	poractant alfa (Curosurf)FDA Link 02/01/1999 - "Subgroups of animals were treated with Curosurf (80 mg/ml, dose 200 mg/kg) 30 min after meconium aspiration; no additional material was instilled in controls" 01/01/1993 - "Both groups responded to treatment with exogenous surfactant (Curosurf, 200 mg/kg) with a moderate, statistically significant improvement in lung-thorax compliance, PCO2 and alveolar VV. Our data indicate that respiratory failure after neonatal meconium aspiration may be influenced favorably by treatment with exogenous surfactant." 03/01/2006 - "Biophysical and antibacterial properties of Curosurf and PxB may be combined into a useful adjunct in the treatment of neonatal Gram-negative pneumonia and/or meconium aspiration syndrome." 08/01/2008 - "The enrichment of Curosurf with dextran improves meconium clearance and lung functions in surfactant-lavaged rabbits with meconium aspiration." Get all the results and reference details, order at left...
9.	Superoxide DismutaseIBA 10/01/2004 - "OBJECTIVE: To evaluate the protective effects of recombinant human superoxide dismutase (rhSOD) in acute lung injury (ALI) following meconium aspiration" 10/01/2004 - "Protective effects and mechanisms of recombinant human superoxide dismutase in acute lung injury of rats following meconium aspiration]" 01/01/2005 - "OBJECTIVE: To investigate the anti-inflammation and anti-oxidation effects of recombinant human CuZn superoxide dismutase(rhSOD) on acute lung injury (ALI) induced by meconium aspiration in rats" 01/01/2005 - "Anti-inflammation and anti-oxidation effects of recombinant human superoxide dismutase on acute lung injury induced by meconium aspiration in infant rats]" Get all the results and reference details, order at left...
10.	tezosentanIBA 01/01/2006 - "Tezosentan decreases pulmonary artery pressure and improves survival rate in an animal model of meconium aspiration." 01/01/2006 - "Tezosentan improved survival and decreased pulmonary artery pressure in a porcine model of acute pulmonary arterial hypertension after meconium aspiration" 02/01/2008 - "Intravenous tezosentan improves gas exchange and hemodynamics in acute lung injury secondary to meconium aspiration." 01/01/2006 - "We tested whether intravenous tezosentan, a dual endothelin receptor antagonist, reduced pulmonary artery pressure in a pig model of acute lung injury induced by meconium aspiration" 02/01/2008 - "We investigated the intrapulmonary and hemodynamic effects of the intravenous dual endothelin A and B receptor blocker tezosentan and inhalational iloprost in a model of ALI due to meconium aspiration" Get all the results and reference details, order at left...
123 Drugs and Important Bio-Agents and 155 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Extracorporeal Membrane Oxygenation (ECMO) 05/01/2003 - "In trials in severe meconium aspiration syndrome, surfactant therapy reduced the need for extracorporeal membrane oxygenation" 01/01/2003 - "This questionnaire study was designed to determine how consultant paediatricians perceived the value of extracorporeal membrane oxygenation (ECMO) in the treatment of meconium aspiration syndrome (MAS)" 07/01/2007 - "We compared the morbidity of patients with meconium aspiration syndrome (MAS) with that in patients with all other respiratory conditions treated with extracorporeal membrane oxygenation (ECMO) (no MAS)" 07/01/2007 - "ECMO for meconium aspiration syndrome: support for relaxed entry criteria." 03/12/2007 - "ECMO is primarily used in infants with severe meconium aspiration, but can be used for all kinds of pulmonary and cardiac failures as well" Get all the results and reference details, order at left...
2.	High-Frequency Jet Ventilation 01/01/2003 - "AIM: To determine the efficacy of the expulsion effect of high-frequency jet ventilation (HFJV) on meconium clearance from the airways in comparison with conventional suctioning in adult rabbits with meconium aspiration" 10/01/1994 - "In vitro data have shown a concentration-dependent inhibition of surfactant by meconium, while anecdotal reports demonstrate improved oxygenation after surfactant replacement in babies with meconium aspiration syndrome, particularly in conjunction with high-frequency jet ventilation" 01/01/2005 - "Surfactant lung lavage using asymmetric high-frequency jet ventilation followed by conventional ventilation in rabbits with meconium aspiration." 10/01/2004 - "Treatment of experimental meconium aspiration syndrome with surfactant lung lavage and conventional vs. asymmetric high-frequency jet ventilation." 01/01/2003 - "Lung lavage using high-frequency jet ventilation in rabbits with meconium aspiration." Get all the results and reference details, order at left...
3.	High-Frequency Ventilation 07/01/2007 - "Physiological effects of lavage were documented, and comparison was made with a group of infants with meconium aspiration requiring high-frequency ventilation, in whom lavage was not performed" 07/01/2007 - "METHODS: Infants with severe meconium aspiration requiring high-frequency ventilation underwent lung lavage using dilute bovine surfactant at a phospholipid concentration of 5 mg/mL. Lavage aliquot volumes were increased through the case series, aiming to deliver two aliquots of 15 mL/kg in rapid sequence" 02/01/1999 - "Combined effects of high-frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome." 11/01/1992 - "OBJECTIVE--To assess the usefulness of three methods of high-frequency ventilation in the early management of a piglet model of the meconium aspiration syndrome" 08/01/1986 - "High frequency positive pressure ventilation in experimental meconium aspiration syndrome." Get all the results and reference details, order at left...
4.	Aftercare (After-Treatment) 09/01/1996 - "We studied ventilation efficiency after treatment with a modified porcine surfactant in experimental meconium aspiration" 06/01/1992 - "OBJECTIVE: To determine whether abnormalities in lung mechanics detected in infants during the acute phase of meconium aspiration syndrome persist after treatment with extracorporeal membrane oxygenation (EMCO)" 10/01/1997 - "CONCLUSIONS: In this model of meconium aspiration syndrome, short-term exposure to inhaled nitric oxide after treatment with surfactant improved oxygenation secondary to better distribution of inhaled nitric oxide" 10/01/1997 - "Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant." Get all the results and reference details, order at left...
5.	Liquid Ventilation 03/01/2000 - "A randomised control study of partial liquid ventilation after airway lavage with exogenous surfactant in a meconium aspiration syndrome animal model." 10/01/2001 - "CONCLUSIONS: Partial liquid ventilation with perfluorocarbon could be a good noninvasive alternative technique that improves gas exchange and pulmonary mechanics in meconium aspiration syndrome without impairing cardiovascular function." 10/01/2001 - "Partial liquid ventilation in term newborn lambs with experimental meconium aspiration did not alter cardiovascular profile: heart rate, systemic arterial pressure, and cardiac output maintained initial values throughout the experiment" 10/01/2001 - "The cardiovascular effects of partial liquid ventilation in newborn lambs after experimental meconium aspiration." 04/01/2001 - "Spontaneous breathing during partial liquid ventilation in animals with meconium aspiration." Get all the results and reference details, order at left...
28 Therapies and Procedures and 174 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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